(11-巯基十一烷基)六(乙二醇) | 130727-44-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (11-巯基十一烷基)六(乙二醇)
• 英文名称: (1-mercaptoundec-11-yl)hexa(ethylene glycol)
• 英文别名: (11-mercaptoundecyl)hexa(ethylene glycol)；HS-(CH2)11-(EG)6-OH；29-Sulfanyl-3,6,9,12,15,18-hexaoxanonacosan-1-ol；2-[2-[2-[2-[2-[2-(11-sulfanylundecoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
• CAS: 130727-44-5
• 化学式: C₂₃H₄₈O₇S
• 分子量: 468.696
• InChiKey: QYKSUHRPPSCIFK-UHFFFAOYSA-N

物化性质

• 沸点：
  550.4±45.0 °C(Predicted)
• 密度：
  1.0154 g/mL at 25 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  31
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  76.6
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• WGK Germany：
  3
• 储存条件：
  2-8°C，存放在密封且干燥的环境中。

制备方法与用途

Thiol-C9-PEG7 是一种PROTAC连接子，属于PEG类化合物，可以用于合成PROTAC分子。

反应信息

• 作为反应物：
  描述：

  (11-巯基十一烷基)六(乙二醇) 、 三苯基氯甲烷 在 crude residue 、 乙酸乙酯 、 甲醇乙酸乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以to afford 910 mg (49%) of 4的产率得到2-{2-[2-(2-{2-[2-(11-Tritylsulfanyl-undecyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol
  参考文献：
  名称：

  Peelable and resealable devices for biochemical assays

  摘要：

  本发明提供了用于对材料进行测定的装置和方法，特别是生物材料。该装置和方法利用自封闭成员，可以应用于平面表面上形成井，以便在平面表面上固定材料，然后移除以产生平面表面，以便于在固定的材料上进行处理和/或检测。

  公开号：

  US07371563B2
• 作为产物：
  描述：

  六甘醇 在 盐酸 、 sodium hydroxide 、 偶氮二异丁腈 作用下， 以 甲醇 为溶剂， 反应 34.0h， 生成 (11-巯基十一烷基)六(乙二醇)
  参考文献：
  名称：

  Formation of self-assembled monolayers by chemisorption of derivatives of oligo(ethylene glycol) of structure HS(CH2)11(OCH2CH2)mOH on gold

  摘要：

  This paper describes the preparation of oligo(ethylene glycol)-terminated alkanethiols having structure HS-(CH2)11(OCH2CH)m(OH) (m = 3-7) and their use in their use in the formation of self-assembled monolayers (SAMs) on gold. A combination of experimental evidence derived from X-ray photoelectron spectroscopy (XPS), measurement of contact angles, and ellipsometry implies substantial disorder in the oligo(ethylene glycol)-containing segment. The order in the -(CH2)11-group is not defined by the available evidence. The SAMs are moderately hydrophilic: theta-a(H2O) = 34-38-degrees; theta-r(H2O) = 22-25-degrees. A study of monolayers containing mixtures of HS(CH2)11CH3 and HS(CH2)11(OCH2CH2)6OH suggests that the oligo(ethylene glycol) moieties are effective at preventing underlying methylene groups from influencing wetting by water. A limited study demonstrates that these oligo(ethylene glycol)-containing SAMs resist that adsorption of protein from solution and suggests that SAMS will be a useful model system model for studying the adsorption of proteins onto organic surfaces.

  DOI：

  10.1021/ja00001a002

文献信息

• Sensor surfaces for detecting analytes
  申请人：Prolinx Incorporated

  公开号：US20020192722A1

  公开（公告）日：2002-12-19

  The present invention provides a sensor surface comprising: a substrate coated with a free electron metal; and a matrix layer disposed on the free electron metal, wherein the matrix layer comprises an organic compound having a boronic acid complexing moiety. The matrix is preferably a self-assembled monolayer (SAM), a mixed self-assembled monolayer (mSAM), or combinations thereof.

  本发明提供了一种传感器表面，包括：涂有自由电子金属的基板；以及位于自由电子金属上的基质层，其中基质层包括具有硼酸络合基团的有机化合物。该基质最好是自组装单分子层(SAM)、混合自组装单分子层(mSAM)或它们的组合。
• METHODS OF DETECTING IMMOBILIZED BIOMOLECULES
  申请人：Duffy David

  公开号：US20050100974A1

  公开（公告）日：2005-05-12

  Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.

  提供了用于对材料进行测定的装置和方法，特别是生物材料。这些装置和方法利用自封闭成员，可以应用于平面表面上形成孔以促进材料在平面表面上的固定，然后将其移除以得到一个平面表面，以便对固定材料进行处理和/或检测。
• METHODS OF ARRAYING BIOLOGICAL MATERIALS USING PEELABLE AND RESEALABLE DEVICES
  申请人：Duffy David

  公开号：US20050250097A1

  公开（公告）日：2005-11-10

  Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.

  提供用于对材料进行测定的装置和方法，特别是用于生物材料的测定。这些装置和方法利用自封闭成员，可以应用于平面表面上形成孔以便于将材料固定在平面表面上，然后移除以得到一个平面表面，以便于对固定材料进行处理和/或检测。
• Methods of measuring enzyme activity using peelable and resealable devices
  申请人：——

  公开号：US20030032076A1

  公开（公告）日：2003-02-13

  Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.

  本发明提供了用于对材料进行测定的装置和方法，特别是生物材料。该装置和方法利用自密封成员，可以应用于平面表面上形成孔以便于将材料固定在平面表面上，然后移除以产生平面表面，以便于在固定的材料上执行过程和/或检测。
• Sensor surfaces for detecting analytes and methods of use
  申请人：Prolinx Incorporated

  公开号：US20030032202A1

  公开（公告）日：2003-02-13

  The present invention provides a method for detecting an analyte, comprising providing a sensor comprising a substrate coated with a free electron metal, a matrix layer disposed on the free electron metal, the matrix layer comprising an organic compound, wherein the organic compound has a boronic acid complexing moiety and, a boronic acid moiety complexed to the boronic acid complexing moiety; and contacting the sensor with the analyte to elicit a response; and measuring the response thereby detecting the analyte.

  本发明提供了一种检测分析物的方法，包括提供一个传感器，该传感器包括涂有自由电子金属的基板，放置在自由电子金属上的基质层，该基质层包括一种有硼酸络合基团的有机化合物，其中硼酸络合基团与硼酸基团络合；将传感器与分析物接触以引发响应；并通过测量响应来检测分析物。