5,7-二羟基-4-亚氨基-2-氧代色满 | 91670-99-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 3,4-二氢香豆素
• 中文名称: 5,7-二羟基-4-亚氨基-2-氧代色满
• 英文名称: 5,7-dihydroxy-4-imino-2-oxochroman
• 英文别名: 5,7-dihydroxy-4-iminochromen-2-one
• CAS: 91670-99-4
• 化学式: C₉H₇NO₄
• 分子量: 193.159
• InChiKey: ZTRFLYOPDVZVMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  90.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5,7-二羟基-4-亚氨基-2-氧代色满 在 sodium nitrite 作用下， 以 盐酸 为溶剂， 反应 0.05h， 生成 5,7-dihydroxy-4-imino-8-nitroso-2-oxochroman
  参考文献：
  名称：

  5,7-二羟基-4-亚氨基-2-氧代苯并二甲酰胺分光光度法测定水中的亚硝酸盐。

  摘要：

  DOI：

  10.1021/ac00276a058
• 作为产物：
  描述：

  间苯三酚 、 氰乙酸乙酯 生成 5,7-二羟基-4-亚氨基-2-氧代色满
  参考文献：
  名称：

  ZHANG, ZHENYU;QU, SHUYUAN;LU, XIUHUA, CHEM. REAGENTS, 10,(1988) N 2, 112-114

  摘要：

  DOI：

文献信息

• COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
  申请人：Johansen Lisa M.

  公开号：US20100009970A1

  公开（公告）日：2010-01-14

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

  本发明涉及用于治疗病毒性疾病的组合物、方法和试剂盒。在某些实施方式中，病毒性疾病是由单链RNA病毒、黄病毒科病毒或肝病毒引起的。在特定实施方式中，病毒性疾病是病毒性肝炎（例如甲型肝炎、乙型肝炎、丙型肝炎、丁型肝炎、戊型肝炎），药剂或药剂组合包括舍曲林、舍曲林类似物、UK-416244或UK-416244类似物。还包括用于鉴定可用于治疗病毒性疾病的新化合物的筛选方法。
• Coumarin derivative as antiviral agent, pharmaceutical composition thereof, its preparation and use
  申请人：I-NOVA MEDICINSKA ISTRAZIVANJA D.O.O.

  公开号：US10266545B2

  公开（公告）日：2019-04-23

  The present invention discloses the novel coumarin derivative of formula (1): its synthesis, pharmaceutical composition, preparation and use thereof. The pharmaceutical composition including: (1) the novel coumarin derivative of formula (1) as active pharmaceutical ingredient; and (2) one or more pharmaceutical excipients, required to yield final dosage forms suitable for therapeutic administration. The composition is safe and efficient therapeutic agent for viral diseases including the acquired immunodeficiency syndrome (AIDS).

  本发明公开了式 (1) 的新型香豆素衍生物： 的合成、药物组合物、制备及其用途。该药物组合物包括：(1) 作为活性药物成分的式 (1) 新型香豆素衍生物；(2) 一种或多种药用赋形剂，这些赋形剂需要制成适合治疗用药的最终剂型。该组合物是治疗包括获得性免疫缺陷综合征（艾滋病）在内的病毒性疾病的安全有效的治疗剂。
• Compositions and methods for treatment of viral diseases
  申请人：Johansen Lisa M.

  公开号：US20080161324A1

  公开（公告）日：2008-07-03

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E). Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.
• COUMARIN DERIVATIVE AS ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION THEREOF, ITS PREPARATION AND USE
  申请人：I-NOVA MEDICINSKA ISTRAZIVANJA D.O.O.

  公开号：US20180072752A1

  公开（公告）日：2018-03-15

  The present invention discloses the novel coumarin derivative of formula (1): its synthesis, pharmaceutical composition, preparation and use thereof. The pharmaceutical composition including: (1) the novel coumarin derivative of formula (1) as active pharmaceutical ingredient; and (2) one or more pharmaceutical excipients, required to yield final dosage forms suitable for therapeutic administration. The composition is safe and efficient therapeutic agent for viral diseases including the acquired immunodeficiency syndrome (AIDS).
• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE MALADIES VIRALES
  申请人：COMBINATORX SINGAPORE PRE LTD

  公开号：WO2008033466A2

  公开（公告）日：2008-03-20

  [EN] The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E). Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.
  [FR] La présente invention concerne des compositions, procédés et kits utiles dans le traitement de maladies virales. Dans certains modes de réalisation, la maladie virale est causée par un virus à ARN simple brin, un virus Flaviviridae, ou un virus hépatique. Dans des modes de réalisation particuliers, la maladie virale est l'hépatite virale (par exemple, hépatite A, hépatite B, hépatite C, hépatite D, hépatite E). La présente invention concerne également des procédés de criblage en vue de l'identification de nouveaux composés qui peuvent être utilisés pour traiter une maladie virale.