(E)-3-(2-methoxyphenyl)-1-(piperidin-1-yl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(2-methoxyphenyl)-1-(piperidin-1-yl)prop-2-en-1-one
• 英文别名: 1-(2-methoxy-cinnamoyl)-piperidine；(E)-3-(2-methoxyphenyl)-1-piperidin-1-ylprop-2-en-1-one
• 化学式: C₁₅H₁₉NO₂
• 分子量: 245.321
• InChiKey: ABJWBHHWQDWHJS-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  邻甲氧基苯甲醛 在 哌啶 、 吡啶 、 三乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 (E)-3-(2-methoxyphenyl)-1-(piperidin-1-yl)prop-2-en-1-one
  参考文献：
  名称：

  Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/keap1 pathway

  摘要：

  Parkinson's disease (PD) is a slowly progressive and complex neurodegenerative disorder. Up to date, there are no approved drugs that could slow or reverse the neurodegenerative process of PD. Here, we reported the synthesis of series of piperine analogues and the evaluation of their neuroprotective effects against hydrogen peroxide (H2O2) induced damage in the neuron-like PC12 cells. Among these analogues, 3b exhibited the most potent protection effect and its underlying mechanism was further investigated. Further results indicated that the ROS scavenging and cytoprotection effect of 3b might be related to the Nrf2 activation and upregulation of related phase II antioxidant enzymes, such as HO-1 and NQO1. In in vivo study, oral administration (100 mg/kg) of 3b significantly attenuated PD-associated behavioral deficits in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD and protected tyrosine hydroxylase-immunopositive dopaminergic neurons. Our results provided evidence that 3b might be a promising candidate for Parkinson's disease treatment. (C) 2020 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2020.112385

文献信息

• Treatment of skin conditions
  申请人：BTG International Limited

  公开号：US20020168369A1

  公开（公告）日：2002-11-14

  The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also for treating skin cancer. The piperine and analogues or derivatives thereof may also be used to cosmetically promote or enhance the natural coloration of the skin.

  本发明提供了辣椒碱及其类似物或衍生物，用于治疗可通过刺激黑色素细胞增殖来治疗的皮肤状况，如白癜风，并且用于治疗皮肤癌。辣椒碱及其类似物或衍生物也可用于美容促进或增强皮肤的自然着色。
• 熱塩基発生剤、硬化性組成物、および、硬化物
  申请人：太陽ホールディングス株式会社

  公开号：JP2019189539A

  公开（公告）日：2019-10-31

  【課題】光安定性および室温付近での安定性が高く、かつ、加熱後には熱硬化性化合物の硬化触媒として十分に機能する熱塩基発生剤、該熱塩基発生剤を含む硬化性組成物および該硬化性組成物の硬化物を提供する。【解決手段】下記一般式（１）で表されることを特徴とする桂皮酸アミド型熱塩基発生剤等である。（一般式（１）中、Ｒ１およびＲ２は隣接する窒素原子と共に、芳香性を有する複素環を形成し、Ｒ３およびＲ４は、それぞれ独立に、水素原子、ハロゲン原子、または一価の有機基であり、Ｒ５〜Ｒ９は、それぞれ独立に、水酸基および加熱でフェノール性水酸基を生成する基以外の基または原子である。）【選択図】なし

  这是一种具有高光稳定性和室温附近稳定性的热碱发生剂，且在加热后作为热固化化合物的固化催化剂充分发挥功能，提供包含该热碱发生剂的固化性组合物以及该固化性组合物的固化物。这种热碱发生剂是一种桂皮酸酰胺型热碱发生剂，其特征在于由下述通式（1）表示。（在通式（1）中，R1和R2与相邻的氮原子一起形成含有芳香性的复杂环，R3和R4分别独立地是氢原子、卤素原子或一价有机基，R5至R9分别独立地是除生成羟基和加热后生成酚羟基的基团或原子之外的基团或原子。）【选择图】无
• Use of piperine and derivatives thereof for the therapy of neurological conditions
  申请人：Sygnis Bioscience GmbH & Co. KG

  公开号：EP2011495A1

  公开（公告）日：2009-01-07

  The present invention relates to the use of piperine and derivatives thereof for the preparation of a pharmaceutical composition for treating and/or preventing a neuronal condition where there is a need of neuroprotection and/or neuroregeneration. The invention furthermore relates to the use of piperine and derivatives thereof for the in vitro differentiation of neuronal stem cells and the use of such pre-treated cells for stem cell therapy von neurological conditions.

  本发明涉及使用胡椒碱及其衍生物制备药物组合物，用于治疗和/或预防需要神经保护和/或神经再生的神经元疾病。本发明还涉及将胡椒碱及其衍生物用于神经元干细胞的体外分化，以及将这种预处理细胞用于干细胞治疗神经系统疾病。
• NEGATIVE-TYPE PHOTOSENSITIVE RESIN COMPOSITION, PATTERN FORMING METHOD, CURED FILM, INSULATING FILM, COLOR FILTER, AND DISPLAY DEVICE
  申请人：Tokyo Ohka Kogyo Co., Ltd.

  公开号：EP2725423A1

  公开（公告）日：2014-04-30

  Provided are: a negative-type photosensitive resin composition capable of forming a pattern having favorable adhesiveness at a low light exposure; a pattern forming method using the negative-type photosensitive resin composition; a cured film, an insulating film, and a color filter formed using the negative-type photosensitive resin composition; and a display device provided with the cured film, insulating film, or color filter. The negative-type photosensitive resin composition according to the present invention contains a compound represented by the following formula (1). In the formula, R1 and R2 each independently indicate a hydrogen atom or an organic group, but at least one indicates an organic group. R1 and R2 may be bonded to form a ring structure and may contain a hetero atom bond. R3 indicates a single bond or an organic group. R4 to R9 each independently indicate a hydrogen atom, an organic group, etc., but R6 and R7 are never hydroxyl groups. R10 indicates a hydrogen atom or an organic group.

  本发明提供了：一种负型感光树脂组合物，该组合物能够在低光曝光下形成具有良好粘合性的图案；一种使用该负型感光树脂组合物的图案形成方法；一种使用该负型感光树脂组合物形成的固化薄膜、绝缘薄膜和彩色滤光片；以及一种装有该固化薄膜、绝缘薄膜或彩色滤光片的显示装置。根据本发明的负型感光树脂组合物含有下式（1）表示的化合物。式中，R1 和 R2 各自独立地表示氢原子或有机基团，但至少有一个表示有机基团。R1 和 R2 可以键合形成环状结构，也可以含有杂原子键。R3 表示单键或有机基团。R4 至 R9 各自独立地表示氢原子、有机基团等，但 R6 和 R7 绝不是羟基。R10 表示氢原子或有机基团。
• NOVEL COMPOUND
  申请人：Tokyo Ohka Kogyo Co., Ltd.

  公开号：EP2725011A1

  公开（公告）日：2014-04-30

  Provided is a novel compound suitable for obtaining a negative-type photosensitive resin composition capable of forming a pattern having favorable adhesiveness at a low light exposure. The compound according to the present invention is represented by the following formula (1). In the formula, R1 and R2 each independently indicate a hydrogen atom or an organic group, but at least one indicates an organic group. R1 and R2 may be bonded to form a ring structure and may contain a hetero atom bond. R3 indicates a single bond or an organic group. R4 to R9 each independently indicate a hydrogen atom, an organic group, etc., but R6 and R7 are never hydroxyl groups. R10 indicates a hydrogen atom or an organic group.

  本发明提供了一种新型化合物，该化合物适用于获得底片型感光树脂组合物，该组合物能够在低光照条件下形成具有良好粘合性的图案。根据本发明的化合物由下式（1）表示。式中，R1 和 R2 各自独立地表示氢原子或有机基团，但至少有一个表示有机基团。R1 和 R2 可以键合形成环状结构，也可以含有杂原子键。R3 表示单键或有机基团。R4 至 R9 各自独立地表示氢原子、有机基团等，但 R6 和 R7 绝不是羟基。R10 表示氢原子或有机基团。