2-(2-ethoxy-1-(3-methylbut-1-en-2-yloxy)but-3-enyl)cyclopropane | 934668-08-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-ethoxy-1-(3-methylbut-1-en-2-yloxy)but-3-enyl)cyclopropane
• 英文别名: [2-Ethoxy-1-(3-methylbut-1-en-2-yloxy)but-3-enyl]cyclopropane
• CAS: 934668-08-3
• 化学式: C₁₄H₂₄O₂
• 分子量: 224.343
• InChiKey: MKFQZKODYDHIJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-ethoxy-1-(3-methylbut-1-en-2-yloxy)but-3-enyl)cyclopropane 在 Hoveyda-Grubbs catalyst second generation 三氟乙酸 作用下， 以 甲苯 为溶剂， 以60%的产率得到2-cyclopropyl-5-isoppropylfuran
  参考文献：
  名称：

  A Metathesis-Based Approach to the Synthesis of Furans

  摘要：

  The enol ether-olefin ring-closing metathesis reaction has been employed to generate 2,3-dihydrofurans that are equipped with a leaving group. These substrates are at the correct oxidation state to undergo an acid-catalyzed aromatization, and this strategy has been utilized to provide a mild and rapid route (four steps) to a range of novel 2,5-disubstituted furans.

  DOI：

  10.1021/ol062933r
• 作为产物：
  描述：

  乙基烯丙基醚 在 lead(II) chloride 四甲基乙二胺 、 仲丁基锂 、 四氯化钛 、 三乙胺 、 锌 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 1.5h， 生成 2-(2-ethoxy-1-(3-methylbut-1-en-2-yloxy)but-3-enyl)cyclopropane
  参考文献：
  名称：

  A Metathesis-Based Approach to the Synthesis of Furans

  摘要：

  The enol ether-olefin ring-closing metathesis reaction has been employed to generate 2,3-dihydrofurans that are equipped with a leaving group. These substrates are at the correct oxidation state to undergo an acid-catalyzed aromatization, and this strategy has been utilized to provide a mild and rapid route (four steps) to a range of novel 2,5-disubstituted furans.

  DOI：

  10.1021/ol062933r

文献信息

• A Metathesis-Based Approach to the Synthesis of Furans
  作者：Timothy J. Donohoe、Lisa P. Fishlock、Adam R. Lacy、Panayiotis A. Procopiou

  DOI：10.1021/ol062933r

  日期：2007.3.1

  The enol ether-olefin ring-closing metathesis reaction has been employed to generate 2,3-dihydrofurans that are equipped with a leaving group. These substrates are at the correct oxidation state to undergo an acid-catalyzed aromatization, and this strategy has been utilized to provide a mild and rapid route (four steps) to a range of novel 2,5-disubstituted furans.