乙基(2-吡啶基氧基)乙酸酯 | 90972-27-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 乙基(2-吡啶基氧基)乙酸酯
• 英文名称: ethyl 2-(pyridin-2-yloxy)acetate
• 英文别名: ethyl 2-pyridin-2-yloxyacetate
• CAS: 90972-27-3
• 化学式: C₉H₁₁NO₃
• mdl: MFCD11226237
• 分子量: 181.191
• InChiKey: OVKQSNSEARBPSV-UHFFFAOYSA-N

物化性质

• 熔点：
  68-69 °C(Solv: chloroform (67-66-3))
• 沸点：
  249.9±15.0 °C(Predicted)
• 密度：
  1.134±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  乙基(2-吡啶基氧基)乙酸酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 10.0h， 生成 (pyridin-2-yloxy)acetic acid (2-hydroxy-4-methoxybenzylidene)hydrazone
  参考文献：
  名称：

  Design and synthesis of conjugated azo-hydrazone analogues using nano BF3·SiO2 targeting ROS homeostasis in oncogenic and vascular progression

  摘要：

  Disrupted redox balance is implicated in multiple pathologies including malignant progression and tumor angiogenesis. In this investigation, we report the design and development of novel and effective ROS detoxifying azo-hydrazone molecules targeting malignant pathologies and neoangiogenesis. A series of azo-derivatives conjugated to hydrazones moieties (9a-j) were synthesized using Nano BF3 center dot SiO2. The compounds (9a-j) were screened for in-vitro antioxidant and lipid peroxidation inhibitory activity. Among the series 9a-j, compound 9f potently quenched biologically relevant radicals such as superoxide and hydrogen peroxide which emerged as the lead ROS detoxifying molecules. Compound 9f potently inhibited the proliferative capability of Daltons Lymphoma Ascites (DLA) tumor cells in-vivo in dose dependent manner. Regressed tumor progression was correlated with pronounced endogenous antioxidant enzyme superoxide dismutase and catalase in-vivo. Also, ROS levels were severely suppressed in 9f treated mice as assessed by lapsed lipid peroxidation. Altered enzymic and ROS levels in-vivo by 9f were implicated in suppressed VEGF secretion leading to regressed tumor neo-vasculature and tumor growth. Considering together, it is evident that the synthetic azo-hydrazone analogue 9f with potent ROS scavenging efficacy inhibits tumor progression and neo-angiogenesis.

  DOI：

  10.1016/j.biopha.2017.08.076
• 作为产物：
  描述：

  2-溴吡啶 、 2-羟基乙酸乙酯钠盐 生成 乙基(2-吡啶基氧基)乙酸酯
  参考文献：
  名称：

  SYNTHESIS OF SOME NEW 2-ARYLOXY AND 2-ALKYLOXY PYRIDINES

  摘要：

  DOI：

  10.1021/jo01157a010

文献信息

• [EN] QUINOLINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE QUINOLINONE
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2012119978A1

  公开（公告）日：2012-09-13

  The present invention relates to compounds of the formula (I), salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds as activators of AMPK.

  本发明涉及式(I)的化合物，其盐，含有它们的药物组合物以及它们在医学上的应用。具体而言，本发明涉及化合物作为AMPK的激活剂。
• Synthesis and biological efficacy of novel piperazine analogues bearing quinoline and pyridine moieties
  作者：M. Al-Ghorbani、N. D. Rekha、V. Lakshmi Ranganatha、T. Prashanth、T. Veerabasappagowda、S. A. Khanum

  DOI：10.1134/s1068162015040020

  日期：2015.9

  A series of novel piperazine analogues bearing quinolin-8-yloxy-butan-1-ones/pyridin-2-yloxyethanones were synthesized by a simple and convenient approach based on various substituted piperazine incorporating quinoline and pyridine moieties. The analogues were evaluated for in vitro antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferrous ion radical scavenging activities and anti-inflammatory

  一系列带有喹啉-8-yloxy-butan-1-ones/pyridin-2-yloxyethanones 的新型哌嗪类似物是通过一种简单方便的方法合成的，该方法基于各种结合喹啉和吡啶部分的取代哌嗪。通过抑制罗氏蝰蛇毒液 (PLA2) 和胃 K+/H+-ATPase 活性，评估了类似物对 2,2-二苯基-1-苦基肼 (DPPH) 和亚铁离子自由基清除活性和抗炎活性的体外抗氧化活性. 大多数标题化合物表现出有希望的活性。发现具有苯基和硝基苯基的哌嗪类似物具有最佳的抗氧化和 PLA2 抑制活性，而苯基哌嗪上的甲氧基表明对 H+/K+-ATPase 具有选择性。
• 一类1,3,4-噁二唑硫醚类化合物及其制备方法和应用
  申请人：贵州大学

  公开号：CN109535144A

  公开（公告）日：2019-03-29

  本发明涉及一类1,3,4‑噁二唑硫醚类化合物及其制备方法和应用。该化合物具有如通式(Ⅰ)所示的结构：该化合物对致病病原细菌和真菌具有较好的抑制作用，针对如水稻白叶枯病菌、烟草青枯病菌、黄瓜白叶枯病菌、魔芋白叶枯病菌、柑桔溃疡病菌、葡萄溃疡病菌、番茄溃疡病菌、猕猴桃溃疡病菌、苹果溃疡病菌、黄瓜灰霉病菌、辣椒枯萎病菌、油菜菌核病菌、小麦赤霉病菌、马铃薯晚疫病菌、蓝莓根腐病菌等均具有较好的抑制效果。
• A Rhodium(II) Catalytic Approach to the Synthesis of Ethers of a Minor Component in a Tautomeric Set
  作者：Jakob Busch-Petersen、E. J. Corey

  DOI：10.1021/ol005964+

  日期：2000.6.1

  [equation--see text] The Rh(II)-catalyzed reaction of diazoacetic esters with various carbonyl compounds is an effective method for the synthesis of acetic ester ethers of the corresponding enol forms.

  [等式-见正文]重氮乙酸酯与各种羰基化合物的Rh（II）催化反应是合成相应烯醇形式的乙酸酯醚的有效方法。
• Synthesis, structure analysis, DFT calculations and energy frameworks of new coumarin appended oxadiazoles, to regress ascites malignancy by targeting VEGF mediated angiogenesis
  作者：Mahima Jyothi、Banumathi、Zabiulla、Ankith Sherapura、Hussien Ahmed Khamees、B.T. Prabhakar、Shaukath Ara Khanum

  DOI：10.1016/j.molstruc.2021.132173

  日期：2022.3

  HNMR and 13CNMR data were also computed and compared to the experiment data. Besides, frontier molecular orbitals (FMOs) through the investigation of highest occupied molecular orbitals (HOMO) and the lowest- unoccupied molecular orbitals (LUMO). The lowermost concentration of electron density on LUMO level compared to the HOMO level, as well as lesser energy gap value denote the ease of electrons transportation

  腹水恶性肿瘤是发病率的常见原因，并且在许多癌症中存在严重的管理问题。血管生成通过血管内皮生长因子 (VEGF) 在腹水肿瘤的预后中起主要作用。抑制VEGF是腹水肿瘤消退的关键策略之一。该研究的目的是合成一类新型 VEGF 抑制剂，用于治疗腹水肿瘤恶性肿瘤。作为一种方法，在多步骤过程中合成了一系列新的 1, 3, 4-恶二唑衍生物，其中包含香豆素-3-取代的芳基和杂芳基部分 ( 7a-l )。这些化合物的结构通过 IR、1 H、13C、核磁共振、质谱和元素分析。新合成的分子通过 MTT 和台盼蓝试验针对 ACHN、A375、SIHA、Skov3 和 EAC 等多种细胞系进行细胞筛选，鉴定出IC 50 -9 µM 的化合物 ( 7k )为铅生物活性分子。此外，VEGF 诱导的非致瘤性 CAM 和 RAT 角膜试验揭示了化合物 ( 7k ) 的血管预防功效。在体外研究中证明了VEGF的表达和相对