1,3-bis(hexadecyloxy)propan-2-ylamine | 70077-72-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,3-bis(hexadecyloxy)propan-2-ylamine
• 英文别名: 1,3-di(n-hexadecyloxy)-2-aminopropane；1,3-bis(hexadecyloxy)propan-2-amine；1,3-dihexadecyloxy-2-aminopropane；1,3-dihexadecoxypropan-2-amine
• CAS: 70077-72-4
• 化学式: C₃₅H₇₃NO₂
• 分子量: 539.97
• InChiKey: FXPQEQPJRBVGRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.6
• 重原子数：
  38
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,3-bis(hexadecyloxy)propan-2-ylamine 在 sodium hydroxide 、 四丁基氢氧化铵 、 氨 、 氢气 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 N'-(1,3-dihexadecoxypropan-2-yl)propane-1,3-diamine
  参考文献：
  名称：

  DE2835369

  摘要：

  公开号：
• 作为产物：
  描述：

  tert-butyl 1,3-bis(hexadecyloxy)propan-2-ylcarbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 1,3-bis(hexadecyloxy)propan-2-ylamine
  参考文献：
  名称：

  [EN] CATIONIC LIPIDS AND USES THEREOF
  [FR] LIPIDES CATIONIQUES ET UTILISATIONS DE CEUX-CI

  摘要：

  阳离子脂质、基于阳离子脂质的药物传递系统、制备它们的方法以及利用它们治疗疾病的方法被披露。

  公开号：

  WO2009129385A1

文献信息

• Stabilization of nucleic acid amplification cocktails
  申请人：Applied Gene Technologies, Inc.

  公开号：US06379930B1

  公开（公告）日：2002-04-30

  The present invention provides a cocktail of reagents for nucleic acid amplification that are stabilized by inclusion of a reversible inhibitor of undesirable reactions. Such cocktail of reagents eliminates the requirement for separate preparation and quality control of each reagent used in a reaction. Methods to prepare stabilized cocktails and to use stabilized cocktails also are included. The stabilized cocktail compositions also can include reagents to release nucleic acid from cells and to label the nucleic acid, allowing detection of nucleic acid in a sample with a single reagent addition step. The invention also provides kits for performing the above methods.

  本发明提供了一种核酸扩增试剂混合物，通过包含可逆抑制剂来稳定不良反应。这种试剂混合物消除了反应中每种试剂单独制备和质量控制的要求。本发明还包括制备稳定的混合物和使用稳定的混合物的方法。稳定的混合物组合物还可以包括释放细胞中的核酸和标记核酸的试剂，使得用单一试剂添加步骤检测样品中的核酸成为可能。本发明还提供执行上述方法的试剂盒。
• Antiviral amine derivatives of glycerol and propanediols
  申请人：Pfizer Inc.

  公开号：US04166132A1

  公开（公告）日：1979-08-28

  Novel amine and amidine derivatives of di-0-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-0-(n-hexadecyl)-2-0-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts.

  新型的二0-(n-高级脂肪烷基和烯基)-甘油和-丙二醇的胺和酰胺衍生物，及其药学上可接受的酸盐，可用于治疗哺乳动物的病毒感染。特别感兴趣的是1,3-二0-(n-十六烷基)-2-0-(3-氨基丙基)-甘油及其药学上可接受的酸盐。
• Sample processing to release nucleic acids for direct detection
  申请人：——

  公开号：US20010031473A1

  公开（公告）日：2001-10-18

  The present invention describes compositions and methods for releasing nucleic acids from cells in a form that is suitable for labeling/capture, amplification, or detection in a single reagent addition step. The compositions include a lipid, membrane fluidizing compound, enzyme for degrading cell structure, metal chelators, or one or more nucleic acid probes or primers complementary to the nucleic acid to be detected. The compositions are non-denaturing and non-inhibitory of enzymes or proteins that are used in nucleic acid release, amplification, labeling or detection. The invention also provides kits for performing the above methods.

  本发明描述了一种将核酸从细胞中释放出来并以适合于标记/捕获、扩增或检测的形式的组合物和方法，该方法只需要一次试剂添加步骤。该组合物包括脂质、膜流动化合物、降解细胞结构的酶、金属螯合剂或与待检测的核酸互补的一个或多个核酸探针或引物。该组合物是非变性的，不会抑制用于核酸释放、扩增、标记或检测的酶或蛋白质。本发明还提供了用于执行上述方法的试剂盒。
• Antiviral amine derivatives of propanediols
  申请人：Pfizer Inc.

  公开号：US04193999A1

  公开（公告）日：1980-03-18

  Novel amine and amidine derivatives of di-O-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-O-(n-hexadecyl)-2-O-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts.

  Novel amine and amidine derivatives of di-O-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-O-(n-hexadecyl)-2-O-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts. 翻译成中文： 新型的二元醇和丙二醇的氨基和酰胺衍生物，以及它们的药用酸盐，对于治疗哺乳动物的病毒感染非常有用。特别是1,3-二-O-(n-十六烷基)-2-O-(3-氨丙基)-甘油和它的药用酸盐。
• Antiviral amine and amidine derivatives of glycerol and propanediols
  申请人：Pfizer Inc.

  公开号：US04262021A1

  公开（公告）日：1981-04-14

  Novel amine and amidine derivatives of di-O-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-O-(n-hexadecyl)-2-O-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts.

  Novel amine and amidine derivatives of di-O-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-O-(n-hexadecyl)-2-O-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts. 翻译：新型的二-O-(n-较高烷基和烯基)-甘油和丙二醇的胺和酰胺衍生物及其药学上可接受的酸盐，对于治疗哺乳动物的病毒感染具有有用的作用。特别感兴趣的是1,3-二-O-(n-十六烷基)-2-O-(3-氨丙基)-甘油及其药学上可接受的酸盐。