5-二甲氨基戊胺 | 2683-56-9

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 5-二甲氨基戊胺
• 中文别名: 4-二乙胺基-1-丁醇；S(-)-α-甲基苄胺；(N,N-二乙基)-4-氨基-1-丁醇；4-二乙氨基-1-丁醇
• 英文名称: 4-(N,N-diethylamino)-1-butanol
• 英文别名: 4-(Diethylamino)-1-butanol；4-Diethylamino-butanol-(1)；4-(Diethylamino)butan-1-ol
• CAS: 2683-56-9
• 化学式: C₈H₁₉NO
• 分子量: 145.245
• InChiKey: KHYKXDSWXWVQTA-UHFFFAOYSA-N

物化性质

• 沸点：
  82°C 3mm
• 密度：
  0.9103 g/cm3(Temp: 14 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  CORROSIVE
• 危险品标志：
  C
• 危险类别码：
  R36/37/38
• 危险品运输编号：
  UN 2735
• 海关编码：
  2922199090
• 安全说明：
  S26,S36/37/39
• 储存条件：
  存储条件：2-8°C，密封保存，并保持干燥。

反应信息

• 作为反应物：
  描述：

  5-二甲氨基戊胺 在 氢溴酸 作用下， 生成 4-bromo-(N,N-diethyl)butylamine
  参考文献：
  名称：

  Sen,A.B.; Singh,P.R., Journal of the Indian Chemical Society, 1960, vol. 37, # 4, p. 217 - 222

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(二乙基氨基)丁酸乙酯 在 乙醇 、 sodium 作用下， 生成 5-二甲氨基戊胺
  参考文献：
  名称：

  Magidson; Strukow, Zhurnal Obshchei Khimii, 1934, vol. 4, p. 253,266

  摘要：

  DOI：

文献信息

• Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease
  作者：Li Luo、Qing Song、Yan Li、Zhongcheng Cao、Xiaoming Qiang、Zhenghuai Tan、Yong Deng

  DOI：10.1016/j.bmc.2020.115400

  日期：2020.4

  of phthalide alkyl tertiary amine derivatives were designed, synthesized and evaluated as potential multi-target agents against Alzheimer’s disease (AD). The results indicated that almost all the compounds displayed significant AChE inhibitory and selective activities. Besides, most of the derivatives exhibited increased self-induced Aβ1-42 aggregation inhibitory activity compared to the lead compound

  设计，合成和评估了一系列邻苯二甲酰基烷基叔胺衍生物，作为对抗阿尔茨海默氏病（AD）的潜在多靶标药物。结果表明，几乎所有化合物均显示出显着的AChE抑制和选择性活性。此外，大多数的衍生物显示出增加的自感甲β 1-42相比，铅化合物聚集抑制活性DL -NBP，有些化合物也发挥良好的抗氧化活性。具体而言，化合物I-8对AChE的抑制力最高（IC 50 = 2.66 nM），明显优于多奈哌齐（IC 50 = 26.4 nM）。此外，分子对接研究表明I-8可以与AChE的催化活性位点和外围阴离子位点结合。此外，化合物I-8在体外显示出优异的BBB渗透性。重要的是，逐步降低的被动回避测试表明，I-8可显着逆转东amine碱诱导的小鼠记忆缺陷。总的来说，这些结果表明I-8可能是用于进一步抗AD药物开发的有效且选择性的AChE抑制剂。
• USE OF NITROGEN COMPOUNDS QUATERNISED WITH ALKYLENE OXIDE AND HYDROCARBYL-SUBSTITUTED POLYCARBOXYLIC ACID AS ADDITIVES IN FUELS AND LUBRICANTS
  申请人：BASF SE

  公开号：US20160130514A1

  公开（公告）日：2016-05-12

  The invention relates to the use of quaternized nitrogen compounds as a fuel and lubricant additive or kerosene additive, such as in particular as a detergent additive, for decreasing or preventing deposits in the injection systems of direct-injection diesel engines, in particular in common rail injection systems, for decreasing the fuel consumption of direct-injection diesel engines, in particular of diesel engines having common rail injection systems, and for minimizing the power loss in direct-injection diesel engines, in particular in diesel engines having common rail injection systems; the invention further relates to the use as an additive for petrol, in particular for operation of DISI engines.

  该发明涉及将季铵化氮化合物用作燃料和润滑剂添加剂或煤油添加剂，特别是作为清洁剂添加剂，用于减少或预防直喷柴油发动机的喷射系统中的沉积物，在特定是在共轨喷射系统中，用于降低直喷柴油发动机的燃料消耗，特别是具有共轨喷射系统的柴油发动机，并用于减少直喷柴油发动机的功率损失，特别是在具有共轨喷射系统的柴油发动机中；该发明还涉及将其用作汽油添加剂，特别是用于DISI发动机的运行。
• Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogs)
  作者：Haim Leader、Richard K. Gordon、Jesse Baumgold、Victoria L. Boyd、Amy H. Newman、Ruthann M. Smejkal、Peter K. Chiang

  DOI：10.1021/jm00085a017

  日期：1992.4

  A series of aprophen [(N,N-diethylamino)ethyl 2,2-diphenylpropionate] analogues, called cylexphenes, were synthesized with alterations in (1) the chain length of the amine portion of the ester, (2) the alkyl groups on the amino alcohol, and (3) a cyclohexyl group replacing one of the phenyl rings. The antimuscarinic activities of these analogues were assessed in two pharmacological assays: the inhibition

  合成了一系列被称为cyphenphenes的二萘嵌苯酚[（N，N-二乙基氨基）乙基2,2-二苯基丙酸酯]类似物，其变化是（1）酯的胺部分的链长，（2）烷基上的烷基（3）取代苯环之一的环己基。在两个药理学分析中评估了这些类似物的抗毒蕈碱活性：抑制乙酰胆碱诱导的豚鼠回肠收缩，以及阻断卡巴胆碱刺激的大鼠胰腺腺泡细胞释放α-淀粉酶。这两个组织代表M3（回肠）和M3（胰腺）毒蕈碱受体亚型。此外，还评估了类似物对[3H] NMS与所选细胞膜结合的竞争抑制作用，每个细胞膜仅包含m1，M2，m3，或M4毒蕈碱受体亚型。m1和m3受体被稳定转染到A9 L细胞中。用环己基取代一个萘基的一个苯基，使所有类似物对胰腺泡毒蕈碱受体亚型的选择性比回肠亚型高10倍以上，其中（N，N-二甲基氨基）丙基类似物具有对胰腺受体亚型的最大选择性超过30倍。当检查[3H] NMS与M2亚型的结合时，与母体化合物相比，cycyphe
• Studies on Cognitive Enhancing Agents. III. Antiamnestic and Antihypoxic Activities of a Series of l-Bicycloaryl-2-(.OMEGA.-aminoalkoxy)ethanols.
  作者：Satoshi ONO、Tetsuo YAMAFUJI、Hisaaki CHAKI、Hajime MORITA、Yozo TODO、Naomi OKADA、Mutsuko MAEKAWA、Kazunori KITAMURA、Masaru TAI、Hirokazu NARITA

  DOI：10.1248/cpb.43.1492

  日期：——

  2-(2-Aminoethoxy)-1-hydroxyethyl derivatives of bicyclic arenes) naphthalene, thianaphthene, benzofuran, and indole) were prepared and screened for antiamnestic (AA) and antihypoxic (AH) activities which were evaluated by measuring the reversing potency in electroconvulsion-induced amnesia and the protective effect against hypoxia, respectively, in mice. Compound 3o, 1-(benzo[b]thiophen-5-yl)-2-(2-diethylaminoethoxy)ethanol, showed the best AA and AH activity profile, being superior to our prototype compound, 2-(2-dimethylaminoethoxy)-1-phenylethanol (1). Elongation of the ethylene linkage in the side chain of 3o to 3- and 4-carbon moiethies brought about a significant decrease in AH activity. Compound 3o was further investigated for its protective effect against Co2-induced memory impairment and for acute toxicity in mice. It is ten-fold more potent than tacrine in the amnesia-reversal assay and is considerably less toxic than tacrine.

  双环芳烃（萘、噻吊、苯并呋喃和吲哚）的2-(2-氨基乙氧基)-1-羟乙基衍生物被制备并筛选出具有抗遗忘（AA）和抗缺氧（AH）活性的化合物。这些活性通过测定逆转电休克诱导的遗忘和保护小鼠免受缺氧影响的效力来评估。化合物3o，1-(苯并[b]噻吩-5-基)-2-(2-二乙基氨基乙氧基)乙醇，显示出最佳的AA和AH活性特征，优于我们的原型化合物，2-(2-二甲基氨基乙氧基)-1-苯乙醇（1）。在3o的侧链中延长乙烯链接到3-和4-碳单元，显著降低了AH活性。化合物3o进一步研究了其对Co2诱导记忆障碍的保护作用和在小鼠中的急性毒性。在逆转遗忘试验中，其效力是他克林的十倍，并且毒性远低于他克林。
• Method for production of halogen-containing phthalocyanine compound
  申请人：Hirota Kouichi

  公开号：US20050203293A1

  公开（公告）日：2005-09-15

  This invention relates to a method for for the production of a halogen-containing phthalocyaline compound by the cyclization of phthalonitrile compounds either singly or in combination with a metal compound, characterized in effecting the cyclization in an organic compound having a hydroxyl group and/or a carboxylic acid in an amount in the range of 0.01-10 mass parts per one mass part of the phthalonitrile compounds while continuing the introduction of an inert gas. This method, by using a solvent capable of serving as a specific oxygen source destined to participate in the reaction of complexing a metal compound introduced into a phthalocyanine dye, permits the production of a phthalocyanine compound inexpensively in a high yield.

  这项发明涉及一种通过在具有羟基和/或羧酸的有机化合物中以每一部分邻苯二腈化合物0.01-10质量部的量的情况下，通过将邻苯二腈化合物单独或与金属化合物组合进行环化来生产含卤素的酞菁化合物的方法，其特征在于在继续引入惰性气体的同时进行环化。通过使用能够作为特定氧源的溶剂来参与将引入到酞菁染料中的金属化合物络合反应的方法，可以以高产率廉价地生产酞菁化合物。