雌三醇 3-硫酸酯 | 481-95-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 雌三醇 3-硫酸酯
• 中文别名: N-(吡啶-4-基)-2H-色烯-3-甲酰胺；雌三醇3-硫酸酯
• 英文名称: estriol-3-sulfate
• 英文别名: 16 alpha, 17 beta-Estriol-3-sulfate；estriol 3-sulfate；estriol sulfate；estriol-3-sulphate；[(8R,9S,13S,14S,16R,17R)-16,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate
• CAS: 481-95-8
• 化学式: C₁₈H₂₄O₆S
• 分子量: 368.451
• InChiKey: ZORQMBLUMWNJEQ-ZXXIGWHRSA-N

物化性质

• 密度：
  1.432±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  雌三醇 生成 雌三醇 3-硫酸酯
  参考文献：
  名称：

  Fex; Lundvall; Olsson, Acta Chemica Scandinavica (1947), 1968, vol. 22, # 1, p. 254 - 264

  摘要：

  DOI：

文献信息

• PROCESS FOR SELECTIVE SULFATION OF AROMATIC HYDROXYL GROUPS
  申请人：MEGATI Sreenivasulu

  公开号：US20080194533A1

  公开（公告）日：2008-08-14

  The present invention relates to processes for selective sulfation of an aromatic hydroxyl group over an aliphatic hydroxyl group where both are present in the same molecule. This invention also relates to processes for selective sulfation of the aromatic hydroxyl group of equilin, equilenin, estradiol, estra(1,3,5-triene)-3,16,17-triol, dihydroequilenin or dihydroequilin. This invention further relates to alkali metal salts of dihydroequilenin sulfates, dihydroequilin sulfates, estradiol sulfates, and estriol sulfates, processes for making thereof, stable compositions comprising thereof, and the use thereof.

  本发明涉及一种对同一分子中同时存在的芳香羟基和脂肪族羟基进行选择性磺酸化的方法。该发明还涉及对equilin、equilenin、雌二醇、雌三烯-3,16,17-三醇、二氢equilenin或二氢equilin的芳香羟基进行选择性磺酸化的方法。此外，该发明还涉及二氢equilenin磺酸盐、二氢equilin磺酸盐、雌二醇磺酸盐和雌三醇磺酸盐的碱金属盐、制备方法、稳定组合物及其用途。
• [EN] GPER PROTEOLYTIC TARGETING CHIMERAS<br/>[FR] CHIMÈRES DE CIBLAGE PROTÉOLYTIQUE GPER
  申请人：SALEM ALIASGER K

  公开号：WO2021217036A1

  公开（公告）日：2021-10-28

  A molecule comprising a G-protein coupled estrogen receptor (GPER) ligand coupled to a linker coupled to an E3 ubiquitin ligase ligand and methods of using the molecule are provided. In one embodiment, the GPER ligand is estradiol and the E3 ubiquitin ligase ligand is (S,R,S)- AHPC.

  提供了一种包含G蛋白偶联雌激素受体（GPER）配体、连接物和E3泛素连接酶配体的分子，以及使用该分子的方法。在一个实施例中，GPER配体是雌二醇，E3泛素连接酶配体是（S，R，S）-AHPC。
• Assay processes and materials therefor
  申请人：UNILEVER PLC

  公开号：EP0104926A2

  公开（公告）日：1984-04-04

  A process for carrying out a specific binding assay, for the qualitative detection or quantitative or semi-quantitative determination of an analyte which forms a component of a specific binding reaction, using a labelled conjugate form of a derivative or analogue of one of the relevant specific binding partners, said labelled form being capable of emitting delayed luminescence upon photo-excitation, characterised in that the labelled conjugate form of one of the relevant specific binding partners comprises a derivative or analogue of the specific binding partnerwith a derivative of a luminescent substance which shows a delayed light emission upon photoexcitation, the delayed light emission of which is subject to quenching by molecular oxygen, and characterised further in that the assay is carried out by the use of a time-resolved photometric method in the presence of an effective amount of a quench-inhibiting substance able to prevent quenching by molecular oxygen.

  一种进行特异性结合测定的工艺，用于定性检测或定量或半定量测定构成特异性结合反应成分的分析物，使用相关特异性结合伙伴之一的衍生物或类似物的标记共轭形式，所述标记形式在光激发时能够发出延迟发光、其特征在于，相关特异性结合剂之一的标记共轭形式包括该特异性结合剂的衍生物或类似物以及发光物质的衍生物，该发光物质在光激发时显示延迟发光，其延迟发光受分子氧淬灭的影响，其特征还在于，该检测是在存在有效量的淬灭抑制物质以防止分子氧淬灭的情况下，通过使用时间分辨光度法进行的。
• Imunoassay for estriol-3-sulfate
  申请人：NIHON MEDI-PHYSICS CO., LTD.

  公开号：EP0178683A1

  公开（公告）日：1986-04-23

  A process for producing an antibody having a specificity to estriol-3-sulfate, which comprises administering a 6- substituted-estriol-3-sulfate protein complex of the formula: wherein A is = N- O- or -O-CO-, n is an integer of 1 to 4 and NH - is the residue of a protein excluding a hydrogen atom in the amino form therefrom parenterally to a living body of a vertebrate animal so as to produce the antibody in the living body and collecting a body fluid comprising the antibody from the living body.

  一种生产对雌三醇-3-硫酸酯具有特异性的抗体的工艺，包括向脊椎动物的活体施用式中的 6-取代-雌三醇-3-硫酸酯蛋白质复合物，其中 A = N- O- 或-O-CO-，n 是 1 至 4 的整数，NH - 是蛋白质的残基，不包括其中氨基形式的氢原子，以便在活体中产生抗体，并从活体中收集包含抗体的体液。
• Total estriol fluorescence polarization immunoassay
  申请人：ABBOTT LABORATORIES

  公开号：EP0200960A1

  公开（公告）日：1986-11-12

  The present invention is directed to a homogeneous fluorescence polarization immunoassay for determining total estriol content in body fluids, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for preparing them. The assay is conducted by measuring the degree of polarization of plane polarized light that has been passed through a sample containing antiserum and tracer. The combination of antiserum and tracer used will possess excellent cross-reactivity to estriol-3-sulfate, eliminating the need for enzyme hydrolysis of this conjugate to free estriol.

  本发明涉及一种测定体液中总雌三醇含量的均相荧光偏振免疫测定法，涉及制备和进行这种测定所需的各种成分，以及制备这些成分的方法。 具体地说，本发明公开了示踪剂、免疫原和抗体，以及制备它们的方法。 该测定法是通过测量穿过含有抗血清和示踪剂的样品的平面偏振光的偏振程度来进行的。 所使用的抗血清和示踪剂的组合将对雌三醇-3-硫酸盐具有极好的交叉反应性，从而无需用酶水解这种共轭物来生成游离雌三醇。