（1α，1'R，4β）-4-甲氧基-5''-甲基-6'-[5-（1-丙炔基-1）-3-吡啶基]双螺[环己烷-1,2'-[2H]indene | 1383982-64-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: （1α，1'R，4β）-4-甲氧基-5''-甲基-6'-[5-（1-丙炔基-1）-3-吡啶基]双螺[环己烷-1,2'-[2H]indene
• 英文名称: Lanabecestat
• CAS: 1383982-64-6
• 化学式: C₂₆H₂₈N₄O
• 分子量: 412.5
• InChiKey: WKDNQONLGXOZRG-BOPKNSRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  72.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  、 [5-(丙炔-1-基)吡啶-3-基]硼酸 在 [5-(丙炔-1-基)吡啶-3-基]硼酸 作用下， 生成 （1α，1'R，4β）-4-甲氧基-5''-甲基-6'-[5-（1-丙炔基-1）-3-吡啶基]双螺[环己烷-1,2'-[2H]indene
  参考文献：
  名称：

  COMPOUNDS AND THEIR USE AS BACE INHIBITORS

  摘要：

  本发明涉及式（I）化合物及其制药组合物。此外，本发明还涉及用于治疗和/或预防与Aβ相关的病理学，例如唐氏综合症、β淀粉样蛋白病变（如但不限于脑淀粉样血管病变或遗传性脑出血）、与认知障碍相关的疾病（如但不限于轻度认知障碍）、阿尔茨海默病、记忆丧失、与阿尔茨海默病相关的注意力缺陷症状、与疾病相关的神经退行性疾病（如阿尔茨海默病或痴呆症，包括混合血管性和退行性起源的痴呆、早老性痴呆、老年性痴呆和与帕金森病、进行性核上性麻痹或皮质基底节变性相关的痴呆）。

  公开号：

  US20160184303A1

文献信息

• Camsylate Salt
  申请人：Bohlin Martin Hans

  公开号：US20140031379A1

  公开（公告）日：2014-01-30

  A camsylate salt of (1r,1′R,4R)-4-methoxy-5″-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3′H-dispiro[cyclohexane-1,2′-inden-1′2′-imidazole]-4″-amine, pharmaceutical compositions containing the salt and therapeutic uses of the salt for treating Aβ-related pathologies such as Alzheimer's Disease, Down's syndrome, β-amyloid angiopathy and conditions such as dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.

  一种(1r,1′R,4R)-4-甲氧基-5″-甲基-6′-[5-(丙炔基)吡啶-3-基]-3′H-二螺环[环己烷-1,2′-茚-1′2′-咪唑]-4″-胺的卡姆西酸盐，制药组合物包含该盐，以及该盐用于治疗与Aβ相关的病理学，如阿尔茨海默病、唐氏综合症、β-淀粉样蛋白血管病和痴呆等条件，包括混合性血管性和退行性起源的痴呆、早老性痴呆、老年性痴呆和与帕金森病、进行性核上性麻痹或皮质基底变性相关的痴呆的治疗用途。
• COMPOUNDS AND THEIR USE AS BACE INHIBITORS
  申请人：ASTRAZENECA AB

  公开号：US20160184303A1

  公开（公告）日：2016-06-30

  The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.

  本发明涉及式（I）化合物及其制药组合物。此外，本发明还涉及用于治疗和/或预防与Aβ相关的病理学，例如唐氏综合症、β淀粉样蛋白病变（如但不限于脑淀粉样血管病变或遗传性脑出血）、与认知障碍相关的疾病（如但不限于轻度认知障碍）、阿尔茨海默病、记忆丧失、与阿尔茨海默病相关的注意力缺陷症状、与疾病相关的神经退行性疾病（如阿尔茨海默病或痴呆症，包括混合血管性和退行性起源的痴呆、早老性痴呆、老年性痴呆和与帕金森病、进行性核上性麻痹或皮质基底节变性相关的痴呆）。
• COMBINATION THERAPY
  申请人：Eli Lilly and Company

  公开号：US20190038613A1

  公开（公告）日：2019-02-07

  The present invention provides a method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of (1r, 1′R,4R)-4-methoxy-5″-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3′H-dispiro[cyclohexane-1,2′-indene-1′,2″-imidazol]-4″-amine, or a pharmaceutically acceptable salt thereof (including the camsylate salt thereof); in combination with an effective amount of an anti-N3pGlu Abeta antibody.
• COMBINATION OF A BACE INHIBITOR AND AN ANTIBODY OR ANTIGEN-BINDING FRAGMENT FOR THE TREATMENT OF A DISORDER ASSOCIATED WITH THE ACCUMULATION OF AMYLOID BETA
  申请人：ASTRAZENECA AB

  公开号：US20190262327A1

  公开（公告）日：2019-08-29

  The present disclosure provides for methods for treating a subject having a disease or disorder associated with the accumulation of amyloid beta, comprising administering to the subject a BACE inhibitor and an antibody or antigen-binding fragment that binds to amyloid beta n-42. In some embodiments, the disease or disorder is Alzheimer's Disease.