5-hydroxycamphor | 22285-79-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5-hydroxycamphor
• 英文别名: 5-hydroxy-bornan-2-one；5-Hydroxy-bornan-2-on；5-hydroxy-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
• CAS: 22285-79-6
• 化学式: C₁₀H₁₆O₂
• 分子量: 168.236
• InChiKey: DJQYBVLXBVJHMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-hydroxycamphor 、 水 、 alkaline earth salt of/the/ methylsulfuric acid 生成 樟脑 、 2,5-bornanediol
  参考文献：
  名称：

  Ishidate, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1928, vol. 48, p. 77

  摘要：

  DOI：
• 作为产物：
  描述：

  樟脑 生成 5-hydroxycamphor
  参考文献：
  名称：

  Ishidate, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1928, vol. 48, p. 77

  摘要：

  DOI：

文献信息

• [EN] KETOCAMPHOLENIC ACID DERIVATIVES AND THEIR USE IN FRAGRANCE APPLICATIONS<br/>[FR] DERIVES D'ACIDE CETOCAMPHOLENIQUE ET LEUR UTILISATION DANS DES APPLICATIONS DE FRAGRANCE
  申请人：AROMAGEN CORP

  公开号：WO2004013079A1

  公开（公告）日：2004-02-12

  Ketocampholenic acid derivatives, their use, and methods of preparing these derivatives are described. In one aspect, novel derivatives of 2-oxo-4,5,5-trimethylcyclopent-3-enylacetic acid (herein further referred as ketocampholenic acid or KCA), which is a natural product that may be prepared by microbial biological oxidation of camphor or of a suitable precursor, are described. Novel derivative compounds may be prepared according to the methods described in the present invention. Such derivative olfactory properties that make them useful in fragrance and flavor applications.

  描述了Ketocampholenic酸衍生物、它们的用途以及制备这些衍生物的方法。在一个方面，描述了2-氧代-4,5,5-三甲基环戊-3-烯基乙酸（以下简称为Ketocampholenic酸或KCA）的新衍生物，这是一种天然产物，可以通过对藿香脑或适当前体进行微生物生物氧化来制备。根据本发明描述的方法可以制备新的衍生物化合物。这些衍生物具有使它们在香味和风味应用中有用的嗅觉特性。
• Method of Isolating P450 Gene
  申请人：Kubota Mitsutoshi

  公开号：US20080220419A1

  公开（公告）日：2008-09-11

  The present invention provides a method for preparing a hybrid gene. The method includes a step of amplifying a P450 gene fragment contained in a sample using primers designed on the basis of regions of a plurality of P450 in which amino acid sequences are highly conserved and a step of preparing the hybrid gene using the amplified fragments and a known P450 gene. The method includes no culturing step or a step of normalizing extracted DNAs and is useful in isolating a P450 gene from various microbial resources. The present invention further provides a fused cytochrome P450 monooxygenase containing a peptide which is linked to the C-terminus of a P450 protein with a linker portion disposed therebetween and which has the same function as that of a reductase domain contained in a cytochrome P450 monooxygenase originating from Rhodococcus sp. strain NCIMB 9784. This enables the construction of a high-efficiency electron transfer system useful for various P450 proteins and also enables the production of an active P450 monooxygenase.

  本发明提供了一种制备杂交基因的方法。该方法包括放大样本中包含的P450基因片段的步骤，使用基于多个P450区域高度保守的氨基酸序列设计的引物，并使用放大的片段和已知的P450基因制备杂交基因。该方法不包括培养步骤或提取DNA的归一化步骤，并且有助于从各种微生物资源中分离P450基因。本发明还提供了一种融合的细胞色素P450单加氧酶，其包含一个肽链，该肽链连接到P450蛋白的C-末端，并在两者之间具有连接器部分，具有与Rhodococcussp.菌株NCIMB 9784来源的细胞色素P450单加氧酶中包含的还原酶域相同的功能。这使得构建高效的电子转移系统对于各种P450蛋白非常有用，并且还能够生产活性P450单加氧酶。
• METHOD OF ISOLATING P450 GENE
  申请人：MARINE BIOTECHNOLOGY INSTITUTE CO., LTD.

  公开号：EP1811029A1

  公开（公告）日：2007-07-25

  The present invention provides a method for preparing a hybrid gene. The method includes a step of amplifying a P450 gene fragment contained in a sample using primers designed on the basis of regions of a plurality of P450 in which amino acid sequences are highly conserved and a step of preparing the hybrid gene using the amplified fragments and a known P450 gene. The method includes no culturing step or a step of normalizing extracted DNAs and is useful in isolating a P450 gene from various microbial resources. The present invention further provides a fused cytochrome P450 monooxygenase containing a peptide which is linked to the C-terminus of a P450 protein with a linker portion disposed therebetween and which has the same function as that of a reductase domain contained in a cytochrome P450 monooxygenase originating from Rhodococcus sp. strain NCIMB 9784. This enables the construction of a high-efficiency electron transfer system useful for various P450 proteins and also enables the production of an active P450 monooxygenase.

  本发明提供了一种制备杂交基因的方法。该方法包括使用根据多种 P450 的氨基酸序列高度保守的区域设计的引物扩增样品中所含的 P450 基因片段的步骤，以及使用扩增片段和已知 P450 基因制备杂交基因的步骤。该方法不包括培养步骤或将提取的 DNA 归一化的步骤，可用于从各种微生物资源中分离 P450 基因。 本发明进一步提供了一种融合的细胞色素 P450 单加氧酶，该融合的细胞色素 P450 单加氧酶含有一个多肽，该多肽与 P450 蛋白的 C 端相连，中间有一个连接部分，其功能与源自 Rhodococcus sp.这样，就能构建一个对各种 P450 蛋白有用的高效电子传递系统，还能生产一种活性 P450 单加氧酶。
• Method of isolating P450 Gene
  申请人：KNC Laboratories Co., Ltd

  公开号：EP2017334A2

  公开（公告）日：2009-01-21

  The present invention provides a method for preparing a hybrid gene. The method includes a step of amplifying a P450 gene fragment contained in a sample using primers designed on the basis of regions of a plurality of P450 in which amino acid sequences are highly conserved and a step of preparing the hybrid gene using the amplified fragments and a known P450 gene. The method includes no culturing step or a step of normalizing extracted DNAs and is useful in isolating a P450 gene from various microbial resources. The present invention further provides a fused cytochrome P450 monooxygenase containing a peptide which is linked to the C-terminus of a P450 protein with a linker portion disposed therebetween and which has the same function as that of a reductase domain contained in a cytochrome P450 monooxygenase originating from Rhodococcus sp. strain NCIMB 9784. This enables the construction of a high-efficiency electron transfer system useful for various P450 proteins and also enables the production of an active P450 monooxygenase.

  本发明提供了一种制备杂交基因的方法。该方法包括使用根据多种 P450 的氨基酸序列高度保守的区域设计的引物扩增样品中所含的 P450 基因片段的步骤，以及使用扩增片段和已知 P450 基因制备杂交基因的步骤。该方法不包括培养步骤或将提取的 DNA 归一化的步骤，可用于从各种微生物资源中分离 P450 基因。 本发明进一步提供了一种融合的细胞色素 P450 单加氧酶，该融合的细胞色素 P450 单加氧酶含有一个多肽，该多肽与 P450 蛋白的 C 端相连，中间有一个连接部分，其功能与源自 Rhodococcus sp.这样，就能构建一个对各种 P450 蛋白有用的高效电子传递系统，还能生产一种活性 P450 单加氧酶。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。