3-(3-氨基丙基)丙酮缩甘油 | 131606-42-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-(3-氨基丙基)丙酮缩甘油
• 英文名称: 3-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propan-1-amine
• 英文别名: 3-(2,2-dimethyl-[1,3]dioxolan-4-yl-methoxy)-propylamine；3-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethoxy)-propylamine
• CAS: 131606-42-3
• 化学式: C₉H₁₉NO₃
• mdl: MFCD06740223
• 分子量: 189.255
• InChiKey: ALTVLQHLIFBSJJ-UHFFFAOYSA-N

物化性质

• 沸点：
  279.9±25.0 °C(Predicted)
• 密度：
  0.996±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  53.7
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2932999099
• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  3-(3-氨基丙基)丙酮缩甘油 在 盐酸 、 N-羟基丁二酰亚胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 [5-[3-(2,3-Dihydroxypropoxy)propylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate
  参考文献：
  名称：

  Fluorescent dye phosphoramidite labelling of oligonucleotides

  摘要：

  A 5-carboxyfluorescein (FAM) phosphoramidite reagent has been synthesized for use on automated DNA synthesizers, to prepare fluorescent dye labelled oligonucleotides. Oligonucleotides can be labelled at any site in a sequence and multiple labelled. The FAM dye can also be coupled to a polystyrene synthesis support to prepare 3' fluorescent labelled oligonucleotides.

  DOI：

  10.1016/s0040-4039(00)61181-4
• 作为产物：
  描述：

  3-(2,2-dimethyl-[1,3]dioxolan-4-yl-methoxy)-propionitrile 在 sodium tetrahydroborate 、 cobalt(II) chloride hexahydrate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以50%的产率得到3-(3-氨基丙基)丙酮缩甘油
  参考文献：
  名称：

  固载化的核酸适配体的连接臂及其制备方法和应用

  摘要：

  本发明涉及核酸适配体技术领域，公开了固载化的核酸适配体的连接臂及其制备方法和应用。该连接臂具有式1所示结构；其中，R1和R2各自独立地选自直链或支链的C1‑C10的烷基，R为氨基保护基团，n为2‑6的整数。与现有技术相比，本发明具有以下有益效果：1)采用本发明提供的固载化的核酸适配体的连接臂在核酸适配体合成最后一步用浓氨水切除CPG时选择性高，只可能得到一种产物；2)所述核酸适配体连接臂上只留下一个仲醇，不易发生副反应；3)制备该固载化的核酸适配体的连接臂的原料为丙酮缩甘油，容易获得。

  公开号：

  CN111039809B

文献信息

• NUCLEIC ACID MONOMERS WITH 2'-CHEMICAL MOIETIES
  申请人：Laikhter Andrei

  公开号：US20070218490A1

  公开（公告）日：2007-09-20

  The invention provides nucleic acid monomers with a 2′-modification that are useful for the incorporation of dyes or blocking groups. The monomers can be incorporated on the 3′-end of a dual labeled probe to inhibit PCR polymerase extension during PCR. The polymerase is inhibited from extending the probe at the 3′-hydroxyl group when the monomer is present; there is no need to add a chemical moiety to the 3′-hydroxyl or remove the 3′-hydroxyl. The monomers can also be incorporated internally or at the 5′-end of the oligonucleotide. A detectable label, such as a fluorescent or quenching dye, can be incorporated on the 2′-position of such monomers.

  该发明提供了具有2'-修饰的核酸单体，可用于染料或阻断基团的引入。这些单体可以被合并到双标记探针的3'-末端，以在PCR过程中抑制PCR聚合酶的延伸。当单体存在时，聚合酶被抑制在3'-羟基团上延伸探针；无需向3'-羟基团添加化学基团或去除3'-羟基团。这些单体也可以在寡核苷酸的内部或5'-末端进行合并。可以在这些单体的2'-位置上合并可检测的标记，如荧光染料或猝灭染料。
• 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides
  申请人：Luk Kin-Chun

  公开号：US20050256154A1

  公开（公告）日：2005-11-17

  Disclosed are novel 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid amides, and their pharmaceutically acceptable salts and esters, that are selective inhibitors of KDR and/or FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular solid cancerous tumors of the breast, colon, lung and prostate. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer using these compounds.

  本文披露了一种新颖的4-氨基噻吩[3,2-c]吡啶-7-羧酸酰胺，以及它们的药用盐和酯，这些化合物是KDR和/或FGFR激酶的选择性抑制剂。这些化合物及其药用盐是抗增殖剂，可用于治疗或控制实体肿瘤，特别是乳腺、结肠、肺和前列腺的实体癌性肿瘤。还披露了含有这些化合物的药物组合物和使用这些化合物治疗癌症的方法。
• Synthesis of Novel Coumarin-Based Fluorescent Probes
  作者：Ivana Kosiova、Pavol Kois

  DOI：10.1135/cccc20070996

  日期：——

  We report on synthesis of new fluorescent probes suitable for site-specific incorporation into oligonucleotides. Coumarin derivatives were used as sensitive fluorescent labels and were attached to glycerol unit by two types of linkers as potential building blocks for oligonucleotide synthesis. Spectral characteristics of the functionalized coumarin building blocks were measured.

  我们报告了合成适用于特定位置嵌入寡核苷酸的新荧光探针。香豆素衍生物被用作敏感的荧光标记，并通过两种类型的连接剂连接到甘油单元，作为寡核苷酸合成的潜在构建块。测量了功能化香豆素构建块的光谱特性。
• Nucleotides. Part LXXVI
  作者：Evgeny Kvassiouk、Ramamurthy Charubala、Wolfgang Pfleiderer

  DOI：10.1002/hlca.200900413

  日期：——

  A series of new fluorescing 8‐(6‐hydroxyhexyl)isoalloxazine (=8‐(6‐hydroxyhexyl)benzo[g]pteridine‐2,4(1H,3H)‐dione) derivatives 4–13 were synthesized from 6‐[(6‐hydroxyhexyl)amino]uracil (2) with 1‐chloro‐4‐nitrosobenzene via 8‐chloro‐10‐(6‐hydroxyhexyl)isoalloxazine (3) and subsequent substitution of the Cl‐atom of 3 by various amines (Scheme). Analogously, 8‐substituted 10‐3‐[(2,2‐dimethyl‐1,3‐

  一系列新荧光8-（6-羟基己基）异咯嗪（= 8-（6-羟基己基）苯并[克]蝶啶-2,4（ħ，3 ħ） -二酮）衍生物的4 - 13，从6-合成[（6-羟基己基）氨基]尿嘧啶（2）与1-氯-4-硝基苯经由8-氯-10-（6-羟基己基）异咯嗪（3）和体的C1-原子的后续取代3由各种胺（方案）。类似地，8-取代的10- 3 - [（2,2-二甲基-1,3-二氧戊环-4-基）甲氧基]丙基}异咯嗪19,20，和23 - 25制备其上脱保护得到相应的10- [3-（2,3-二羟基）丙基]咯嗪21,22，和26 - 28。其转化成3“ - Ö - （4,4'-二甲氧基三苯甲基）衍生物29 - 33和随后转化成相应的2” - （2-氰乙基Ñ，Ñ -diisopropylphosphoramidites）34 - 38导致了对寡核苷酸新的构建块合成。一系列带有发荧光异异恶嗪37的21-mer寡脱氧核糖核苷
• Fluorous Oligonucleotide Reagents and Affinity Purification of Oligonucleotides
  申请人：Berry David A.

  公开号：US20100087634A1

  公开（公告）日：2010-04-08

  Fluorous-tagged oligonucleotide reagents and an oligonucleotide purification methodology making use thereof, the method comprising: Synthesizing oligonucleotides using oligonucleotide reagents each bearing at least one fluorous group to yield a mixture of synthesis products and reagents, the mixture including at least one target synthesized oligonucleotide bearing at least one fluorous group; passing the mixture through a separation medium having an affinity for the at least one fluorous group so that the target synthesized oligonucleotide bearing at least one fluorous group is adsorbed by the separation medium; washing the separation medium with at least a first solvent to selectively dissociate therefrom substantially all synthesis products and reagents of the heterogenous mixture other than the at least one target synthesized oligonucleotide bearing at least one fluorous group; and subsequently dissociating the at least one synthesized oligonucleotide from the separation medium, with or without the fluorous group.

  含氟标记的寡核苷酸试剂及其利用的寡核苷酸纯化方法，该方法包括：使用每个带有至少一个氟基团的寡核苷酸试剂合成寡核苷酸，以产生一种合成产物和试剂的混合物，其中包括至少一种带有至少一个氟基团的目标合成寡核苷酸；将混合物通过具有亲和力的分离介质，使带有至少一个氟基团的目标合成寡核苷酸被分离介质吸附；使用至少一种第一溶剂清洗分离介质，以选择性地分离除带有至少一个氟基团的目标合成寡核苷酸之外的异质混合物中的所有合成产物和试剂；随后将至少一个合成寡核苷酸与或不与氟基团从分离介质中解离。