3-methylbutyl propargyl ether | 108420-44-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methylbutyl propargyl ether
• 英文别名: isopentyl-prop-2-ynyl ether；3-Isopentyloxy-propin；Isopentyl-prop-2-inyl-aether；Isoamyl-propargyl-aether；3-Methyl-1-prop-2-ynoxybutane；3-methyl-1-prop-2-ynoxybutane
• CAS: 108420-44-6
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: JTZHNUOBOFKYHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-methylbutyl propargyl ether 在 硫酸 、 mercury(II) oxide 作用下， 生成 isopentyloxy-acetone
  参考文献：
  名称：

  Wwedenskii, Ukrainskij Khimicheskij Zhurnal, 1959, vol. 25, p. 203

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(异戊氧基)-1,2-丙烷二醇 在 磷化氢 、 氢氧化钾 、 溴 作用下， 生成 3-methylbutyl propargyl ether
  参考文献：
  名称：

  Wwedenskii, Ukrainskij Khimicheskij Zhurnal, 1959, vol. 25, p. 203

  摘要：

  DOI：

文献信息

• FUNCTIONALIZED PEGYLATED CYANINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
  申请人：BroadPharm

  公开号：US20170197916A1

  公开（公告）日：2017-07-13

  Provided herein are functionalized pegylated cyanine compounds containing a reactive group suitable for labeling a biomolecule or pharmaceutical compositions and methods of use thereof. In one embodiment, the compounds are based on formula I shown below. In other embodiments, the compounds can be pegylated at one or more of the following locations R 1 , R 4 , R 6 , R 9 , or L.

  本文提供了含有适用于标记生物分子或药物组合物的反应性基团的功能化聚乙二醇化青霉素化合物，以及其使用方法。在一种实施方式中，该化合物基于下面所示的I式。在其他实施方式中，该化合物可以在以下位置之一或多个位置进行聚乙二醇化：R1、R4、R6、R9或L。
• A Chemoenzymatic Cascade Combining a Hydration Catalyst with an Amine Dehydrogenase: Synthesis of Chiral Amines
  作者：Fengwei Chang、Chengyi Wang、Qipeng Chen、Yongjin Zhang、Guohua Liu

  DOI：10.1002/anie.202114809

  日期：2022.3

  carbene complex was combined with a free amine dehydrogenase (GkAmDH) as a co-catalyst, enabling a cascade synthetic route to directly access chiral amines from propargylethers. This process, combining an initial gold carbene catalyzed hydration of propargylethers to ketones followed by a subsequent reductive amination, produces a wide range of chiral amines in high yields and excellent enantioselectivities

  封装的金卡宾复合物与作为助催化剂的游离胺脱氢酶 ( Gk AmDH) 结合，实现了从炔丙基醚直接获取手性胺的级联合成路线。该过程将最初的金卡宾催化的炔丙基醚水合为酮，然后进行还原胺化，以高产率和优异的对映选择性生产各种手性胺。
• [EN] 4-(3,3-DIHALO-ALLYLOXY)PHENOXY ALKYL DERIVATIVES<br/>[FR] DERIVES 4-(3,3-DIHALO-ALLYLOXY)PHENOXYALKYLE
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2004002943A1

  公开（公告）日：2004-01-08

  Compounds of formula (I), wherein A1, A2 and A3 are each independently of the others a bond or a C1-C6alkylene bridge; A4 is a C1-C6alkylene bridge; Di s CH or N; W is, for example, O, NR7 or S; T is, for example, a bond, O, NH or NR7; Q is O, NR7, S, SO or SO2; Y is O, NR7, S, SO, or SO2; X1 and X2 are each independently of the other fluorine, chlorine or bromine; R1, R2 and R3 ar, for example, H, halogen, CN, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkylcarbonyl or C2-C6alkenyl; R4 is, for example, H, halogen, CN, nitro or C1-C6alkyl; R5 and R6 are, for example, H, CN, OH, C1-C6alkyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C6alkyl, C1-C6 haloalky, C1-C6alkoxy or C1-C6haloalkoxy; R7 is H, C1-C6alkyl, C1-C6alkoxyalkyl or C1-C6alkylcarbonyl; k, when D is nitrogen, is 1, 2 or 3; or, when D is CH, is 1, 2, 3 or 4; and m is 1 or 2; and, where applicable, their possible E/Z isomers, E/Z isomeric mixtures and/or tautomers, in each case in free form or in salt form, a process for the preparation of those compounds and their use, pesticidal compositions in which the active ingredient has been selected from those compounds or an agrochemically acceptable salt thereof, a process for the preparation of those compositions and their use, plant propagation material treated with those compositions, and a method of controlling pests.

  化学式为（I）的化合物，其中A1、A2和A3各自独立地为键或C1-C6烷基桥；A4为C1-C6烷基桥；Di为CH或N；W为例如O、NR7或S；T为例如键、O、NH或NR7；Q为O、NR7、S、SO或SO2；Y为O、NR7、S、SO或SO2；X1和X2各自独立地为氟、氯或溴；R1、R2和R3例如为H、卤素、CN、硝基、C1-C6烷基、C1-C6卤代烷基、C1-C6烷基羰基或C2-C6烯基；R4例如为H、卤素、CN、硝基或C1-C6烷基；R5和R6例如为H、CN、OH、C1-C6烷基、C3-C8环烷基、C3-C8环烷基-C1-C6烷基、C1-C6卤代烷氧基或C1-C6烷氧基；R7为H、C1-C6烷基、C1-C6烷氧基烷基或C1-C6烷基羰基；当D为氮时，k为1、2或3；或当D为CH时，k为1、2、3或4；m为1或2；适用时，它们的可能的E/Z异构体、E/Z异构体混合物和/或互变异构体，均为自由形式或盐形式，制备这些化合物的方法及其用途，所述活性成分被选自这些化合物或其农药学上可接受的盐的杀虫剂组合物，制备这些组合物的方法及其用途，用这些组合物处理的植物繁殖材料，以及控制害虫的方法。
• ACTIVITY-BASED PROBES FOR THE UROKINASE PLASMINOGEN ACTIVATOR
  申请人：Augustyns Koen

  公开号：US20140079632A1

  公开（公告）日：2014-03-20

  The present invention relates to selective trypsine-like serine protease activity-based probes, in particular urokinase plasminogen activator-activity based probes, the use thereof and methods for detecting selective urokinase activity by making use of said probes.

  本发明涉及选择性胰蛋白酶样丝氨酸蛋白酶活性探针，特别是以尿激酶纤溶酶原激活剂活性为基础的探针，其使用和利用该探针检测选择性尿激酶活性的方法。
• Ruthenium-Catalyzed Hydrosilylation of 1-Alkynes with Novel Regioselectivity
  作者：Yukio Kawanami、Yoshiya Sonoda、Takashi Mori、Keiji Yamamoto

  DOI：10.1021/ol026089q

  日期：2002.8.1

  [GRAPHIC]A ruthenium catalyst precursor bearing a bulky and electron-donating pentamethylcyclopentadienyl (Cp-*) ligand, typically (CpRuH3)-Ru-*(PPh3), mediates hydrosilylation of several 1-alkynes with novel regioselectivity to give preferentially 2-silyl-1-alkenes.