3-chloroacetyl-2,2'-biindolyl | 172950-84-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-chloroacetyl-2,2'-biindolyl
• 英文别名: 2-chloro-1-[2-(1H-indol-2-yl)-1H-indol-3-yl]ethanone
• CAS: 172950-84-4
• 化学式: C₁₈H₁₃ClN₂O
• 分子量: 308.767
• InChiKey: ZSOGZBHMVGALMF-UHFFFAOYSA-N

物化性质

• 沸点：
  614.7±50.0 °C(predicted)
• 密度：
  1.387±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  48.6
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-chloroacetyl-2,2'-biindolyl 在 三正丁基氢锡 作用下， 生成 3-acetyl-2,2'-bisindole
  参考文献：
  名称：

  Simple Synthesis of 2,2'-Bisindole from Indigo and Its Application for the Syntheses of Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-(6H)dione and -5-(6H)one Derivatives

  摘要：

  Indigo was converted to 2,2'-bisindole, from which 6-substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-(6H)dione and -5-(6H)one derivatives were prepared in short steps. Bromination of 6-methylindolo[2,3-a]pyrrolo[3,4-c]carbazole5,7-(6H)dione is also reported.

  DOI：

  10.3987/com-95-7192
• 作为产物：
  描述：

  1H,1H'-2,2'-Biindolylidene-3,3'-dione 在 乙酸酐 、 溶剂黄146 、 锌 作用下， 以 乙酸乙酯 为溶剂， 反应 8.0h， 生成 3-chloroacetyl-2,2'-biindolyl
  参考文献：
  名称：

  Simple Synthesis of 2,2'-Bisindole from Indigo and Its Application for the Syntheses of Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-(6H)dione and -5-(6H)one Derivatives

  摘要：

  Indigo was converted to 2,2'-bisindole, from which 6-substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-(6H)dione and -5-(6H)one derivatives were prepared in short steps. Bromination of 6-methylindolo[2,3-a]pyrrolo[3,4-c]carbazole5,7-(6H)dione is also reported.

  DOI：

  10.3987/com-95-7192

文献信息

• Short Step Syntheses of a Natural Product, 6-Cyano-5-methoxy-12-methylindolo[2,3-a]carbazole and Novel 6-Aminoindolo[2,3-a]thiazolo[5,4-c]carbazoles
  作者：Masanori Somei、Hiroyuki Hayashi、Yoshiaki Suzuki

  DOI：10.3987/com-99-8531

  日期：——
• The First Syntheses of Antiviral, Cytotoxic 6-Cyano-5-methoxy- and -12-methylindolo[2,3-a]carbazoles, and Related Indolo[2,3-a]carbazoles from Indigo
  作者：Masanori Somei、Hiroyuki Hayashi、Shinobu Ohmoto

  DOI：10.3987/com-97-7848

  日期：——
• Simple Synthesis of 2,2'-Bisindole from Indigo and Its Application for the Syntheses of Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-(6H)dione and -5-(6H)one Derivatives
  作者：Masanori Somei、Hiroyuki Hayashi、Tohru Izumi、Shinobu Ohmoto

  DOI：10.3987/com-95-7192

  日期：——

  Indigo was converted to 2,2'-bisindole, from which 6-substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-(6H)dione and -5-(6H)one derivatives were prepared in short steps. Bromination of 6-methylindolo[2,3-a]pyrrolo[3,4-c]carbazole5,7-(6H)dione is also reported.