Only 13 and 40 percent of the products excreted in urine and feces, respectively, are umetabolized Solvent Yellow 33. Therefore, a large fraction of the dye is metabolized, probably in the liver and kidney.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
副作用
职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/
/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/
/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
人类毒性摘录
/HUMAN EXPOSURE STUDIES/ 苯并咪唑颜料 D & C 黄色 No. 11 被添加到标准测试系列中。在用 1% 聚乙二醇 (PEG) 测试的 88 名患者中，有四名患者显示出无法解释的阳性测试反应。一名患者在 14 天后出现了“爆发”反应。在再次挑战时，他对稀释至 0.00001% 的颜料仍有反应。与化学上相关的常用食品色素喹啉黄 (E 104) 同时发生反应，表明存在交叉敏感性。
/HUMAN EXPOSURE STUDIES/ The quinoline color D & C Yellow No. 11 was added to a standard test series. Of 88 patients tested with 1% in PEG, four showed unexplained positive test reactions. One patient had a "flare-up" reaction after 14 days. At rechallenge he reacted to a dilution down to 0.00001%. Simultaneous reaction with the chemically related commonly used food color Quinoline Yellow (E 104) suggests cross-sensitivity.
/Investigators/ observed external color changes in Fischer 344 albino rats administered a single dose of 5,000 mg/kg of Solvent Yellow 33 or Solvent Yellow 33/Solvent Green 3 mixture by gavage. The color changes, which first appeared on day 2 after dosing, were observed throughout a 14-day observation period. The males were light green and the females were yellow. In the absence of vomiting, this observation indicates that the dyes may be excreted through the skin.
/Investigators/ exposed male F344/N rats to (14)C-solvent yellow aerosols (160 nmol solvent yellow/liter air) or a mixture of (14)C-solvent yellow and unlabeled solvent green (340 nmol solvent yellow and 370 nmol solvent green/liter air) for 60 min. After either exposure, solvent yellow was rapidly cleared from the respiratory tract, with a t1/2 of 2-3 hr. Solvent green was retained in the lungs with a minimum estimated t1/2 for clearance of 22 days. Solvent green was not detected in other tissues during the 70-hr post-exposure period. After either exposure, high-pressure liquid chromatography analysis of tissues extracts indicated that 40 to 75% of the (14)C in liver and kidney consisted of solvent yellow metabolites. Greater than 90% of the (14)C in the lungs was unmetabolized solvent yellow. The major pathway for excretion of solvent yellow and solvent yellow metabolites was the feces (74% of the initial body burden) ... Urinary (14)C accounted for 14% of the initial body burden ... Over 90% of the (14)C excreted in the urine was solvent yellow metabolites. Very little solvent yellow (2%) was metabolized to (14)CO2. By 72 hr after exposure, only 10% of the initial (14)C deposited remained in the body.
来源:Hazardous Substances Data Bank (HSDB)
吸收、分配和排泄
2-(2-喹啉基)-1,3-茚满二酮（D. C. 黄色 #11, DCY）在雄性Fischer大鼠体内的处置情况通过静脉注射或喂食进行了确定。对于通过饲料给予(14)C-DCY的大鼠（饲料的0.00044-0.41%），在24小时的给药期间和随后的72小时期间，粪便中放射性回收率从89.1%到93.9%，尿液中从4.98%到6.25%。组织中仅含有微量。在静脉注射(14)C-DCY（0.93 mg/kg）后，放射性物质容易分布到大多数组织中；在5分钟时，即最早的检测时间，存在最大量。然而，脂肪、皮肤和肠道组织中放射性物质的最大量出现在给药后30分钟。这三个组织的放射性物质消除的alpha阶段也相对较长。静脉给药后24小时内，大鼠在粪便中排泄了剂量的81.1%，在尿液中排泄了剂量的16.0%。对于安装了胆管插管的大鼠，4小时内胆汁中回收了剂量的54.5%，全部为(14)C-DCY的代谢物。与静脉给药的(14)C-DCY代谢物的快速和大量胆汁排泄相关的是粪便中大量放射性物质的出现，以及在中间时间点肝脏、肠道内容和肠道组织中的出现。总之，大鼠迅速分布、代谢和排泄(14)C-DCY。
The disposition of 2-(2-quinolyl)-1,3-indandione (D. C. yellow #11, DCY) in male Fischer rats dosed intravenously or by feeding was determined. For rats given (14)C-DCY in the feed (0.00044-0.41% of the diet), recovery of radioactivity during the 24-hr dosing period and the 72-hr period thereafter ranged from 89.1 to 93.9% for feces and from 4.98 to 6.25 for urine. Tissues contained only trace amounts. Following intravenous dosing with (14)C-DCY (0.93 mg/kg), radioactivity distributed readily into most tissues; maximum amounts were present at 5 min, the earliest time of assay. Maximum amounts of radioactivity in fat, skin, and gut tissue, however, were present at 30 min after dosing. These three tissues also had relatively long alpha phases for the elimination of radioactivity. In 24 hr after intravenous dosing, rats excreted 81.1% of the dose in the feces and 16.0% of the dose in the urine. For rats fitted with biliary cannulas, 54.5% of the dose, all of which was metabolites of (14)C-DCY, was recovered in the bile in 4 hr. Associated with the rapid and extensive biliary excretion of metabolites of intravenously administered (14)C-DCY was the appearance of large amounts of radioactivity in the feces and also, at intermediate time points, in the liver, gut contents, and gut tissue. In conclusion, rats rapidly distribute, metabolize, and excrete (14)C-DCY.
Solvent Yellow 33 is also rapidly absorbed from the lung after repeated exposures; less than 0.2 percent of the quantity deposited after each exposure is retained (i.e., 99.8 percent is absorbed within 16 hr).
[EN] OXIME ESTER PHOTOINITIATORS<br/>[FR] PHOTO-INITIATEURS À BASE D'ESTER D'OXIME
申请人：BASF SE
公开号：WO2021175855A1
公开（公告）日：2021-09-10
Disclosed are α-oxo oxime ester compounds based on carbazole derivatives which have specific substituent groups useful as a photoinitiator, as well as photopolymerizable compositions comprising said photoinitiator and ethylenically unsaturated compounds. The photopolymerizable compositions are useful, for example, in photoresist formulations for display applications, e.g. liquid crystal display (LCD), organic light emitting diode (OLED) and touch panel.
Method for manufacturing pigment dispersed liquid, and pigment dispersed liquid, and ink for ink-jet printer recording using said pigment dispersed liquid
申请人：SEIKO EPSON CORPORATION
公开号：US20020088375A1
公开（公告）日：2002-07-11
A method for manufacturing a pigment dispersed liquid, comprising at least:
Step A of introducing a hydrophilic dispersibility-imparting group directly and/or via another atomic group to the surface of pigment particles;
Step B of dispersing the pigment obtained in Step A in an aqueous medium; and
Step C of conducting refining treatment of the dispersed liquid obtained in Step B.
AQUEOUS CURABLE COMPOSITION AND WATER-SOLUBLE PHOTOPOLYMERIZATION INITIATOR
申请人：FUJIFILM CORPORATION
公开号：US20180362558A1
公开（公告）日：2018-12-20
An aqueous curable composition includes a water-soluble photopolymerization initiator having a structure in which one or more carbonyl groups further directly bond to an aromatic ring of an aromatic acyl group that bonds to a phosphorus atom in an acylphosphine oxide structure, water, and a polymerizable compound. A novel water-soluble photopolymerization initiator is a compound represented by formula 1-1 or formula 2-1.
The present invention relates to novel methine dyes, methods for the preparation thereof and use thereof for dyeing plastics, especially polyamides, so as to obtain yellow to orange colourings with improved light fastness and improved thermal stability.
NOVEL COMPOUND HAVING MULTIMER STRUCTURE OF XANTHENE DERIVATIVE, COLORING COMPOSITION, INK FOR INKJET RECORDING, METHOD OF INKJET RECORDING, COLOR FILTER, AND COLOR TONER
申请人：FUJIFILM CORPORATION
公开号：US20140176653A1
公开（公告）日：2014-06-26
There is provided a compound represented by formula (1):
in formula (1), L represents a divalent to tetravalent linking group; D represents a residue obtained by removing 1 to 5 hydrogen atoms from a compound represented by formula (2); m represents an integer of 1 to 10, however, each L may be the same with or different from every other L; n represents an integer of 2 to 10, however, each D may be the same with or different from every other D; and in formula (2), each of R
4
to R
24
independently represents a hydrogen atom or a substituent, provided that formula (2) has at least one or more ionic hydrophilic groups.
