双(2-氯苯基)磷酰氯 | 17776-78-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 双(2-氯苯基)磷酰氯
• 英文名称: bis(2-chlorophenyl) chlorophosphate
• 英文别名: bis(2-chlorophenyl)chlorophosphate；chlorophosphoric acid bis-(2-chloro-phenyl ester)；Chlorophosphorsaeure-bis-(2-chlor-phenylester)；Bis(2-chlorophenyl) phosphorochloridate；1-chloro-2-[chloro-(2-chlorophenoxy)phosphoryl]oxybenzene
• CAS: 17776-78-2
• 化学式: C₁₂H₈Cl₃O₃P
• mdl: MFCD00015736
• 分子量: 337.526
• InChiKey: ZLSGEMKKBUVQOM-UHFFFAOYSA-N

物化性质

• 沸点：
  184-186°C 0,4mm
• 密度：
  1.465
• 闪点：
  184-186°C/0.4mm
• 稳定性/保质期：

  在常温常压下稳定，应避免接触水分、潮湿、氧化物和碱。

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险等级：
  8
• 危险类别码：
  R34
• 危险品运输编号：
  UN 3265
• 包装等级：
  III
• 危险类别：
  8
• 安全说明：
  S26,S36/37/39,S45
• 储存条件：
  常温下应密闭、避光保存，并放置于通风、干燥的环境中，在惰性气体保护下更为理想。

反应信息

• 作为反应物：
  描述：

  双(2-氯苯基)磷酰氯 在 水 作用下， 反应 13.0h， 以59%的产率得到phosphoric acid bis-(2-chloro-phenyl ester)
  参考文献：
  名称：

  Hydrogen phosphates: Self initiated organocatalysts for the controlled ring-opening polymerization of cyclic esters

  摘要：

  A series of arylhydrogenphosphates and aryldihydrogenphosphates was synthesized and characterized using spectroscopic methods and single crystal X-ray diffraction. These compounds were assessed as catalysts towards the ring-opening polymerization and proved to be potent organocatalysts for the ring-opening polymerization of cyclic esters. The bulk polymerizations were performed in the absence of external initiator. The polymerization proceeds in a controlled fashion which leads to well defined polyesters with narrow molecular weight distributions. In the post polymerization experiments, kinetics, mechanism and monomer concentration effects were investigated. The kinetic results have confirmed the pseudo-living character of the polymerizations and mechanistic studies suggest that the polymerization operates through a cationic mechanism. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.02.006
• 作为产物：
  描述：

  邻氯苯酚 在 lithium chloride 、 三氯氧磷 作用下， 反应 48.0h， 以59%的产率得到双(2-氯苯基)磷酰氯
  参考文献：
  名称：

  Hydrogen phosphates: Self initiated organocatalysts for the controlled ring-opening polymerization of cyclic esters

  摘要：

  A series of arylhydrogenphosphates and aryldihydrogenphosphates was synthesized and characterized using spectroscopic methods and single crystal X-ray diffraction. These compounds were assessed as catalysts towards the ring-opening polymerization and proved to be potent organocatalysts for the ring-opening polymerization of cyclic esters. The bulk polymerizations were performed in the absence of external initiator. The polymerization proceeds in a controlled fashion which leads to well defined polyesters with narrow molecular weight distributions. In the post polymerization experiments, kinetics, mechanism and monomer concentration effects were investigated. The kinetic results have confirmed the pseudo-living character of the polymerizations and mechanistic studies suggest that the polymerization operates through a cationic mechanism. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.02.006
• 作为试剂：
  描述：

  N4-苯甲酰基-5′-O-(4,4′-二甲氧基三苯基)-2′-脱氧胞苷 在 吡啶 、 盐酸 、 4-二甲氨基吡啶 、 双(2-氯苯基)磷酰氯 、 三乙胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 2.49h， 生成 [(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[[(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl]oxy-(4-chlorophenyl)sulfanylphosphoryl]oxymethyl]oxolan-3-yl] 4-oxopentanoate
  参考文献：
  名称：

  Reese, Colin B.; Quanlai, Song, Journal of the Chemical Society. Perkin transactions I, 1999, # 11, p. 1477 - 1486

  摘要：

  DOI：

文献信息

• [EN] TRI-FUNCTIONAL CROSSLINKING REAGENTS<br/>[FR] RÉACTIFS DE RÉTICULATION TRIFONCTIONNELS
  申请人：ETH ZUERICH

  公开号：WO2017081069A1

  公开（公告）日：2017-05-18

  The present invention relates to tri-functional crosslinking reagents carrying (i) a ligand-reactive group for conjugation to a ligand of interest having at least one binding site on a target glycoprotein receptor, (ii) a hydrazone group for the capturing of oxidized receptor-glycoproteins and (iii) an affinity group selected from azides and aklynes for the detection, isolation and purification of captured glycoproteins; as well as their manufacturing. The invention further provides for improved methods of detecting, identifying and characterizing interactions between ligands and their corresponding target glycoproteins on living cells and in biological fluids. The invention further provides for new uses of catalysts in such methods.

  本发明涉及携带（i）与感兴趣的配体结合的配体反应性基团，该配体在目标糖蛋白受体上至少具有一个结合位点，（ii）用于捕获氧化受体-糖蛋白的缩醛基团，以及（iii）从叠氮化物和炔烃中选择的亲和基团，用于检测、分离和纯化捕获的糖蛋白的三功能交联试剂；以及它们的制造。本发明还提供了改进的方法，用于检测、识别和表征配体与其相应目标糖蛋白在活细胞和生物体液中的相互作用。本发明还提供了在这些方法中使用催化剂的新用途。
• Nucleotide, XVIII. Synthese und Eigenschaften von (tert-Butyldimethylsilyl)guanosinen, Guanosin-3?-phosphotriestern und Guanosin-haltigen Oligoncleotiden
  作者：Dieter Flockerzi、Wilhelm Schlosser、Wolfgang Pfleiderer

  DOI：10.1002/hlca.19830660718

  日期：1983.11.2

  Nucleotides, XVIII. Synthesis and Properties of (tert-Butyldimethylsilyl)guanosines, Guanosine-3′-Phosphotriesters and Guanosine-containing Oligonucleotides

  核苷酸，十八。（叔丁基二甲基甲硅烷基）鸟苷，鸟苷-3'-磷酸三酯和含鸟苷的寡核苷酸的合成及性能
• Butyrylcholinesterase Inhibitors
  申请人：JAL Therapeutics, LLC

  公开号：US20160206635A1

  公开（公告）日：2016-07-21

  Butyrylcholinesterase inhibitors, their formulation, and their use primarily in the treatment of neurodegenerative diseases. These inhibitors generally are phosphates, phosphonates, phosphinates, and phosphoramidates. These inhibitors can be incorporated in pharmaceutical compositions and administered to a patient in therapeutically effective amounts to treat neurodegenerative diseases.

  丁酰胆碱酯酶抑制剂，它们的配方，以及它们主要用于治疗神经退行性疾病。这些抑制剂通常是磷酸酯、膦酸酯、膦酸酯和磷酰胺酯。这些抑制剂可以被纳入药物组成，并以治疗有效量的方式给患者使用，以治疗神经退行性疾病。
• 2-5A ANALOGS AND THEIR METHODS OF USE
  申请人：Beigelman Leonid

  公开号：US20100331397A1

  公开（公告）日：2010-12-30

  Disclosed herein are compounds that activate RNaseL, methods of synthesizing compounds that activate RNaseL and the use of compounds that activate RNaseL for treating and/or ameliorating a disease or a condition, such as a viral infection, a bacterial infection, cancer and/or parasitic disease.

  本文披露了激活RNaseL的化合物，合成激活RNaseL的化合物的方法，以及利用激活RNaseL的化合物治疗和/或改善疾病或状况的用途，例如病毒感染、细菌感染、癌症和/或寄生虫病。
• BUTYRYLCHOLINESTERASE INHIBITORS
  申请人：Acey Roger A.

  公开号：US20100069337A1

  公开（公告）日：2010-03-18

  Butyrylcholinesterase inhibitors, their formulation, and their use primarily in the treatment of neurodegenerative diseases. These inhibitors generally are phosphates, phosphonates, phosphinates, and phosphoramidates. These inhibitors can be incorporated in pharmaceutical compositions and administered to a patient in therapeutically effective amounts to treat neurodegenerative diseases.

  丁酰胆碱酯酶抑制剂，它们的配方，主要用于治疗神经退行性疾病。这些抑制剂通常是磷酸酯、膦酸酯、膦酸酯和磷酰胺酯。这些抑制剂可以被纳入药物组合物中，并以治疗有效剂量的形式给患者使用，以治疗神经退行性疾病。

表征谱图