ethyl 1-ethyl-6-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylate | 32953-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 1-ethyl-6-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylate
• 英文别名: 1-ethyl-6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester；Ethyl-1,4-dihydro-1-ethyl-6-methoxy-4-oxo-3-chinolincarboxlyat；1-Ethyl-6-methoxy-4-chinolon-3-carbonsaeure-ethylester；Ethyl 1-ethyl-6-methoxy-4-oxoquinoline-3-carboxylate
• CAS: 32953-38-1
• 化学式: C₁₅H₁₇NO₄
• 分子量: 275.304
• InChiKey: GGBREFQGSWQVOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 1-ethyl-6-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylate 在 一水合肼 作用下， 反应 2.0h， 以99%的产率得到1-Ethyl-6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrazide
  参考文献：
  名称：

  Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents

  摘要：

  The synthesis and in vivo activities of a series of substituted quinoline carboxyguanidines as a possible novel class of antidiabetic agents is described. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00354-1
• 作为产物：
  描述：

  甲氧苯胺 在 potassium carbonate 作用下， 以 二苯醚 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 ethyl 1-ethyl-6-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylate
  参考文献：
  名称：

  Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents

  摘要：

  The synthesis and in vivo activities of a series of substituted quinoline carboxyguanidines as a possible novel class of antidiabetic agents is described. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00354-1

文献信息

• N-alkylation of ethyl 1,4-dihydro-4-oxopyridine-3-carboxylates via their thallium(I) salts.
  作者：YASUMITSU TAMURA、MASANOBU FUJITA、LINGCHING CHEN、KYOJI UENO、YASUYUKI KITA

  DOI：10.1248/cpb.29.739

  日期：——

  Reaction of the thallium (I) salt of ethyl 1, 4-dihydro-4-oxopyridine-3-carboxylates with alkyl halides was shown to be a useful method for the regioselective N-alkylation of these compounds.

  1, 4-二氢-4-氧代吡啶-3-羧酸乙酯的铊 (I) 盐与烷基卤化物的反应被证明是对这些化合物进行区域选择性 N-烷基化的有效方法。
• Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents
  作者：Dolorès Edmont、Richard Rocher、Christophe Plisson、Jacques Chenault

  DOI：10.1016/s0960-894x(00)00354-1

  日期：2000.8

  The synthesis and in vivo activities of a series of substituted quinoline carboxyguanidines as a possible novel class of antidiabetic agents is described. (C) 2000 Elsevier Science Ltd. All rights reserved.