4-tert-Butyl-N-[5-(3-methoxy-phenoxy)-6-(4-oxo-butoxy)-pyrimidin-4-yl]-benzenesulfonamide | 202287-80-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-tert-Butyl-N-[5-(3-methoxy-phenoxy)-6-(4-oxo-butoxy)-pyrimidin-4-yl]-benzenesulfonamide
• 英文别名: 4-(tert-butyl)-N-(5-(3-methoxyphenoxy)-6-(4-oxobutoxy)pyrimidin-4-yl)benzenesulfonamide；4-tert-butyl-N-[5-(3-methoxyphenoxy)-6-(4-oxobutoxy)pyrimidin-4-yl]benzenesulfonamide
• CAS: 202287-80-7
• 化学式: C₂₅H₂₉N₃O₆S
• 分子量: 499.588
• InChiKey: ZBMWELXXTGBMQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  4-tert-Butyl-N-[5-(3-methoxy-phenoxy)-6-(4-oxo-butoxy)-pyrimidin-4-yl]-benzenesulfonamide 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以38%的产率得到4-tert-butyl-N-[6-(4-hydroxyiminobutoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide
  参考文献：
  名称：

  Synthesis and structure–activity relationships of potent and orally active sulfonamide ETB selective antagonists

  摘要：

  The synthesis and structure-activity relationships of a series of N-pyrimidinyl benzenesulfonamides as ETB selective antagonists are described. N-Isoxazolyl benzenesulfonamide 1a. previously reported,(1) was selected as a lead compound, and isosteric replacement of the isoxazole ring of la with a pyrimidine ring led to the discovery of the highly potent ETB selective antagonist 6e with oral bioavailability. Modification of the terminal aldehyde group at the 6-position of the pyrimidine ring was investigated, and malonate 15b and acylhydrazone 16f were found to be equipotent to aldehyde 6e. Compound 6e showed ETB antagonistic activity on in vivo evaluation. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00305-9
• 作为产物：
  描述：

  5-(3-methoxyphenoxy)-1H-pyrimidin-4,6-dione 在 2,3,5-三甲基吡啶 、 sodium hydride 、 pyridinium chlorochromate 、 三氯氧磷 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 13.0h， 生成 4-tert-Butyl-N-[5-(3-methoxy-phenoxy)-6-(4-oxo-butoxy)-pyrimidin-4-yl]-benzenesulfonamide
  参考文献：
  名称：

  Synthesis and structure–activity relationships of potent and orally active sulfonamide ETB selective antagonists

  摘要：

  The synthesis and structure-activity relationships of a series of N-pyrimidinyl benzenesulfonamides as ETB selective antagonists are described. N-Isoxazolyl benzenesulfonamide 1a. previously reported,(1) was selected as a lead compound, and isosteric replacement of the isoxazole ring of la with a pyrimidine ring led to the discovery of the highly potent ETB selective antagonist 6e with oral bioavailability. Modification of the terminal aldehyde group at the 6-position of the pyrimidine ring was investigated, and malonate 15b and acylhydrazone 16f were found to be equipotent to aldehyde 6e. Compound 6e showed ETB antagonistic activity on in vivo evaluation. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00305-9

文献信息

• ETBR ANTAGONIST COMPOUNDS, COMPOSITIONS, AND USES
  申请人：ENB Therapeutics, Inc.

  公开号：EP3746110A1

  公开（公告）日：2020-12-09
• [EN] ETBR ANTAGONIST COMPOUNDS, COMPOSITIONS, AND USES<br/>[FR] COMPOSÉS ANTAGONISTES D'ETBR, COMPOSITIONS ET UTILISATIONS
  申请人：ENB THERAPEUTICS INC

  公开号：WO2019191721A1

  公开（公告）日：2019-10-03

  Disclosed herein are ETBR antagonist compounds, pharmaceutical compositions thereof, methods for treating cancers, and methods of forming tertiary lymphoid organs.
• Synthesis and structure–activity relationships of potent and orally active sulfonamide ETB selective antagonists
  作者：Yasuhiko Kanda、Yasuyuki Kawanishi、Katsuo Oda、Teruo Sakata、Shin-ichi Mihara、Kenji Asakura、Toshiyuki Kanemasa、Mitsuyoshi Ninomiya、Masafumi Fujimoto、Toshiro Konoike

  DOI：10.1016/s0968-0896(00)00305-9

  日期：2001.4

  The synthesis and structure-activity relationships of a series of N-pyrimidinyl benzenesulfonamides as ETB selective antagonists are described. N-Isoxazolyl benzenesulfonamide 1a. previously reported,(1) was selected as a lead compound, and isosteric replacement of the isoxazole ring of la with a pyrimidine ring led to the discovery of the highly potent ETB selective antagonist 6e with oral bioavailability. Modification of the terminal aldehyde group at the 6-position of the pyrimidine ring was investigated, and malonate 15b and acylhydrazone 16f were found to be equipotent to aldehyde 6e. Compound 6e showed ETB antagonistic activity on in vivo evaluation. (C) 2001 Elsevier Science Ltd. All rights reserved.