camphorsultam, acetylated

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: camphorsultam, acetylated
• 英文别名: (2R)-N-acetylbomane-10,2-sultam；N-Acetyl-(2R)-bornane-10,2-sultam；1-(10,10-dimethyl-3,3-dioxo-3λ6-thia-4-azatricyclo[5.2.1.01,5]decan-4-yl)ethanone
• 化学式: C₁₂H₁₉NO₃S
• 分子量: 257.354
• InChiKey: FECARJHVTMSYSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  camphorsultam, acetylated 在 水 、 三乙胺 、 lithium bromide 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以90%的产率得到camphorsultam
  参考文献：
  名称：

  A mild hydrolysis of esters mediated by lithium salts

  摘要：

  When treated with amine bases such as triethylamine and various lithium salts in wet solvents, esters are efficiently hydrolyzed to the corresponding acids in good yields. Esters incorporating an alpha- or beta-heteroatom with respect to the ester carbonyl group are hydrolyzed rapidly even at room temperature. To further demonstrate the usefulness of this method, one example is provided where hydrolysis of acetylated camphorsultam is mediated by LiBr. (c) 2007 Elsevier Ltd. All riehts reserved.

  DOI：

  10.1016/j.tetlet.2007.02.029

文献信息

• Intermediates for the synthesis of epothilones and methods for their preparation
  申请人：Novartis AG

  公开号：US06350878B1

  公开（公告）日：2002-02-26

  The invention relates to a method of synthesis for a compound of formula (I), wherein R is a heterocyclyl moiety and X1, X2, X3 and X4 are, independently of each other, protecting groups, which is appropriate for the synthesis of epothilone B and desoxyepothione B.

  该发明涉及一种合成方法，用于合成化合物的公式（I），其中R是杂环基团，X1、X2、X3和X4是独立的保护基团，适用于合成紫杉醇B和去氧紫杉醇B。
• [EN] PROCESS FOR IXABEPILONE, AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉ DE FABRICATION D'IXABÉPILONE, ET PRODUITS INTERMÉDIAIRES DE CELUI-CI
  申请人：SCINOPHARM TAIWAN LTD

  公开号：WO2014136099A1

  公开（公告）日：2014-09-12

  The present invention relates to a novel process of making ixabepilone, ixabepilone derivatives and analogues, and intermediates thereof.

  本发明涉及一种制备伊西贝铂、伊西贝铂衍生物和类似物及其中间体的新工艺。
• PEPTIDOMIMETIC PROTEASE INHIBITORS
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20140294763A1

  公开（公告）日：2014-10-02

  The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

  本发明涉及肽类似物化合物，可用作蛋白酶抑制剂，特别是作为丝氨酸蛋白酶抑制剂，更特别是作为丙型肝炎NS3蛋白酶抑制剂；其中间体；它们的制备，包括新的立体选择性过程到中间体。该发明还涉及制药组合物和使用该化合物抑制HCV蛋白酶或治疗患有HCV感染或与感染相关的生理状况的患者的方法。还提供了制药组合物，包括除一个或多个HCV丝氨酸蛋白酶抑制剂外，还有一个或多个表现出抗HCV活性的干扰素和/或一个或多个具有抗HCV活性的化合物和药学上可接受的载体，并使用该组合物治疗或预防患者的HCV感染的方法。本发明还涉及用于治疗或预防患者HCV感染的套件或药物包装。
• PROCESS FOR IXABEPILONE, AND INTERMEDIATES THEREOF
  申请人：ScinoPharm Taiwan, Ltd.

  公开号：EP2964645B1

  公开（公告）日：2018-07-11
• PROCESS FOR THE PREPARATION OF EPOTHILONES
  申请人：Chen Yue

  公开号：US20080319211A1

  公开（公告）日：2008-12-25

  Intermediates in the preparation of epothilones and epothilone analogs are provided along with synthetic methods useful in the synthesis of epothilone compounds.