对异丙氧基苯基琥珀酸酐 | 32857-73-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 对异丙氧基苯基琥珀酸酐
• 英文名称: p-Isopropoxyphenylsuccinic anhydride
• 英文别名: (4-isopropoxyphenyl)succinic acid anhydride；3-[4-(Propan-2-yloxy)phenyl]oxolane-2,5-dione；3-(4-propan-2-yloxyphenyl)oxolane-2,5-dione
• CAS: 32857-73-1
• 化学式: C₁₃H₁₄O₄
• 分子量: 234.252
• InChiKey: XEXKXFHRPOAUDB-UHFFFAOYSA-N

物化性质

• 沸点：
  401.7±45.0 °C(Predicted)
• 密度：
  1.205±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.03
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  对异丙氧基苯基琥珀酸酐 在 一水合肼 作用下， 以 溶剂黄146 为溶剂， 反应 4.0h， 以72%的产率得到N,N'-Bis-(p-isopropoxyphenylsuccinimide)
  参考文献：
  名称：

  Relationship between chemical structure and anticonvulsant activity in succinimides

  摘要：

  DOI：

  10.1007/bf00768251
• 作为产物：
  描述：

  2-(4-异丙氧基苯基)琥珀酸 在 乙酸酐 作用下， 生成 对异丙氧基苯基琥珀酸酐
  参考文献：
  名称：

  Synthesis of New Diazamantane Derivatives Containing a 2-Phenylimide Substituent

  摘要：

  DOI：

  10.1134/s1070428023050093

文献信息

• Investigations in the field of semisynthetic penicillins. IX. 6-Aminopenicillanic derivatives of p-alkoxyphenyl- and p-alkoxybenzylsuccinic acids. monopenicillins
  作者：A. L. Mndzhoyan、Sh. L. Mndzhoyan、I. Z. Manucharyan、Yu. Z. Ter-Zakharyan、L. A. Shatverova、R. V. Agababyan

  DOI：10.1007/bf00758504

  日期：1976.6

  i. A.P. Terent'ev and L. A. Yanovskaya, in: Reactions and Methods of Investigating Organic Compounds [in Russian], Moscow, Vol. 6 (1957), p. 7. 2. A. Yu. Ibadov, Tr. Tashk. Farm. ~ Inst., 2, 225 (1960); Med. Prom. SSSR, No. 9, 59 (1965). 3. G. Dyson, May's Chemistry of Synthetic Drugs, 5th ed., Longmans, London (1959). 4. State Pharmacopoeia of the USSR [in Russian], 10th ed., Moscow (1968), p. 1078

  一世。AP Terent'ev 和 LA Yanovskaya，在：反应和调查有机化合物的方法 [俄语]，莫斯科，卷。6 (1957), p. 7. 2. A. Yu。伊巴多夫，Tr。塔什克。农场。~ Inst., 2, 225 (1960); 医学。舞会。SSSR, No. 9, 59 (1965)。3. G. Dyson，May 的《合成药物化学》，第 5 版，Longmans，伦敦（1959 年）。4. 苏联国家药典 [俄文]，第 10 版，莫斯科（1968 年），p。1078. 5. AI Roshchenko 和 MN Dikhanov，Farmats。Zh., No. I, 15 (1964)。
• SYNTHESIS AND ANTICONVULSANT PROPERTIES OF SOME N-ARYL AND N-ARYLAMINOMETHYL DERIVATIVES OF 3-P-ISOPROPOXYPHENYLPYRROLIDINE-2,5-DIONE
  作者：Sergey Kocharov、Henry Panosyan、Jaroslaw Chmielewski、Barbara Gworek、Jarogniew Łuszczki

  DOI：10.32383/appdr/97323

  日期：2019.4.30

  Anticonvulsant properties of newly synthesized compounds and potential antiepileptic drugs are usually assessed in screen tests in experimental animals. One of the most commonly used screen tests in mice is the maximal electroshock-induced seizure test that reflects tonic-clonic seizures in humans. A series of 3-p-isopropoxyphenylpyrrolidine- 2,5-dione derivatives, including N-aryl and N-arylaminomethyl analogs, were characterized for their anticonvulsant properties in the maximal electroshock-induced seizure test in mice. Electroconvulsions (tonic-clonic seizures) were evoked in adult Albino Swiss mice by a current (sine-wave, 25 mA, 50 Hz, 500 V, 0.2 s stimulus duration) delivered via auricular electrodes. N-aryl derivatives did not show any anticonvulsant activity, whereas some representatives of N-arylaminomethyl derivatives, i.e. N-Mannich bases, exhibited a distinct protective action against maximal electroshock-induced (MES) convulsions in mice. Several N-arylaminomethyl derivatives of 3-p-isopropoxyphenylpyrrolidine-2,5-dione may become in future new antiepileptic drugs, or they could serve as valuable supporting materials for obtaining new derivatives with stronger anticonvulsant activities than their maternal compounds.
• AVETISYAN, S. A.;NESUNTS, N. S.;BUYUKYAN, N. S.;MNDZHOYAN, O. L.;DZHAGATS+, XIM.-FARMATS. ZH., 22,(1988) N 4, 433-438
  作者：AVETISYAN, S. A.、NESUNTS, N. S.、BUYUKYAN, N. S.、MNDZHOYAN, O. L.、DZHAGATS+

  DOI：——

  日期：——