5'-O-(tert-butyldimethylsilyl)-6-iodo-2',3'-O-isopropylideneuridine | 142682-82-4
中文名称
——
中文别名
——
英文名称
5'-O-(tert-butyldimethylsilyl)-6-iodo-2',3'-O-isopropylideneuridine
英文别名
1-[(3aR,4R,6R,6aR)-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-6-iodopyrimidine-2,4-dione
CAS
142682-82-4
化学式
C18H29IN2O6Si
mdl
——
分子量
524.428
InChiKey
HGPNIKGIDVEPCW-JUDXGUMMSA-N
BEILSTEIN
——
EINECS
——
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
物化性质
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密度：1.48±0.1 g/cm3(Predicted)
计算性质
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辛醇/水分配系数(LogP)：2.58
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重原子数：28
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可旋转键数：5
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环数：3.0
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sp3杂化的碳原子比例：0.78
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拓扑面积：86.3
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氢给体数：1
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氢受体数：6
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 —— 5'-O-(t-butyldimethylsilyl)-2',3'-O-isopropylideneuridine 102147-76-2 C18H30N2O6Si 398.531 2’,3’邻异亚丙基尿苷 2',3'-O-isopropylideneuridine 362-43-6 C12H16N2O6 284.269 尿嘧啶核苷 uridine 58-96-8 C9H12N2O6 244.204 -
下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— 1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-iodopyrimidine-2,4(1H,3H)-dione 1258599-28-8 C12H15IN2O6 410.165 —— 2',3',5'-tris-O-(tert-butyldimethylsilyl)-6-iodouridine 223776-15-6 C27H53IN2O6Si3 712.889 —— 5'-O-(t-butyldimethylsilyl)-6-N-methylamino-2',3'-O-isopropylidene-uridine 934014-48-9 C19H33N3O6Si 427.573 —— 5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene-6-vinyluridine 159506-69-1 C20H32N2O6Si 424.569 —— 5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene-6-cyanouridine 869880-90-0 C19H29N3O6Si 423.541 —— 6-iodouridine 105967-11-1 C9H11IN2O6 370.101 —— 6-azido-5'-O-(t-butyldimethylsilyl)-2',3'-O-isopropylideneuridine 908354-36-9 C18H29N5O6Si 439.544 —— 6-iodouridine 5'-monophosphate 931581-04-3 C9H12IN2O9P 450.081 —— 1-((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpyrimidine-2,4(1H,3H)-dione 142682-84-6 C24H34N2O6Si 474.629 —— 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(p-methoxyphenyl)uridine 1311164-84-7 C25H36N2O7Si 504.656 —— 1-((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-(naphthalen-2-yl)pyrimidine-2,4(1H,3H)-dione 1258599-19-7 C28H36N2O6Si 524.689 —— 1-((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-(4-tert-butylphenyl)pyrimidine-2,4(1H,3H)-dione 1258599-20-0 C28H42N2O6Si 530.737 —— 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(3-thiophenyl)uridine 1311164-85-8 C22H32N2O6SSi 480.657 —— 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(3-furanyl)uridine 1311164-86-9 C22H32N2O7Si 464.591 —— 1-((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpyrimidine-2,4(1H,3H)-dione 1258599-21-1 C22H32N2O7Si 464.591 —— 1-((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-(thiophen-2-yl)pyrimidine-2,4(1H,3H)-dione 1258599-22-2 C22H32N2O6SSi 480.657 —— 2',3',5'-tris-O-(tert-butyldimethylsilyl)-6-vinyluridine 223776-16-7 C29H56N2O6Si3 613.03 —— 2',3',5'-Tri-O-(tert-butyldimethylsilyl)uridine-6-carboxaldehyde 223776-18-9 C28H54N2O7Si3 615.002 —— 2',3',5'-tris-O-(tert-butyldimethylsilyl)-6-(hydroxymethyl)uridine 198622-32-1 C28H56N2O7Si3 617.018 —— 2',3',5'-tris-O-(tert-butyldimethylsilyl)-6-<(1-hydroxy)ethyl>uridine 223776-19-0 C29H58N2O7Si3 631.045 —— 2',3',5'-tris-O-(tert-butyldimethylsilyl)-6-<(R)-(1-hydroxy)ethyl>uridine 223776-33-8 C29H58N2O7Si3 631.045 —— 2',3',5'-tris-O-(tert-butyldimethylsilyl)-6-<(S)-(1-hydroxy)ethyl>uridine 223776-34-9 C29H58N2O7Si3 631.045 —— 2',3',5'-tris-O-(tert-butyldimethylsilyl)-6-(1,2-dihydroxyethyl)uridine 223776-17-8 C29H58N2O8Si3 647.045 —— 2',3',5'-tris-O-(tert-butyldimethylsilyl)-6-acetyluridine 223776-20-3 C29H56N2O7Si3 629.029 —— 2',3',5'-tris-O-(tert-butyldimethylsilyl)-6-<(1-hydroxy-1-methyl)ethyl>uridine 223776-21-4 C30H60N2O7Si3 645.072 —— 6-[[[tert-Butyldimethylsilyl]oxy]methyl]-3,4-[[tert-butyldimethylsilyl]oxy]-[2aR,3a,4a,5b]-spiro[furan-2[3H],3'-[3H]oxazolo[3,4-c]pyrimidine]-5',7'(1'H,6'H)-dione 198622-33-2 C28H54N2O7Si3 615.002 —— 6-N-methylamino-uridine 74653-06-8 C10H15N3O6 273.246 —— 2',3',5'-tris-O-(tert-butyldimethylsilyl)-6,1'-<2,2-dimethyl-1-oxaethano>uridine 223776-27-0 C30H58N2O7Si3 643.056 —— 6-cyanouridine 68184-19-0 C10H11N3O6 269.214 —— 6-N-methylamino-uridine-5'-O-monophosphate 97557-27-2 C10H16N3O9P 353.226 —— 6-azidouridine 101814-74-8 C9H11N5O6 285.216 —— 6,1'-(1-oxaethano)uridine 198622-34-3 C10H12N2O7 272.214 —— 6-azido-5'-UMP 921197-75-3 C9H12N5O9P 365.196 —— 6-(2-thienyl)uridine 110085-67-1 C13H14N2O6S 326.33 —— 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-phenylpyrimidine-2,4(1H,3H)-dione 110085-65-9 C15H16N2O6 320.302 —— 6-(p-methoxyphenyl)uridine 1311164-98-3 C16H18N2O7 350.328 —— 6-(3-furanyl)uridine 1311165-02-2 C13H14N2O7 310.263 —— 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-(naphthalen-2-yl)pyrimidine-2,4(1H,3H)-dione 1258599-23-3 C19H18N2O6 370.362 —— 6-(3-thienyl)uridine 1311165-01-1 C13H14N2O6S 326.33 - 1
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反应信息
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作为反应物：描述：5'-O-(tert-butyldimethylsilyl)-6-iodo-2',3'-O-isopropylideneuridine 在 吡啶 、 水 、 三乙胺 、 三氟乙酸 、 三氯氧磷 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 7.0h， 生成 6-N-methylamino-uridine-5'-O-monophosphate