diethyl 2-(amino(4-methoxyphenyl)methylene)malonate | 142892-71-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: diethyl 2-(amino(4-methoxyphenyl)methylene)malonate
• 英文别名: diethyl 2-[amino(4-methoxyphenyl)methylene]malonate；diethyl 4-methoxyphenylaminomethylenemalonate；Diethyl [amino(4-methoxyphenyl)methylidene]propanedioate；diethyl 2-[amino-(4-methoxyphenyl)methylidene]propanedioate
• CAS: 142892-71-5
• 化学式: C₁₅H₁₉NO₅
• 分子量: 293.32
• InChiKey: LQYTVOZVGTZQHC-UHFFFAOYSA-N

物化性质

• 沸点：
  428.9±45.0 °C(Predicted)
• 密度：
  1.169±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  87.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  diethyl 2-(amino(4-methoxyphenyl)methylene)malonate 以 二苯醚 、 乙酸乙酯 为溶剂， 以45%的产率得到4-羟基-6-甲氧基喹啉-3-羧酸乙酯
  参考文献：
  名称：

  Quinoline derivatives and medicinal use thereof

  摘要：

  由以下式（1）表示的喹啉衍生物，可以使作为细胞核转录因子的PPAR&agr;或&ggr;功能强大且毒性低。通过使用这种化合物作为活性成分，可以提供与PPAR&agr;或&ggr;相关的各种疾病的预防或治疗剂。

  公开号：

  US20030212100A1
• 作为产物：
  描述：

  diethyl (E)-2-chloro-2-[(chloroimino)(4-methoxyphenyl)methyl]malonate 在 锌 作用下， 以 甲醇 为溶剂， 以80%的产率得到diethyl 2-(amino(4-methoxyphenyl)methylene)malonate
  参考文献：
  名称：

  PhICl2-Mediated Conversion of Enamines into α,N-Dichloroimines and Their Reverse Conversion Mediated by Zinc in Methanol

  摘要：

  Treatment of enamine compounds with iodobenzene dichloride (PhICl2) conveniently gives a variety of alpha,N-dichloroimines in high yields. This approach allows the double insertion of the chloro moiety, which is postulated to take place via the iodobenzene dichloride mediated oxidative alpha-chlorination of the enamine substrates followed by further N-chlorination of the imine intermediates. Furthermore, the obtained alpha,N-dichloroimines could be converted reversely into the original enamines under reductive conditions using zinc in methanol.

  DOI：

  10.1055/s-0033-1341067

文献信息

• Indium-Mediated Blaise-Type Reaction of Bromomalonates with Nitriles and Isocyanates
  作者：Gerhard Hilt、Emre Babaoglu、Klaus Harms

  DOI：10.1055/s-0035-1561973

  日期：——

  The indium-mediated Blaise-type reaction of bromomalonates with nitriles and isocyanates is described. The choice of the solvent is crucial for the successful reaction; the dependency on dichloromethane proved to be nonplussed. The reaction with nitriles led to the corresponding β-enamino diesters in moderate to good yields. The conversion with isocyanates generated carbamoyl malonates in good to excellent

  描述了溴丙二酸酯与腈和异氰酸酯的铟介导的 Blaise 型反应。溶剂的选择是反应成功的关键；事实证明，对二氯甲烷的依赖是无法理解的。与腈的反应以中等至良好的产率产生相应的 β-烯氨基二酯。与异氰酸酯的转化以良好到极好的产率生成氨基甲酰基丙二酸酯。两种反应都耐受有关电子性质的各种官能团。此外，由异氰酸异氰酸甲酯或异氰酸二异丙基苯酯引起的起始材料中的空间位阻也能很好地耐受。此外，还描述了一个连续的三组分一锅反应序列，用于形成 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates，使该领域的未来研究成为可能。
• QUINOLINE DERIVATIVES AND MEDICINAL USE THEREOF
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1266888A1

  公开（公告）日：2002-12-18

  A quinoline derivative represented by the following formula (1): allows PPARα or γ which is an intranuclear transcription factor, to function strongly and is low in toxicity. By using this compound as an active ingredient, there can be provided a preventive or therapeutic agent for various diseases related to PPARα or γ.

  由下式（1）代表的喹啉衍生物： 可使作为核内转录因子的 PPARα 或 γ 发挥强大的功能，且毒性低。使用这种化合物作为活性成分，可以提供一种预防或治疗与 PPARα 或 γ 有关的各种疾病的药物。
• PhICl2-Mediated Conversion of Enamines into α,N-Dichloroimines and Their Reverse Conversion Mediated by Zinc in Methanol
  作者：Yunfei Du、Kang Zhao、Linlin Tang、Daisy Zhang-Negrerie

  DOI：10.1055/s-0033-1341067

  日期：——

  Treatment of enamine compounds with iodobenzene dichloride (PhICl2) conveniently gives a variety of alpha,N-dichloroimines in high yields. This approach allows the double insertion of the chloro moiety, which is postulated to take place via the iodobenzene dichloride mediated oxidative alpha-chlorination of the enamine substrates followed by further N-chlorination of the imine intermediates. Furthermore, the obtained alpha,N-dichloroimines could be converted reversely into the original enamines under reductive conditions using zinc in methanol.
• Quinoline derivatives and medicinal use thereof
  申请人：——

  公开号：US20030212100A1

  公开（公告）日：2003-11-13

  A quinoline derivative represented by the following formula (1): 1 allows PPAR&agr; or &ggr; which is an intranuclear transcription factor, to function strongly and is low in toxicity. By using this compound as an active ingredient, there can be provided a preventive or therapeutic agent for various diseases related to PPAR&agr; or &ggr;.

  由以下式（1）表示的喹啉衍生物，可以使作为细胞核转录因子的PPAR&agr;或&ggr;功能强大且毒性低。通过使用这种化合物作为活性成分，可以提供与PPAR&agr;或&ggr;相关的各种疾病的预防或治疗剂。