4-chloro-2-methoxyphenylmagnesium bromide, 0.50 m in thf | 1213256-49-5

• 物质功能分类: 化学试剂 - 格氏试剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-chloro-2-methoxyphenylmagnesium bromide, 0.50 m in thf
• CAS: 1213256-49-5
• 化学式: C₇H₆BrClMgO
• 分子量: 245.786
• InChiKey: GSPRMVLXEQJHIL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.99
• 重原子数：
  11.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  4-chloro-2-methoxyphenylmagnesium bromide, 0.50 m in thf 在 bis(norbornadiene)rhodium(l)tetrafluoroborate 、 (R,R)-1-[1-(di(t-butyl)phosphino)ethyl]-2-(diphenylphosphino)ferrocene 、 氢气 、 zinc trifluoromethanesulfonate 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 2-甲基四氢呋喃 、 甲苯 为溶剂， 50.0 ℃ 、300.01 kPa 条件下， 反应 37.0h， 生成 (S)-2-(4-chloro-2-methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1-(5-(trifluoromethoxy)-1H-indol-3-yl)ethanone
  参考文献：
  名称：

  [EN] PROCESSES FOR THE PREPARATION OF (S)-2-(4-CHLORO-2-METHOXYPHENYL)-2-((3-METHOXY-5-(METHYLSULFONYL)PHENYL)AMINO)-1 -(1H-INDOL-3-YL)ETHENONE DERIVATIVES
  [FR] PROCÉDÉS POUR LA PRÉPARATION DE DÉRIVÉS DE (S)-2-(4-CHLORO-2-MÉTHOXYPHÉNYL)-2-((3-MÉTHOXY-5-(MÉTHYLSULFONYL)PHÉNYL)AMINO)-1 -(1H-INDOL-3-YL)ÉTHÉNONE

  摘要：

  The present invention relates to a chiral synthesis of mono- or di-substituted (S)-2-(4-chloro-2-methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1-(1H-indol-3-yl)ethenone derivatives of formula (I) by a) reacting a 1-(4-chloro-2-methoxyphenyl)-2-(1H-indol-3-yl)ethane-1, 2-dione derivative of formula (II) with 3-methoxy-5-(methylsulfonyl)aniline to produce a 2-(4-chloro-2-methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl) phenyl)imino)-1-(1H-indol-3-yl)ethanone derivative of formula (II), and b) hydrogenation of this compound of formula (II) to produce the title compound of formula (I).

  公开号：

  WO2023274237A1
• 作为产物：
  描述：

  2-溴-5-氯苯甲醚 在 二异丁基氢化铝 、 magnesium 作用下， 以 四氢呋喃 为溶剂， 生成 4-chloro-2-methoxyphenylmagnesium bromide, 0.50 m in thf
  参考文献：
  名称：

  [EN] PROCESSES FOR THE PREPARATION OF (S)-2-(4-CHLORO-2-METHOXYPHENYL)-2-((3-METHOXY-5-(METHYLSULFONYL)PHENYL)AMINO)-1 -(1H-INDOL-3-YL)ETHENONE DERIVATIVES
  [FR] PROCÉDÉS POUR LA PRÉPARATION DE DÉRIVÉS DE (S)-2-(4-CHLORO-2-MÉTHOXYPHÉNYL)-2-((3-MÉTHOXY-5-(MÉTHYLSULFONYL)PHÉNYL)AMINO)-1 -(1H-INDOL-3-YL)ÉTHÉNONE

  摘要：

  The present invention relates to a chiral synthesis of mono- or di-substituted (S)-2-(4-chloro-2-methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1-(1H-indol-3-yl)ethenone derivatives of formula (I) by a) reacting a 1-(4-chloro-2-methoxyphenyl)-2-(1H-indol-3-yl)ethane-1, 2-dione derivative of formula (II) with 3-methoxy-5-(methylsulfonyl)aniline to produce a 2-(4-chloro-2-methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl) phenyl)imino)-1-(1H-indol-3-yl)ethanone derivative of formula (II), and b) hydrogenation of this compound of formula (II) to produce the title compound of formula (I).

  公开号：

  WO2023274237A1

文献信息

• [EN] MCL-1 MODULATING COMPOSITIONS<br/>[FR] COMPOSITIONS DE MODULATION DE MCL-1
  申请人：PENN STATE RES FOUND

  公开号：WO2013112878A1

  公开（公告）日：2013-08-01

  The present invention relates to marinopyrrole A derivatives and pyoluteorin derivatives and methods of treatment of disorders associated with misregulation of Mcl-l, e.g., leukemia, lymphoma, multiple myeloma, melanoma, or pancreatic cancer. We describe exemplary compounds, which may be contained in pharmaceutical compositions, and their use as therapeutic agents either alone or in combination with other anti-cancer treatments, e.g., anti-Bcl- 2 agents.

  本发明涉及海洋吡咯酮A衍生物和吡洛特霉素衍生物，以及治疗与Mcl-l误调节相关的疾病的方法，例如白血病、淋巴瘤、多发性骨髓瘤、黑色素瘤或胰腺癌。我们描述了一些示范性化合物，这些化合物可以包含在药物组合物中，并且它们可作为治疗剂单独使用或与其他抗癌治疗方法结合使用，例如抗Bcl-2剂。
• Compounds for inhibiting NLRP3 and uses thereof
  申请人：Ventus Therapeutics U.S., Inc.

  公开号：US11319319B1

  公开（公告）日：2022-05-03

  The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

  本公开涉及NLRP3抑制剂，用于治疗被该蛋白抑制的疾病和障碍，并具有公式（I）：
• Electronic Influences in Phosphinesulfonato Palladium(II) Polymerization Catalysts
  作者：Philipp Wucher、Verena Goldbach、Stefan Mecking

  DOI：10.1021/om400297x

  日期：2013.8.26

  To study the influence of electronics on catalytic polymerization properties independent from sterics, phosphinesulfonato Pd(II) complexes bearing remotely located substituents on the nonchelating P-bound aryls [kappa(2)-(P,O)-(4-R-2-anisyl)(2)PC6H4SO2O]Pd(Me)(dmso) (1ae-dmso: 1a, R = CF3; 1b, R = Cl; 1c, R = H; 1d, R = CH3; 1e, R = OCH3) were prepared. The electron-poor complex 1a-dmso (4-CF3) undergoes the fastest insertion of methyl acrylate (MA) and is the most active for ethylene polymerization. The polyethylene molecular weight increases by a factor of 2 for the more electron rich complex 1e-dmso (4-OCH3) (Mn = 17 x 10 (3) vs 8 x 10 (3) for 1a-dmso (4-CF3)). MA/ethylene copolymerization experiments revealed that the MA incorporation ratio and copolymer molecular weights are largely independent of the electronic nature of the remote substituents. These trends were further confirmed by studies of two mixed P-aryl/-alkyl complexes 1f-dmso ([kappa(2)-(2,4,6-(OMe)(3)C6H2)(tBu)PC6H4SO2O]Pd(Me)(dmso)) and 1g-dmso ([?2-(C6H5)(tBu)PC6H4SO2O]Pd(Me)(dmso)). In ethylene/MA copolymerization, 1f-dmso affords a significantly higher molecular weight polymer with reasonable MA incorporation (Mn = 12 x 10 (3) and 7.7 mol % MA) and activities similar to those observed for complexes 1ae-dmso.
• WO2024097629A1
  申请人：——

  公开号：——

  公开（公告）日：——
• US11618751
  申请人：——

  公开号：——

  公开（公告）日：——