Isopentyl-phosphonsaeure-dichlorid | 5022-00-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• 英文名称: Isopentyl-phosphonsaeure-dichlorid
• 英文别名: 1-Dichlorophosphoryl-3-methylbutane
• CAS: 5022-00-4
• 化学式: C₅H₁₁Cl₂OP
• 分子量: 189.022
• InChiKey: AZLUSPOYOXQLMB-UHFFFAOYSA-N

物化性质

• 沸点：
  92-99 °C(Press: 14 Torr)
• 密度：
  1.2294 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Isopentyl-phosphonsaeure-dichlorid 在 正丁基锂 、 potassium tert-butylate 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 82.75h， 生成 cis-3-(3-tert-butyl-4,5-diphenyl-2-oxo-1,3,2-oxazaphosphorinan-2-yl)-3,5-dimethylhexan-2-one
  参考文献：
  名称：

  非对映选择性合成α，α'-二取代的β-酮膦酸酯衍生物，作为自动合成的基础

  摘要：

  α，α'-β二取代- ketophosphonic衍生物的良好的方便和有效的合成以优良的解，接着手性5-元环phosphonamidates的非对映选择性α烷基化的和产率已经由α-酰化来实现。

  DOI：

  10.1016/j.jorganchem.2004.10.042
• 作为产物：
  描述：

  2-甲基丁烷 在 氧气 、 三氯化磷 作用下， 生成 Isopentyl-phosphonsaeure-dichlorid
  参考文献：
  名称：

  Integrins in Head and Neck Squamous Cell Carcinoma Invasion

  摘要：

  AbstractObjective To relate the invasive properties of different squamous cell cancer cell lines to the function and expression of the integrins.Study Design A series of in vitro and in vivo experiments were designed to assess and compare integrin expression and function in two different head and neck squamous cell carcinoma cell lines.Methods Invasive properties of two squamous cell carcinoma cell lines (UM‐SCC‐1 and JHU‐022‐SCC) were assessed using an in vitro artificial matrix assay as well as an in vivo system with orthotopically implanted tumor cells in mice. Whole cell and surface expression levels of integrin subunits (alpha2, alpha3, alpha5, alpha6, beta1, and beta4) were determined for each cell line using Western blot analysis and flow cytometry. We compared the ability of JHU‐022‐SCC and UM‐SCC‐1 cells to bind the extracellular matrix elements collagen IV, fibronectin, laminin 5, and laminin10 using an in vitro adhesion assay. Contributions of the different integrins to the adhesive properties were determined by selective antibody blocking of different subunits.Results The UM‐SCC‐1 cell line is 50% more invasive in vitro and displays a greater propensity for perineural and lymphatic invasion in vivo. The UM‐SCC‐1 cells exhibited greater adherence to fibronectin than JHU‐022‐SCC cells. Alpha6 and beta4 expression is approximately twofold greater in the JHU‐022‐SCC cells. Alpha2, alpha3, and beta1 expression appears to be upregulated in UM‐SCC‐1 cells.Conclusion The UM‐SCC‐1 carcinoma cells are more invasive than JHU‐022‐SCC cells and may be related to differential expression of the integrins alpha6beta4, alpha3beta1, and alpha2beta1.

  DOI：

  10.1097/00005537-200211000-00021

文献信息

• Patois, C.; Berte-Verrando, S.; Savignac, P., Bulletin de la Societe Chimique de France, 1993, vol. 130, p. 485 - 487
  作者：Patois, C.、Berte-Verrando, S.、Savignac, P.

  DOI：——

  日期：——
• Guichard, Chemische Berichte, 1899, vol. 32, p. 1574
  作者：Guichard

  DOI：——

  日期：——
• Zhmurova,I.N.; Voitsekhovskaya,I.Yu., Journal of general chemistry of the USSR, 1965, vol. 35, p. 2185 - 2187
  作者：Zhmurova,I.N.、Voitsekhovskaya,I.Yu.

  DOI：——

  日期：——
• Bogonostseva,N.P.; Filippova,T.E., Journal of general chemistry of the USSR, 1963, vol. 33, p. 1332 - 1334
  作者：Bogonostseva,N.P.、Filippova,T.E.

  DOI：——

  日期：——
• CN116947926
  申请人：——

  公开号：——

  公开（公告）日：——