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(+)-Methyl-α-D-talopyranosid | 51224-40-9

中文名称
——
中文别名
——
英文名称
(+)-Methyl-α-D-talopyranosid
英文别名
methyl α-D-talopyranoside;Me α-D-Tal;Methyl-α-D-talopyranosid;(2R,3R,4S,5S,6S)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol
(+)-Methyl-α-D-talopyranosid化学式
CAS
51224-40-9
化学式
C7H14O6
mdl
——
分子量
194.185
InChiKey
HOVAGTYPODGVJG-JAIWFUSLSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    389.1±42.0 °C(Predicted)
  • 密度:
    1.47±0.1 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    -2.2
  • 重原子数:
    13
  • 可旋转键数:
    2
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    1.0
  • 拓扑面积:
    99.4
  • 氢给体数:
    4
  • 氢受体数:
    6

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Oligosaccharide recognition by antibodies: Synthesis and evaluation of talose oligosaccharide analogues
    作者:T L Lowary、E Eichler、D R Bundle
    DOI:10.1139/v02-118
    日期:2002.8.1

    A series of monosaccharide (4–6), disaccharide (3,7–12), and trisaccharide (13–15) analogs of the native ligand 2, which fills the binding site of monoclonal antibody Se 155.4, have been synthesized and their bioactivity measured by solid- and solution-phase assays. The syntheses of disaccharide analogs sought to replace galactose by various alkyl groups at the O-2 position of mannose. The activity of one of these O-2 alkyl analogs was 75% of that observed for the trisaccharide and points to only weak net bonding between the solvent exposed galactose residue and the antibody binding site. The synthesis of talose analogs 13 and 14, where the mannose or galactose residues of 2 were replaced by talose produced ligands with activities from one-third to one-half of that seen for the native ligand 2. These activity changes did not exhibit discernable correlations with the ability of talose to disrupt water of solvation.Key words: abequose, 3,6-dideoxy-D-xylo-hexose, talose disaccharide and trisaccharide, antibody oligosaccharide interactions, molecular recognition of carbohydrates, water in antibody complexes, Salmonella LPS, monoclonal antibody Se 155.4, bacterial O-antigen.

    一系列单糖(4-6)、二糖(3、7-12)和三糖(13-15)类似物已经合成,它们是原生配体2的类似物,填充了单克隆抗体Se 155.4的结合位点,并通过固相和溶液相测定了它们的生物活性。二糖类似物的合成旨在将半乳糖替换为甘露糖的O-2位置的各种烷基。其中一种O-2烷基类似物的活性为观察到的三糖活性的75%,表明溶剂暴露的半乳糖残基与抗体结合位点之间只有弱的净键合。通过将原生配体2的甘露糖残基替换为甜菜糖合成了甜菜糖类似物13和14,这些配体的活性为原生配体2的三分之一到一半。这些活性变化与甜菜糖破坏溶剂的能力之间没有明显的相关性。关键词:阿贝酮,3,6-二去氧-D-木糖-己糖,甜菜糖二糖和三糖,抗体寡糖相互作用,碳水化合物的分子识别,抗体复合物中的,沙门氏菌LPS,单克隆抗体Se 155.4,细菌O抗原。
  • POLYMER STABILIZER
    申请人:KIMURA Yoshikazu
    公开号:US20100179253A1
    公开(公告)日:2010-07-15
    A polymer stabilizer comprising the following alkoxy compound: the alkoxy compound: a compound obtained by alkoxylating at least one hydroxyl group contained in a compound of the following formula (1) containing one formyl group or carbonyl group and (n− 1 ) hydroxyl groups in the molecule with an alkyl group having 1 to 12 carbon atoms: C n H 2n O n (1) (wherein, n represents an integer of 3 or more).
    一种聚合物稳定剂,包含以下烷氧基化合物:所述烷氧基化合物是通过将含有以下通式(1)中的一个甲酰基或羰基以及分子中(n-1)个羟基的化合物中的至少一个羟基进行烷氧基化而得到的化合物,其中烷基团含有1至12个碳原子:CnH2nOn(1)(其中,n代表3或以上的整数)。
  • 1 : 1 Adduct Ion Formation of Permethylated Monosaccharides with Organic Cations in FAB Mass Spectrometry
    作者:Masami Sawada、Li Ouyang、Yoshio Takai、Hitoshi Yamada、Motohiro Shizuma、Takeshi Kinoshita、Tomoko Mochizuki、Terukiyo Hanafusa
    DOI:10.1246/bcsj.64.1243
    日期:1991.4
    the OCH3 configurational effects of M on (M+A)+ adduct ion formation. The findings can be interpreted in terms of multisite electrostatic interaction of oxygens with the cation. Coupled with the results of gas-phase behavior by FABMS/MS(CAD), solution behavior by 1H NMR, and model calculations by MNDO, the characteristic structure of the 1 : 1 adduct ion is deduced as host-guest type association between
    已在定量 FAB 质谱法中检查了一系列全甲基化单糖 (M; Ia–Ih) 和有机或属阳离子 (A+) 之间 1:1 的加合离子形成。在相同 FABMS 条件下的仔细比较中,相对 (M+A)+ 峰强度以单糖的以下顺序增加,并进一步以几乎相同的程度增加,尽管使用了三种不同的阳离子,例如辛基,(甲氧基羰基) ) 甲基钾离子:β-Glc<α-Glc<α-Gal<β-Gal≤α-Man<β-Man<α-Tal<β-Tal。顺序和阳离子独立性清楚地表明 OCH3 构型M 对 (M+A)+ 加合离子形成的影响。这些发现可以解释为氧与阳离子的多位点静电相互作用。
  • A mild and efficient approach for the regioselective silyl-mediated protection–deprotection of C-4 hydroxyl group on carbohydrates
    作者:Andrea Graziani、Pietro Passacantilli、Giovanni Piancatelli、Simona Tani
    DOI:10.1016/s0040-4039(01)00611-6
    日期:2001.6
    This protocol shows high efficiency on intermediates, such as 1a, which contain a TIPS protective group at C-6 and necessarily a benzoyl group at C-4. Treatment of 1a with TBAF cleaves the TIPS protecting group and gives rise to an intramolecular migration of the benzoyl group at C-4 to the less crowded C-6 position.
    报道了区域选择性路线,其使得六喃糖及其衍生物的游离4-OH基团容易且快速地可用。该协议显示出对中间体(例如1a)的高效率,该中间体在C-6处包含TIPS保护基,在C-4处必含苯甲酰基。用TBAF处理1a可裂解TIPS保护基并引起C-4处苯甲酰基向较不拥挤的C-6位置的分子内迁移。
  • THERMOPLASTIC POLYMER COMPOSITION AND PROCESSING STABILISER
    申请人:Kimura Yoshikazu
    公开号:US20130032756A1
    公开(公告)日:2013-02-07
    The present invention provides a thermoplastic polymer composition containing a particular phenol compound or organic phosphoric compound, compound (9) which is compound (9a) represented by C m H 2m O m wherein m is an integer of not less than 3 and not more than 10, and having one aldehyde group or ketone group and m−1 hydroxy groups with at least one hydroxy group having been replaced by an alkoxy group represented by —OR 26 wherein R 26 is a C 1-12 alkyl group, and a thermoplastic polymer, and a processing stabilizer containing a particular phenol compound or organic phosphoric compound, and compound (9). A combined use of a particular phenol compound or organic phosphoric compound and compound (9) can improve processing stability of a thermoplastic polymer composition.
    本发明提供了一种热塑性聚合物组合物,其中包含特定的化合物或有机化合物、化合物(9),该化合物(9)表示为CmH2mOm,其中m是不小于3且不大于10的整数,具有一个醛基或酮基和m-1个羟基,其中至少一个羟基已被一个表示为—OR26的烷氧基所取代,其中R26是C1-12烷基,以及一种热塑性聚合物和一种加工稳定剂,该加工稳定剂包含特定的化合物或有机化合物和化合物(9)。特定的化合物或有机化合物和化合物(9)的联合使用可以提高热塑性聚合物组合物的加工稳定性。
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