4-(1,2-Dithiolane-3-yl)butane | 114113-94-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二硫杂环戊烷
• 英文名称: 4-(1,2-Dithiolane-3-yl)butane
• 英文别名: 3-Butyldithiolane
• CAS: 114113-94-9
• 化学式: C₇H₁₄S₂
• 分子量: 162.32
• InChiKey: MCFFCORKYUUNFR-UHFFFAOYSA-N

物化性质

• 沸点：
  221.5±7.0 °C(Predicted)
• 密度：
  1.025±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-hydroxysulfanylheptane-1-thiol 生成 4-(1,2-Dithiolane-3-yl)butane
  参考文献：
  名称：

  MENON, RANI B.;KUMAR, M. ANIL;RAVINDRANATHAN, T., TETRAHEDRON LETT., 28,(1987) N 44, 5313-5314

  摘要：

  DOI：

文献信息

• Stereospecific synthesis of α-lipoic acid
  作者：Rani B. Menon、M.Anil Kumar、T. Ravindranathan

  DOI：10.1016/s0040-4039(00)96717-0

  日期：1987.1

  Short and highly stereospecific synthesis of (S)-(-)- and (R)-(+)-α-lipoic acid using menthone as a recyclable chiral auxiliary is presented.

  提出了使用薄荷酮作为可回收的手性助剂的（S）-（-）-和（R）-（+）-α-硫辛酸的短而高度立体定向的合成。
• [EN] COMPOSITION COMPRISING PAEONIFLORIN OR ALBIFLORIN ANALOGUE, METHOD OF PREPARATION THEREOF<br/>[FR] COMPOSITION COMPRENANT DE LA PAEONIFLORINE OU UN ANALOGUE D'ALBIFLORINE, SON PROCÉDÉ DE PRÉPARATION
  申请人：OREAL

  公开号：WO2018053706A1

  公开（公告）日：2018-03-29

  A composition comprises a compound of formula (I) and at least one cosmetically acceptable carrier. It can be used for preventing or decreasing skin pigmentation and /or lightening skin tone.

  一种组合物包括化合物的化学式(I)和至少一种化妆品可接受的载体。它可用于预防或减少皮肤色素沉着和/或淡化肤色。
• [EN] ANTIOXIDANT NANOSPHERE COMPRISING [1,2]-DITHIOLANE MOIETIES<br/>[FR] NANOSPHÈRE ANTIOXYDANTE COMPRENANT DES GROUPEMENTS [1,2]-DITHIOLANE
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2009086547A1

  公开（公告）日：2009-07-09

  The present invention is directed to multiple a-lipoic acid-containing hydrophobic compounds (mALAs) capable of acting as scavengers of free radicals, metals and reactive oxygen species (ROS). Methods of synthesizing novel antioxidant mALAs, spontaneous emulsification or nanoprecipitaion thereof to produce antioxidant nanospheres and their use in preventing or treating diseases or conditions caused by oxidative stress and other free radical mediated conditions are also described. Another aspect of this invention is the use of these antioxidant nanospheres for the preparation of antioxidant particulate delivery system of therapeutic agents.

  本发明涉及多种含有α-硫辛酸的疏水化合物（mALAs），其能够作为自由基、金属和反应性氧化物（ROS）的清除剂。还描述了合成新型抗氧化剂mALAs的方法，以及自发乳化或纳米沉淀制备抗氧化纳米球的方法，并将其用于预防或治疗由氧化应激和其他自由基介导的疾病或病症。本发明的另一个方面是利用这些抗氧化纳米球制备治疗剂的抗氧化颗粒递送系统。
• [EN] COMPOUNDS AND METHODS FOR THE TREATMENT OF OCULAR DISORDERS<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR LE TRAITEMENT DE TROUBLES OCULAIRES
  申请人：AZURA OPHTHALMICS LTD

  公开号：WO2020212760A2

  公开（公告）日：2020-10-22

  Described herein are compositions and methods for the treatment of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory/ infections disease of the anterior surface of the eye. Said compositions and methods comprise keratolytic conjugate which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eye, ocular surface or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.
• MENON, RANI B.;KUMAR, M. ANIL;RAVINDRANATHAN, T., TETRAHEDRON LETT., 28,(1987) N 44, 5313-5314
  作者：MENON, RANI B.、KUMAR, M. ANIL、RAVINDRANATHAN, T.

  DOI：——

  日期：——