4-octyloxypyridine | 37023-13-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-octyloxypyridine
• 英文别名: 4-Octoxypyridine
• CAS: 37023-13-5
• 化学式: C₁₃H₂₁NO
• 分子量: 207.316
• InChiKey: LCNBEJNFJVIDQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-octyloxypyridine 、 1,10-bis(phenyliodonium)-closo-decaborate 生成
  参考文献：
  名称：

  Highly quadrupolar derivatives of the [closo-B10H10]2- anion: Investigation of liquid crystalline polymorphism in an homologous series of 1,10-bis(4-alkoxypyridinium) zwitterions

  摘要：

  A series of pyridinium bis-zwitterions [closo-B10H8-1,10-2 (4-ROC5H4N)] (1[u]) was obtained in 55-60% yield by reacting [closo-B10H8-1,10-2(1Ph)] (3) with 4-alkoxypyridines and the resulting derivatives were analyzed for their liquid crystalline properties. Optical, thermal and XRD analyses revealed the formation of a nematic and rare lamellar phases, Lama, driven by dipolar interactions. Upon elongation of the terminal alkoxy chain, the nematic phase is gradually replaced by the lamellar polymorphism. The solidstate structures of 1[8], 1[12] and 1[16] were established by single crystal XRD:1[12] p-1,z=2,a= 9.6262 (2) angstrom,b = 12.0464(2) angstrom, c=12.611150(10) angstrom,beta=103.9910(10)degrees;1[12] p-1,Z=2,a=9.6262,(2) angstrom,b = 12.0464(2) angstrom, c=17.9226(3)angstrom, alpha=80.5940(10)degrees, beta= 83.0700(10)degrees, gamma=74.9860(10)degrees; 1[16] p-1, Z=2,a=9.6827 (3) angstrom,b = 11.6711 (5) angstrom, c= 22.8486(7) angstrom, alpha=77.416(3)degrees, beta = 86.925(2)degrees,gamma=66.202 (4)Alpha degrees

  DOI：

  10.1016/j.jorganchem.2018.04.003
• 作为产物：
  描述：

  辛醇 、 4-氯吡啶盐酸盐 在 sodium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 0.5h， 生成 4-octyloxypyridine
  参考文献：
  名称：

  4-烷氧基吡啶作为两性离子液晶中间体的合成

  摘要：

  在粉末 NaOH 存在下，通过 4-氯吡啶盐酸盐与适当的醇在 DMSO 中反应，以 75-80% 的典型收率获得了一系列 n = 5-18 的 4-烷氧基吡啶。将报告的合成与其他制备 4-烷氧基吡啶的方法进行比较，并对其用途进行了审查。4-十三烷氧基吡啶转化为 [closo-B10H10] 的双两性离子衍生物，呈现液晶相和软结晶相。通过单晶XRD方法建立了两种吡啶和双两性离子的固态结构。研究了 N 原子配位对吡啶环几何形状的影响。

  DOI：

  10.24820/ark.5550190.p010.700

文献信息

• Synthesis and Characterization of Neutral Cyclometalated Platinum(II) Complexes and their Antibacterial and Cytotoxic Evaluations
  作者：Wai‐Hong Yu、Sze‐Chun Yiu、Mei‐Tung Lau、Po‐Yu Ho、Pik‐Ling Lam、Chung‐Hin Chui、Wai‐Yeung Wong

  DOI：10.1002/ejic.202200529

  日期：2023.1.13

  A series of tridentate cyclometalated platinum(II) complexes were synthesized. They showed aggregation induced emission behaviors. Complex 1 showed a bactericidal activity against both Staphylococcus aureus (S. aureus) (MIC and MBC=3.13 μg/mL) and methicillin-resistant S. aureus (MIC and MBC=6.25 μg/mL) and did not possess noticeable cytotoxicity to human skin HaCaT keratinocytes.

  合成了一系列三齿环金属化铂 (II) 配合物。它们表现出聚集诱导的发射行为。复合物1显示出对金黄色葡萄球菌( S. aureus )（MIC 和 MBC=3.13 μg/mL）和耐甲氧西林金黄色葡萄球菌（MIC 和 MBC=6.25 μg/mL）的杀菌活性，并且对人体没有明显的细胞毒性皮肤 HaCaT 角质形成细胞。
• Two-photon absorption decolorizable material, two-photon absorption refractive index modulation material, two-photon absorption polymerization material, two-photon absorption polymerization method and three-dimensional optical recording material
  申请人：Takizawa Hiroo

  公开号：US20060083890A1

  公开（公告）日：2006-04-20

  A two-photon absorption decolorizable material comprising: a two-photon absorption dye executing a two-photon absorption; and a decolorizable dye having a molar absorption coefficient equal to or less than 100 at a wavelength of a light irradiated at the two-photon absorption, wherein the decolorizable dye is decolorized by an electron transfer or an energy transfer utilizing an excitation energy obtained by the two-photon absorption of the two-photon absorption dye.

  一种双光子吸收可脱色材料，包括：具有双光子吸收的双光子吸收染料；以及在双光子吸收处照射的光波长下摩尔吸收系数等于或小于 100 的可脱色染料，其中，利用双光子吸收染料的双光子吸收所获得的激发能量，通过电子转移或能量转移对可脱色染料进行脱色。
• US6054407A
  申请人：——

  公开号：US6054407A

  公开（公告）日：2000-04-25
• US7582391B2
  申请人：——

  公开号：US7582391B2

  公开（公告）日：2009-09-01
• Synthesis and Validation of TRIFAPYs as a Family of Transfection Agents for Therapeutic Oligonucleotides
  作者：Berta Isanta、Ana Delgado、Carlos J. Ciudad、Mª Antònia Busquets、Rosa Griera、Núria Llor、Véronique Noé

  DOI：10.3390/biom14040390

  日期：——

  Transfection agents play a crucial role in facilitating the uptake of nucleic acids into eukaryotic cells offering potential therapeutic solutions for genetic disorders. However, progress in this field needs the development of improved systems that guarantee efficient transfection. Here, we describe the synthesis of a set of chemical delivery agents (TRIFAPYs) containing alkyl chains of different lengths based on the 1,3,5-tris[(4-alkyloxy-1pyridinio)methyl]benzene tribromide structure. Their delivery properties for therapeutic oligonucleotides were evaluated using PolyPurine Reverse Hoogsteen hairpins (PPRHs) as a silencing tool. The binding of liposomes to PPRHs was evaluated by retardation assays in agarose gels. The complexes had a size of 125 nm as determined by DLS, forming well-defined concentrical vesicles as visualized by Cryo-TEM. The prostate cancer cell line PC-3 was used to study the internalization of the nanoparticles by fluorescence microscopy and flow cytometry. The mechanism of entrance involved in the cellular uptake was mainly by clathrin-mediated endocytosis. Cytotoxicity analyses determined the intrinsic toxicity caused by each TRIFAPY and the effect on cell viability upon transfection of a specific PPRH (HpsPr-C) directed against the antiapoptotic target survivin. TRIFAPYs C12-C18 were selected to expand these studies in the breast cancer cell line SKBR-3 opening the usage of TRIFAPYs for both sexes and, in the hCMEC/D3 cell line, as a model for the blood–brain barrier. The mRNA levels of survivin decreased, while apoptosis levels increased upon the transfection of HpsPr-C with these TRIFAPYs in PC-3 cells. Therefore, TRIFAPYs can be considered novel lipid-based vehicles for the delivery of therapeutic oligonucleotides.