(4-isopropyl-phenyl)-malonic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (4-isopropyl-phenyl)-malonic acid
• 英文别名: (4-Isopropyl-phenyl)-malonsaeure；2-(4-Propan-2-ylphenyl)propanedioic acid
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: KWXORCAJIYUTLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  magnesium,1-methanidyl-4-propan-2-ylbenzene,chloride 、 methylammonium carbonate 生成 (4-isopropyl-phenyl)-malonic acid
  参考文献：
  名称：

  Ivanoff; Pchenitchny, Bulletin de la Societe Chimique de France, 1934, vol. <5> 1, p. 223,229

  摘要：

  DOI：

文献信息

• Study of the family of a patient with male-limited precocious puberty (MPP) due to T1193C transition in exon 11 of LH receptor gene
  作者：M. Ignacak、J. Starzyk、H. Dziatkowiak、W. H. Trzeciak

  DOI：10.1007/bf03344001

  日期：2002.3

  Molecular diagnostics of the LHR gene was conducted in a 5-year-old boy with clinical symptoms and hormonal profile typical of precocious puberty. His parents and 4 sisters were also diagnosed. Single-strand conformation polymorphism analysis under temperature gradient conditions (Multitemperature SSCP) of 3 overlapping fragments of exon 11 of LHR gene revealed a mutation in the fragment spanning nucleotides 1072 to 1804. This mutation was found in the patient, in his mother and in his 4 sisters, and was confirmed by digestion with the use of restriction enzyme Bbr Cl. Direct sequencing revealed a heterozygous T1193C transition in the DNA fragment of the patient and in one of the alleles of his mother's and sister's DNA. This mutation causes Met398Thr substitution in the second transmembrane helix and results in a constitutive activation of LH receptor. This is the second identical mutation detected in Poland and one of the 7 identified so far in the world population.
• US5270313A
  申请人：——

  公开号：US5270313A

  公开（公告）日：1993-12-14
• Ivanoff; Pchenitchny, Bulletin de la Societe Chimique de France, 1934, vol. <5> 1, p. 223,229
  作者：Ivanoff、Pchenitchny

  DOI：——

  日期：——