7-羟基-6-甲氧基-3,4-二氢色烯-2-酮 | 90843-91-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 3,4-二氢香豆素
• 中文名称: 7-羟基-6-甲氧基-3,4-二氢色烯-2-酮
• 英文名称: scopoletin
• 英文别名: 7-hydroxy-6-methoxy chroman-2-one；7-Hydroxy-6-methoxy-3,4-dihydro-2H-1-benzopyran-2-one；7-hydroxy-6-methoxy-3,4-dihydrochromen-2-one
• CAS: 90843-91-7
• 化学式: C₁₀H₁₀O₄
• 分子量: 194.187
• InChiKey: XEHFSYYAGCUKEN-UHFFFAOYSA-N

物化性质

• 沸点：
  391.1±42.0 °C(Predicted)
• 密度：
  1.327±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-羟基-6-甲氧基-3,4-二氢色烯-2-酮 在 二异丁基氢化铝 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.5h， 以88%的产率得到6-methoxychroman-2,7-diol
  参考文献：
  名称：

  Synthesis of 6-methoxy-4H-1-benzopyran-7-ol, a character donating component of the fragrance of Wisteria sinensis

  摘要：

  6-Methoxy-4H-1-benzopyran-7-ol 7, a major impact flavor compound of Wisteria sinensis has been synthesized from 2,4,5-trimethoxybenzaldehyde 1 via scopoletin 3. The synthetic sequence comprised (i) bisdemethylation of 2,4,5-timethoxybenzaldehyde 1, (ii) Wittig reaction with ethoxycarbonylmethylenetriphenylphosphorane, (iii) hydrogenation on palladium/carbon in glacial acetic acid, (iv) DIBAL-H reduction of the intermediate lactone and (v) dehydration of the lactol with anhydrous oxalic acid. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00081-9
• 作为产物：
  描述：

  东莨菪内酯 在 palladium on activated charcoal 氢气 作用下， 以 溶剂黄146 为溶剂， 50.0 ℃ 、340.0 kPa 条件下， 反应 17.0h， 以94%的产率得到7-羟基-6-甲氧基-3,4-二氢色烯-2-酮
  参考文献：
  名称：

  Synthesis of 6-methoxy-4H-1-benzopyran-7-ol, a character donating component of the fragrance of Wisteria sinensis

  摘要：

  6-Methoxy-4H-1-benzopyran-7-ol 7, a major impact flavor compound of Wisteria sinensis has been synthesized from 2,4,5-trimethoxybenzaldehyde 1 via scopoletin 3. The synthetic sequence comprised (i) bisdemethylation of 2,4,5-timethoxybenzaldehyde 1, (ii) Wittig reaction with ethoxycarbonylmethylenetriphenylphosphorane, (iii) hydrogenation on palladium/carbon in glacial acetic acid, (iv) DIBAL-H reduction of the intermediate lactone and (v) dehydration of the lactol with anhydrous oxalic acid. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00081-9

文献信息

• Structural features controlling cation-radical line-broadening in the 1H-NMR spectra of phenol derivatives in acid media
  作者：Isam K.L. Al-Khayat、Francis M. Dean、Rajender S. Varma

  DOI：10.1016/s0040-4020(01)86907-6

  日期：1987.1

  of cation radicals from 2,3,4,7-8,9-hexahydro-2,2,5.7,7, 10-hexamethylbenzo[1,2-b; 4,5-b']dipyran (1) and the isomeric benzo[1,2-b; 4,3-b']dipyran (3) have been characterised. The production of cation radical from (1) in acid media is limited by acid concentration for weak acids and also by the presence of oxygen for strong acids. The cation radical species (Ar+) is considered to originate from substrate

  来自2,3,4,7-8,9-六氢-2,2,5.7,7，10-六甲基苯并[1,2-b]的阳离子的六氯锑酸酯; 4,5-b']双吡喃（1）和异构体苯并[1,2-b; 已经表征了4，3-b′]双吡喃（3）。在弱酸中，由（1）在酸性介质中产生的阳离子自由基受到酸浓度的限制，而对于强酸，氧的存在也受到限制。阳离子自由基种类（Ar +）被认为是通过质子化从底物（Ar）产生，然后从中性底物（Ar）进行电子转移; 仅当这种转移在结构上有利时，酚衍生物的H-nmr谱线才会展宽。立体化学作用极大地降低了对酸的敏感性，并且在苯-1,2,4-三醇的衍生物中，在一个环中存在两个氧原子是极其不利的。由于酚阳离子自由基是相当强的酸，因此最好通过醚（通过氧化剂或循环伏安法）研究它们在弱酸介质中的行为。
• Moore, Journal of the Chemical Society, 1911, vol. 99, p. 1044
  作者：Moore

  DOI：——

  日期：——
• Extracts of Curcuma and Methods of Use Thereof
  申请人：Alberte Randall S.

  公开号：US20100098788A1

  公开（公告）日：2010-04-22

  The present invention relates in part to turmeric extracts that are useful for treating or preventing neurodegenerative disorders. Another aspect of the invention relates in part to turmeric extracts that are useful for treating or preventing inflammatory disorders. In some embodiments, the extracts comprise at least one compound selected from the group consisting of 25 to 500 μg bamosamine, 25 to 750 μg echinaxanthol, 100 to 3,000 μg bisdemethoxycurcumin, 50 to 500 μg daphniyunnine E and 500 to 75,000 μg curcumin per 100 mg of extract. Another aspect of the invention relates to pharmaceutical compositions comprising the aforementioned extracts. Another aspect of the invention relates to methods of treating or preventing neurodegenerative disorders comprising administering to a subject in need thereof an effective amount of the aforementioned extracts or compositions. Another aspect of the invention relates to methods of making the aforementioned extracts.
• [EN] EXTRACTS OF CURCUMA AND METHODS OF USE THEREOF<br/>[FR] EXTRAITS DE CURCUMA ET LEURS PROCÉDÉS D'UTILISATION
  申请人：HERBALSCIENCE GROUP LLC

  公开号：WO2010045577A2

  公开（公告）日：2010-04-22

  The present invention relates in part to turmeric extracts that are useful for treating or preventing neurodegenerative disorders. Another aspect of the invention relates in part to turmeric extracts that are useful for treating or preventing inflammatory disorders. In some embodiments, the extracts comprise at least one compound selected from the group consisting of 25 to 500 μg bamosamine, 25 to 750 μg echinaxanthol, 100 to 3,000 μg bisdemethoxycurcumin, 50 to 500 μg daphniyunnine E and 500 to 75,000 μg curcumin per 100 mg of extract. Another aspect of the invention relates to pharmaceutical compositions comprising the aforementioned extracts. Another aspect of the invention relates to methods of treating or preventing neurodegenerative disorders comprising administering to a subject in need thereof an effective amount of the aforementioned extracts or compositions. Another aspect of the invention relates to methods of making the aforementioned extracts.
• Synthesis of 6-methoxy-4H-1-benzopyran-7-ol, a character donating component of the fragrance of Wisteria sinensis
  作者：Jan Demyttenaere、Kris Van Syngel、A Peter Markusse、Stijn Vervisch、Silvia Debenedetti、Norbert De Kimpe

  DOI：10.1016/s0040-4020(02)00081-9

  日期：2002.3

  6-Methoxy-4H-1-benzopyran-7-ol 7, a major impact flavor compound of Wisteria sinensis has been synthesized from 2,4,5-trimethoxybenzaldehyde 1 via scopoletin 3. The synthetic sequence comprised (i) bisdemethylation of 2,4,5-timethoxybenzaldehyde 1, (ii) Wittig reaction with ethoxycarbonylmethylenetriphenylphosphorane, (iii) hydrogenation on palladium/carbon in glacial acetic acid, (iv) DIBAL-H reduction of the intermediate lactone and (v) dehydration of the lactol with anhydrous oxalic acid. (C) 2002 Elsevier Science Ltd. All rights reserved.

表征谱图