ALA2(1,12-dodecanediol)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二硫杂环戊烷
• 英文名称: ALA2(1,12-dodecanediol)
• 英文别名: 12-[5-(Dithiolan-3-yl)pentanoyloxy]dodecyl 5-(dithiolan-3-yl)pentanoate
• 化学式: C₂₈H₅₀O₄S₄
• 分子量: 578.967
• InChiKey: FBUQKQDFKAUBLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  36
• 可旋转键数：
  25
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  154
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,12-十二烷二醇 、 Thioctic acid 在 4-吡咯烷基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 吡啶 为溶剂， 以71%的产率得到ALA2(1,12-dodecanediol)
  参考文献：
  名称：

  Self-assembled monolayers of bis-thioctic ester derivatives of oligoethyleneglycols: remarkable selectivity for K+/Na+ recognition

  摘要：

  通过循环伏安法和阻抗光谱法测量，寡甘醇的双硫代酸酯末端衍生物可在金电极上形成极其稳定的自组装单体（SAM），这些单体可选择性地识别 K+，而不是 Na+。

  DOI：

  10.1039/a905839g

文献信息

• [EN] ANTIOXIDANT CAMPTOTHECIN DERIVATIVES AND ANTIOXIDANT ANTINEOPLASTIC NANOSPHERES THEREOF<br/>[FR] DÉRIVÉS ANTIOXYDANTS DE LA CAMPTOTHÉCINE ET LEURS NANOSPHÈRES ANTIOXYDANTES ANTINÉOPLASIQUES
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2010060098A1

  公开（公告）日：2010-05-27

  The present invention is directed to antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs and the preparation of nanometer-sized camptothecin prodrugs. Methods of synthesizing the antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs, spontaneous emulsification or nanoprecipitation thereof to produce antioxidant camptothecin nanosphere prodrugs and their use in treating cancerous diseases are also provided. A further aspect of this invention is the use of these antioxidant camptothecin nanosphere prodrugs for the preparation of delivery devices of other pharmaceuticals and/or drugs.

  本发明涉及喜树碱的抗氧化衍生物、喜树碱类似物的抗氧化衍生物以及纳米级喜树碱前药的制备。还提供了合成喜树碱的抗氧化衍生物和喜树碱类似物的抗氧化衍生物的方法，以及通过自发乳化或纳米沉淀制备抗氧化喜树碱纳米球前药，并将其用于治疗癌症疾病的方法。本发明的另一个方面是利用这些抗氧化喜树碱纳米球前药制备其他药物的输送装置。
• [EN] NANOMETER-SIZED PRODRUGS OF NSAIDS<br/>[FR] PROMÉDICAMENTS DE DIMENSION NANOMÉTRIQUE DE NSAIDS
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2009148698A1

  公开（公告）日：2009-12-10

  The present invention describes nanoprodrugs of non-steroidal anti-inflammatory drug (NSAIDs) and nanoprodrugs of α-lipoic acid-containing and NSAIDs. These nanoprodrugs have antioxidant properties and stimuli-responsiveness, which can be used to treat various disease conditions.

  本发明描述了非甾体抗炎药（NSAIDs）的纳米前药和含α-硫辛酸和NSAIDs的纳米前药。这些纳米前药具有抗氧化性能和刺激响应性，可用于治疗各种疾病情况。
• [EN] ANTIOXIDANT, NEUROPROTECTIVE AND ANTINEOPLASTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT ON AN AMPHIPHILIC SPACER OR AN AMPHIPHILIC POLYMER<br/>[FR] NANOPARTICULES ANTIOXYDANTES, NEUROPROTECTRICES ET ANTINÉOPLASIQUES COMPRENANT UN AGENT THÉRAPEUTIQUE SUR UN ESPACEUR AMPHIPHILE OU UN POLYMÈRE AMPHIPHILE
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2013016696A1

  公开（公告）日：2013-01-31

  This invention relates to antioxidant, neuroprotective and antineoplastic nanoparticles comprising a therapeutic agent on an amphiphilic spacer or an amphiphilic polymer. Methods of synthesizing the antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs, NSAIDs and statins, spontaneous emulsification or nanoprecipitation thereof to produce antioxidant, neuroprotective and anti-neoplastic nanoparticles comprising a therapeutic agent on an amphiphilic spacer or an amphiphilic polymer and their use in treating cancerous diseases are also provided. A further aspect of this invention is the use of these neuroprotective and anti-neoplastic nanoparticles for the preparation of delivery devices of other pharmaceuticals and/or drugs.

  本发明涉及抗氧化剂、神经保护剂和抗肿瘤纳米粒子，其包括具有治疗剂的两性亲脂间隔物或两性亲脂聚合物。还提供了合成伯氨替芬的抗氧化剂衍生物和伯氨替芬类似物、NSAIDs和他汀类药物的抗氧化剂衍生物的方法，以及通过自发乳化或纳米沉淀制备这些抗氧化、神经保护和抗肿瘤纳米粒子，其包括具有治疗剂的两性亲脂间隔物或两性亲脂聚合物，并且它们在治疗癌症疾病中的应用。本发明的另一个方面是利用这些神经保护和抗肿瘤纳米粒子制备其他药物和/或药物的输送装置。
• Self-assembled monolayers of bis-thioctic ester derivatives of oligoethyleneglycols: remarkable selectivity for K+/Na+ recognition
  作者：Krisanu Bandyopadhyay、Haiying Liu、Sheng-Gao Liu、Luis Echegoyen

  DOI：10.1039/a905839g

  日期：——

  Bis-thioctic ester terminated derivatives of oligoethylene glycols form extremely stable self-assembled monlayers (SAMs) on gold electrodes and these can recognize K+ selectively over Na+, as measured by cyclic voltammetry and impedance spectroscopy.

  通过循环伏安法和阻抗光谱法测量，寡甘醇的双硫代酸酯末端衍生物可在金电极上形成极其稳定的自组装单体（SAM），这些单体可选择性地识别 K+，而不是 Na+。
• Ion Recognition at the Interface of Self-Assembled Monolayers (SAMs) of Bis-Thioctic Ester Derivatives of Oligo(ethyleneglycols)
  作者：Krisanu Bandyopadhyay、Sheng-Gao Liu、Haiying Liu、Luis Echegoyen

  DOI：10.1002/1521-3765(20001201)6:23<4385::aid-chem4385>3.3.co;2-z

  日期：2000.12.1

  corresponding SAMs showed ion binding properties and selectivities similar to those exhibited by 15-crown-5 or 18-crown-6 in aqueous solution, respectively. Impedance data for the SAMs as a function of metal ion concentrations were fitted by using a Langmuir isotherm to determine the association constants (Ka) with the different ions. The SAM derived from the n = 5 compound is selective for Na+ while

  制备了低聚乙二醇的双硫辛酸酯衍生物的自组装单分子膜（SAMs）。当这些Podand中的（-CH2-CH2-O-）n单元数为5或6时，相应的SAMs的离子键合性质和选择性类似于在15-cro-5或18-cro-6中显示的离子结合性质和选择性。水溶液。通过使用Langmuir等温线确定与不同离子的缔合常数（Ka），拟合了SAMs的阻抗数据作为金属离子浓度的函数。衍生自n = 5化合物的SAM对Na +具有选择性，而具有n = 6的SAM对K +具有选择性。本文提供的结果证实了在金表面上无环聚乙二醇衍生物的自组装过程中离子识别域的形成。