11-oxo-18α-olean-12-ene-3β,30-diol | 60209-40-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 11-oxo-18α-olean-12-ene-3β,30-diol
• 英文别名: (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bS)-10-hydroxy-2-(hydroxymethyl)-2,4a,6a,6b,9,9,12a-heptamethyl-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picen-13-one
• CAS: 60209-40-7
• 化学式: C₃₀H₄₈O₃
• 分子量: 456.709
• InChiKey: JCGXIYQLRYPHDG-DVAIWGJFSA-N

物化性质

• 沸点：
  559.3±50.0 °C(predicted)
• 密度：
  1.10±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  33
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  18α-甘草次酸 在 manganese(IV) oxide 、 lithium aluminium tetrahydride 作用下， 生成 11-oxo-18α-olean-12-ene-3β,30-diol
  参考文献：
  名称：

  Anti-tumor-promoter activity of modified glycyrrhetinic acid derivatives. Synthesis and structure-activity relationships

  摘要：

  A series of modified derivatives of 18alpha- and 18beta-glycyrrhetinic acid was systematically synthesized and their structure-activity relationships investigated for inhibition of the promoter activity of 12-O-tetradecanoylphorbol-13-acetate in vitro. Increased hydrophobicity in the A-ring moiety and the presence of an 11-oxo function were shown to be important for the high inhibition. Replacement of the carboxy to the hydroxymethyl group at the 20-position also enhanced the inhibitory activity.

  DOI：

  10.1016/0223-5234(92)90088-i

文献信息

• Anti-tumor-promoter activity of modified glycyrrhetinic acid derivatives. Synthesis and structure-activity relationships
  作者：T Terasawa、T Okada、H Nishino

  DOI：10.1016/0223-5234(92)90088-i

  日期：1992.10

  A series of modified derivatives of 18alpha- and 18beta-glycyrrhetinic acid was systematically synthesized and their structure-activity relationships investigated for inhibition of the promoter activity of 12-O-tetradecanoylphorbol-13-acetate in vitro. Increased hydrophobicity in the A-ring moiety and the presence of an 11-oxo function were shown to be important for the high inhibition. Replacement of the carboxy to the hydroxymethyl group at the 20-position also enhanced the inhibitory activity.