1-[2-{3-chloropropoxy}-phenyl]-ethanone | 82827-55-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-{3-chloropropoxy}-phenyl]-ethanone
• 英文别名: 1-[2-(3-chloropropoxy)phenyl]ethanone；2'-(3-chloropropoxy)acetophenone
• CAS: 82827-55-2
• 化学式: C₁₁H₁₃ClO₂
• 分子量: 212.676
• InChiKey: ANIXAJRBFBWGGD-UHFFFAOYSA-N

物化性质

• 熔点：
  69-71 °C
• 沸点：
  324.0±17.0 °C(Predicted)
• 密度：
  1.123±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-氯苄基)哌嗪 、 1-[2-{3-chloropropoxy}-phenyl]-ethanone 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以58.8%的产率得到1-{2-[3-{4-(4-chlorobenzyl)piperazin-1-yl}propoxy]phenyl}ethanone
  参考文献：
  名称：

  Synthesis, evaluation and computational studies on a series of acetophenone based 1-(aryloxypropyl)-4-(chloroaryl) piperazines as potential atypical antipsychotics

  摘要：

  A series of 1-(aryloxypropyl)-4-(chloroaryl) piperazines have been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypy assays in mice. The compounds 11 and 12 have emerged as important lead compounds showing potential atypical antipsychotic profile. The physicochemical similarity of the new analogs with respect to standard drugs clozapine, ketanserin, ziprasidone and risperidone was assessed by calculating from a set of 10 physicochemical properties using software programs. The test compounds demonstrated good similarity values with respect to the standard drugs. The potential of these compounds to penetrate the blood brain barrier (log BB) was computed through an online software program and the values obtained for the compounds suggest a good brain permeation.

  DOI：

  10.1016/j.ejmech.2010.02.008
• 作为产物：
  描述：

  2'-羟基苯乙酮 、 1-溴-3-氯丙烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 以46%的产率得到1-[2-{3-chloropropoxy}-phenyl]-ethanone
  参考文献：
  名称：

  4-（二芳基羟甲基）-1- [3-（芳氧基）丙基]哌啶及结构相关化合物的合成及抗过敏活性。

  摘要：

  合成了一系列的4-（二芳基羟甲基）-1- [3-（芳氧基）丙基]哌啶，并评估了其抗过敏活性。几种类似物在被动足过敏症（PFA）检测中具有有效活性，PFA检测是一种IgE介导的模型，可用于检测具有抗过敏活性的化合物。特别是1- [4- [3- [4- [双（4-氟苯基）羟甲基] -1-哌啶基]丙氧基] -3-甲氧基苯基]乙酮（1，AHR-5333）比奥沙米特和特非那定在这种测定。

  DOI：

  10.1021/jm00121a022

文献信息

• 4-phenylpropyl-indoles having antiarythmic activity
  申请人：Roussel Uclaf

  公开号：US04853408A1

  公开（公告）日：1989-08-01

  Novel 4-phenylpropyl-indoles of the formula ##STR1## wherein R and R.sub.1 are individually selected from the group consisting of hydrogen, linear alkyl of 1 to 5 carbon atoms, branched alkyl of 3 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms cycloalkylalkyl of 4 to 7 carbon atoms and optionally substituted aralkyl of 7 to 12 carbon atoms or R.sub.1 and R taken together with the nitrogen atom form an optionally unsaturated heterocycle containing another heteroatom selected from the group consisting of oxygen, sulfur and nitrogen optionally substituted with a member of the group consisting of alkyl of 1 to 5 carbon atoms, phenyl, naphthyl and aralkyl of 7 to 12 carbon atoms, a together with b forms .dbd.0 or a together with c form a carbon-carbon bond, b is hydrogen or with a forms .dbd.0, c is hydrogen or with a forms a carbon-carbon bond, the dotted line is an optional carbon-carbon bond, A is --(CH.sub.2).sub.n --, is an integer from 2 to 5, R.sub.2 is selected from the group consisting of hydrogen, linear alkyl of 1 to 5 carbon atoms and branched alkyl of 3 to 5 carbon atoms, x is hydrogen or -OH or together with y forms .dbd.0 and y is hydrogen or together with x forms .dbd.0 and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable antiarythmic properties and blocking of slow calcicosodic canals.

  4-苯基丙基吲哚类新化合物的结构式为##STR1##其中R和R.sub.1分别选择自由基团，包括氢、1至5个碳原子的直链烷基、3至5个碳原子的支链烷基、3至7个碳原子的环烷基、4至7个碳原子的环烷基烷基，或者可选择取代的7至12个碳原子的芳基或R.sub.1和R结合在一起与氮原子形成一个可选择不饱和的含有另一个氧、硫和氮等异原子的杂环，可选择取代为1至5个碳原子的烷基、苯基、萘基和7至12个碳原子的芳基，a和b形成.dbd.0或a和c形成一个碳-碳键，b是氢或与a形成.dbd.0，c是氢或与a形成一个碳-碳键，虚线为可选择的碳-碳键，A为--(CH.sub.2).sub.n--，其中n为2至5的整数，R.sub.2选择自由基团，包括氢、1至5个碳原子的直链烷基和3至5个碳原子的支链烷基，x为氢或-OH或与y形成.dbd.0，y为氢或与x形成.dbd.0，以及它们的无毒、药学上可接受的酸盐具有显著的抗心律失常特性和阻断慢性钙钠通道。
• US4853408A
  申请人：——

  公开号：US4853408A

  公开（公告）日：1989-08-01
• US4950674A
  申请人：——

  公开号：US4950674A

  公开（公告）日：1990-08-21
• Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl)piperidines and structurally related compounds
  作者：David A. Walsh、Stephen K. Franzyshen、John M. Yanni

  DOI：10.1021/jm00121a022

  日期：1989.1

  A series of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines was synthesized and evaluated for antiallergy activity. Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity. In particular 1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl] propoxy]-3-methoxyphenyl]ethanone

  合成了一系列的4-（二芳基羟甲基）-1- [3-（芳氧基）丙基]哌啶，并评估了其抗过敏活性。几种类似物在被动足过敏症（PFA）检测中具有有效活性，PFA检测是一种IgE介导的模型，可用于检测具有抗过敏活性的化合物。特别是1- [4- [3- [4- [双（4-氟苯基）羟甲基] -1-哌啶基]丙氧基] -3-甲氧基苯基]乙酮（1，AHR-5333）比奥沙米特和特非那定在这种测定。
• Synthesis, evaluation and computational studies on a series of acetophenone based 1-(aryloxypropyl)-4-(chloroaryl) piperazines as potential atypical antipsychotics
  作者：Alka Bali、Komal Sharma、Abhishek Bhalla、Suman Bala、Dinesh Reddy、Anant Singh、Anil Kumar

  DOI：10.1016/j.ejmech.2010.02.008

  日期：2010.6

  A series of 1-(aryloxypropyl)-4-(chloroaryl) piperazines have been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypy assays in mice. The compounds 11 and 12 have emerged as important lead compounds showing potential atypical antipsychotic profile. The physicochemical similarity of the new analogs with respect to standard drugs clozapine, ketanserin, ziprasidone and risperidone was assessed by calculating from a set of 10 physicochemical properties using software programs. The test compounds demonstrated good similarity values with respect to the standard drugs. The potential of these compounds to penetrate the blood brain barrier (log BB) was computed through an online software program and the values obtained for the compounds suggest a good brain permeation.