2-乙氧基噻吩 | 36448-24-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-乙氧基噻吩
• 英文名称: 2-Ethoxythiophene
• 英文别名: 2-ethoxy-thiophene；2-Aethoxy-thiophen
• CAS: 36448-24-5
• 化学式: C₆H₈OS
• 分子量: 128.195
• InChiKey: VYDVLDNLTSOBLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-乙氧基噻吩 在 N-溴代丁二酰亚胺(NBS) 、 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 7.0h， 生成 1,2-bis(2-ethoxy-5-phenyl-3-thienyl)perfluorocyclopentene
  参考文献：
  名称：

  Dithienylethenes with a Novel Photochromic Performance

  摘要：

  Dithienylethenes with low decoloration quantum yields and thermal reversibility at high temperature above 100degreesC were prepared. Introduction of bulky alkoxy substituents at 2- and 2'-positions of the thiophene rings strongly suppressed the cycloreversion quantum yields. The quantum yields were lower than 10(-3), and the photogenerated color remained stable enough under room light. On the other hand, the bulky alkoxy substituent decreased the thermal stability of the colored closed-ring isomers at high temperature. The color of the dithienylethene with cyclohexyloxy substituents faded out in less than 1 min at 160degreesC.

  DOI：

  10.1021/jo020114o
• 作为产物：
  描述：

  2-碘噻吩 、 sodium ethanolate 在 铜 作用下， 生成 2-乙氧基噻吩
  参考文献：
  名称：

  Profft, Justus Liebigs Annalen der Chemie, 1959, vol. 622, p. 196,198

  摘要：

  DOI：

文献信息

• Process for production of amines
  申请人：Terada Masahiro

  公开号：US20070142639A1

  公开（公告）日：2007-06-21

  A process for producing an amine which is characterized by reacting an imine with a nucleophilic compound (except a trialkylsilyl vinyl ether) in the presence of a phosphoric acid derivative represented by the formula (1): wherein A 1 represents a spacer; X 1 and X 2 represent each independently a divalent nonmetal atom or a divalent nonmetal atomic group; and Y 1 is oxygen or sulfur. The invention provides a process by which amines (particularly optically active amines) useful as intermediates of medicines, agricultural chemicals, or the like can be produced without special post-treatment in high yield at high optical purity; and phosphoric acid derivatives (particularly optically active phosphoric acid derivatives) useful in the production of the amines.

  一种生产胺的方法，其特征在于在式（1）所代表的磷酸衍生物存在下，将亚胺与一种亲核化合物（三烷基硅基乙烯醚除外）反应： 其中A1代表一个间隔物；X1和X2分别独立表示二价非金属原子或二价非金属原子团；Y1为氧或硫。该发明提供了一种方法，通过该方法，可以在高光学纯度下高产率地生产用作药品、农药等中间体的胺（特别是光学活性胺），而无需进行特殊的后处理；以及用于生产这些胺的磷酸衍生物（特别是光学活性磷酸衍生物）。
• [EN] ACRYLAMIDE COMPOUNDS<br/>[FR] COMPOSÉS D'ACRYLAMIDE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2021117733A1

  公开（公告）日：2021-06-17

  Provided is an acrylamide compound, which is useful for the promotion of platelet production from platelet progenitor cells such as megakaryocytes in vitro and represented by general formula [I]:wherein each symbol is as defined in the description.

  提供的是一种丙烯酰胺化合物，可用于促进体外血小板祖细胞（如巨核细胞）产生血小板的作用，其通用结构式为[I]，其中每个符号如描述中所定义。
• Antitumor compositions and methods of treatment
  申请人：Eli Lilly and Company

  公开号：US05302724A1

  公开（公告）日：1994-04-12

  This invention provides certain sulfonamide compounds, formulations and method of use of certain sulfonamide compounds in treating susceptible neoplasms.

  这项发明提供了某些磺胺酰胺化合物、配方和使用某些磺胺酰胺化合物治疗易感肿瘤的方法。
• Intermolecular carbenoid insertions: Reactions of 2-substituted thiophenes with ethyl diazoacetate in the presence of rhodium (II) acetate
  作者：Geoffrey K. Tranmer、Alfredo Capretta

  DOI：10.1016/s0040-4020(98)01018-7

  日期：1998.12

  The reactions of ethyl diazoacetate with a series of 2-substituted thiophenes in the presence of catalytic rhodium (II) acetate were examined. In the cases of 2-methylthiophene and 2-(trimethylsilyl)thiophene, cyclopropane and thiopyran products predominated while thiophene-2-thiol and 2-(methylthio)thiophene gave rise to thiopyrans and ethyl 2-(2-thienylsulfanyl)acetate. No reaction was apparent when

  研究了重氮乙酸乙酯在一系列催化铑（II）存在下与2-取代噻吩的反应。在2-甲基噻吩和2-（三甲基甲硅烷基）噻吩的情况下，环丙烷和噻吩产物占主导，而噻吩-2-硫醇和2-（甲基硫代）噻吩产生噻喃和2-（2-噻吩基硫烷基）乙酸乙酯。当使用2-吡咯烷基噻吩时，没有反应是明显的。然而，2-烷氧基噻吩可以产生一系列的6-烷氧基-6-thioxo-2，4-己二酸乙酯。讨论了机械含义。
• Copper(I) halide catalysed synthesis of alkyl aryl and alkyl heteroaryl ethers
  作者：Menno A. Keegstra、Theo H.A. Peters、Lambert Brandsma

  DOI：10.1016/s0040-4020(01)88501-x

  日期：1992.1

  A number of alkyl aryl and alkyl heteroaryl ethers have been prepared from (hetero) aryl halides (mainly bromides) and sodium alkoxides, using copper(I)bromide as a catalyst. The influence of the main solvent, the halogen atom, reaction temperature and the presence of oxygen upon the rate and selectivity has been studied. Furthermore the decomposition of the catalyst and the reduction of the aryl halide

  使用溴化铜（I），由（杂）芳基卤化物（主要是溴化物）和醇钠制备了许多烷基芳基和烷基杂芳基醚。研究了主要溶剂，卤素原子，反应温度和氧的存在对反应速率和选择性的影响。此外，还研究了催化剂的分解和芳基卤化物的还原。