2-(4-异丙氧基苯基)琥珀酸 | 27950-67-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 中文名称: 2-(4-异丙氧基苯基)琥珀酸
• 英文名称: p-isopropoxyphenylsuccinic acid
• 英文别名: (4-isopropoxy-phenyl)-succinic acid；2-[4-(Propan-2-yloxy)phenyl]butanedioic acid；2-(4-propan-2-yloxyphenyl)butanedioic acid
• CAS: 27950-67-0
• 化学式: C₁₃H₁₆O₅
• mdl: MFCD00298258
• 分子量: 252.267
• InChiKey: FPHZIGCDKMMMHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  2-(4-异丙氧基苯基)琥珀酸 在 乙酸酐 作用下， 生成 对异丙氧基苯基琥珀酸酐
  参考文献：
  名称：

  Synthesis of New Diazamantane Derivatives Containing a 2-Phenylimide Substituent

  摘要：

  DOI：

  10.1134/s1070428023050093

文献信息

• Investigations in the field of semisynthetic penicillins. VIII. 6-aminopenicillanic acid derivatives of p-alkoxyphenyl- and benzylsuccinic acids
  作者：A. L. Mndzhoyan、M. T. Grigoryan、S. O. Vardanyan、V. O. Nazaryan、Yu. Z. Ter-Zakharyan、Sh. G. Oganyan、L. P. Zhuravleva、Sh. L. Mndzhoyan

  DOI：10.1007/bf00764283

  日期：1976.1

  i. K.P. Khomyakov, A. D. Virnik, and Z. A. Rogovin, Usp. Khim., 33, 1051-1059 (1964). 2. T.I. Kozulitsina, A. D. Virnik, K. P. Khomyakov, et al., Vopr. Med. Khim., 14, 375378 (1968). 3. V.I. Snezhko, L. N. Samoilova, K. P. Khomyakov, et al., Antibiotiki, No. 1,48-52(1972). 4. A.E. Vasil'ev, G. F. Zhukova, G. A. Ravdel', et al., Zh. Obshch. Khim., 43, 25292532 (1973). 5. G.F. Zhukova, G. A. Ravdel'

  一世。KP Khomyakov、AD Virnik 和 ZA Rogovin，Usp。Khim., 33, 1051-1059 (1964)。2. TI Kozulitsina、AD Virnik、KP Khomyakov 等人，Vopr。医学。Khim., 14, 375378 (1968)。3. VI Snezhko, LN Samoilova, KP Khomyakov, et al., Antibiotiki, No. 1,48-52(1972)。4. AE Vasil'ev、GF Zhukova、GA Ravdel'等人，Zh。奥布希。Khim., 43, 25292532 (1973)。5. GF Zhukova, GA Ravdel' 和 LA Shchukina, Zh。奥布希。Khim., 40, 2753-2757 (1970)。6. NK Kochetkov、AA Khachaturyan、AE
• SYNTHESIS AND ANTICONVULSANT PROPERTIES OF SOME N-ARYL AND N-ARYLAMINOMETHYL DERIVATIVES OF 3-P-ISOPROPOXYPHENYLPYRROLIDINE-2,5-DIONE
  作者：Sergey Kocharov、Henry Panosyan、Jaroslaw Chmielewski、Barbara Gworek、Jarogniew Łuszczki

  DOI：10.32383/appdr/97323

  日期：2019.4.30

  Anticonvulsant properties of newly synthesized compounds and potential antiepileptic drugs are usually assessed in screen tests in experimental animals. One of the most commonly used screen tests in mice is the maximal electroshock-induced seizure test that reflects tonic-clonic seizures in humans. A series of 3-p-isopropoxyphenylpyrrolidine- 2,5-dione derivatives, including N-aryl and N-arylaminomethyl analogs, were characterized for their anticonvulsant properties in the maximal electroshock-induced seizure test in mice. Electroconvulsions (tonic-clonic seizures) were evoked in adult Albino Swiss mice by a current (sine-wave, 25 mA, 50 Hz, 500 V, 0.2 s stimulus duration) delivered via auricular electrodes. N-aryl derivatives did not show any anticonvulsant activity, whereas some representatives of N-arylaminomethyl derivatives, i.e. N-Mannich bases, exhibited a distinct protective action against maximal electroshock-induced (MES) convulsions in mice. Several N-arylaminomethyl derivatives of 3-p-isopropoxyphenylpyrrolidine-2,5-dione may become in future new antiepileptic drugs, or they could serve as valuable supporting materials for obtaining new derivatives with stronger anticonvulsant activities than their maternal compounds.
• Synthesis of New Diazamantane Derivatives Containing a 2-Phenylimide Substituent
  作者：S. L. Kocharov、K. A. Gevorkyan、A. D. Arutyunyan、M. V. Galstyan、H. A. Panosyan、J. A. Avakimyan、H. M. Stepanyan

  DOI：10.1134/s1070428023050093

  日期：2023.5