4-氟-2-硝基苯甲醛 | 2923-96-8

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氟-2-硝基苯甲醛
• 中文别名: 2-硝基-4-氟苯甲醛
• 英文名称: 4-fluoro-2-nitrobenzaldehyde
• CAS: 2923-96-8
• 化学式: C₇H₄FNO₃
• 分子量: 169.112
• InChiKey: ORCGMGUNVGVHDN-UHFFFAOYSA-N

物化性质

• 熔点：
  32-33 °C
• 沸点：
  294.2±25.0 °C(Predicted)
• 密度：
  1.443±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2913000090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335
• 储存条件：
  室温，惰性气体

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
4-Fluoro-2-nitrobenzaldehyde
Product Name:
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
Wear protective gloves/protective clothing/eye protection/face protection
P280:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405: Store locked up

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Section 3. Composition/information on ingredients.
4-Fluoro-2-nitrobenzaldehyde
Ingredient name:
CAS number: 2923-96-8

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Section 4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Not specified
Appearance:
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C7H4FNO3
Molecular weight: 169.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-氟-2-硝基苯甲醛 在 甲醇 、 sodium 、 一水合肼 、 溶剂黄146 、 三氯化磷 作用下， 以 氯仿 为溶剂， 反应 19.0h， 生成 7-fluoro-4-hydroxy-1-oxo-1,2-dihydropyridazino[4,5-b]quinoline
  参考文献：
  名称：

  环状酰肼

  摘要：

  DOI：

  10.1007/bf02290617
• 作为产物：
  描述：

  对氟甲苯 在 chromium(VI) oxide 、 硫酸 、 硝酸 、 乙酸酐 作用下， 生成 4-氟-2-硝基苯甲醛
  参考文献：
  名称：

  Bentov,M. et al., Journal of the Chemical Society, 1962, p. 2825 - 2827

  摘要：

  DOI：

文献信息

• FURTHER SUBSTITUTED TRIAZOLO QUINOXALINE DERIVATIVES
  申请人：Grünenthal GmbH

  公开号：US20200024281A1

  公开（公告）日：2020-01-23

  The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

  本发明涉及符合一般式(I)的化合物，这些化合物作为糖皮质激素受体的调节剂，并可用于治疗和/或预防至少部分由糖皮质激素受体介导的疾病。
• Benzoxazepinones and their use as squalene synthase inhibitors
  申请人：——

  公开号：US20030078251A1

  公开（公告）日：2003-04-24

  There is disclosed a compound represented by the formula [I]: 1 wherein R 1 is optionally substituted 1-carboxyethyl group, optionally substituted alkyl-sulfonyl group, optionally substituted (carboxy-cycloalkyl)-alkyl group, —X 1 —X 2 —Ar—X 3 —X 4 —COOH (wherein X 1 and X 4 are a bond or alkylene group, X 2 and X 3 are a bond, —O—, —S—, Ar is divalent aromatic group etc.), R 2 is alkyl group optionally substituted with alkanoyloxy group and/or hydroxy group, R 3 is alkyl group, and W is halogen atom, etc., or a salt thereof. The compound has the cholesterol lowering activity and the triglyceride lowering activity and is useful for preventing and/or treating hyperlipidemia.

  披露了一种由公式[I]表示的化合物： 1 其中R 1 是可选地取代的1-羧乙基，可选地取代的烷基亚磺酰基，可选地取代的(羧基环烷基)-烷基，—X 1 —X 2 —Ar—X 3 —X 4 —COOH(其中X 1 和X 4 是键或亚烷基，X 2 和X 3 是键，—O—，—S—，Ar是二价芳香族等)，R 2 是可选地由酰氧基和/或羟基取代的烷基，R 3 是烷基，W是卤素原子等，或其盐。该化合物具有降低胆固醇活性和降低甘油三酯活性，用于预防或治疗高脂血症。
• Palladium-catalyzed carbonylative cyclization of benzyl chlorides with anthranils for the synthesis of 3-arylquinolin-2(1<i>H</i>)-ones
  作者：Jian-Li Liu、Ren-Rui Xu、Wei Wang、Xinxin Qi、Xiao-Feng Wu

  DOI：10.1039/d1ob00298h

  日期：——

  An efficient carbonylative procedure for the synthesis of 3-arylquinoin-2(1H)-ones has been established. Through a palladium-catalyzed aminocarbonylation of benzyl chlorides with anthranils, a variety of 3-arylquinoin-2(1H)-one products were obtained in moderate to excellent yields with good functional group tolerance.

  已经建立了用于合成 3-arylquinoin-2(1 H )-ones 的有效羰基化方法。通过钯催化的苄基氯与邻氨基苯甲酰氨基羰基化反应，以中等至优异的收率获得了多种 3-arylquinoin-2(1 H )-one 产物，具有良好的官能团耐受性。
• Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol‐Inspired Compound Collection
  作者：Thomas Whitmarsh‐Everiss、Asger Hegelund Olsen、Luca Laraia

  DOI：10.1002/anie.202111639

  日期：2021.12.13

  A general strategy for the identification of selective cholesterol transport protein inhibitors through the synthesis of a diverse sterol-inspired compound collection is presented. Fusion of a primary sterol scaffold to diverse secondary natural product-derived scaffolds afforded hits against all of the Aster family of cholesterol transport proteins and selective inhibitors of Aster-C.

  介绍了通过合成多种甾醇化合物集合来鉴定选择性胆固醇转运蛋白抑制剂的一般策略。初级甾醇支架与多种次级天然产物衍生支架的融合提供了针对胆固醇转运蛋白的所有 Aster 家族和 Aster-C 的选择性抑制剂的攻击。
• Repurposing an Aldolase for the Chemoenzymatic Synthesis of Substituted Quinolines
  作者：Douglas J. Fansher、Richard Granger、Satinderpal Kaur、David R. J. Palmer

  DOI：10.1021/acscatal.1c01398

  日期：2021.6.18

  Quinoline derivatives are important natural products and pharmaceuticals, but their synthesis can be challenging due to poor yields, harsh reaction conditions, and instability of starting materials. Here we report the chemoenzymatic synthesis of quinaldic acids under mild conditions using an aldolase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (NahE, or HBPA). A series of 2-aminobenzaldehydes

  喹啉衍生物是重要的天然产物和药物，但由于收率低、反应条件苛刻和起始材料不稳定，它们的合成具有挑战性。在这里，我们报告了使用醛缩酶、反式-o-羟基亚苄基丙酮酸水合酶-醛缩酶（NahE 或 HBPA）在温和条件下化学酶法合成喹哪二酸。在 NahE 存在下，一系列源自相应硝基类似物还原的 2-氨基苯甲醛与丙酮酸反应，以高达 93% 的分离产率得到取代的喹啉。该反应不同于体内NahE 催化的羟醛缩合，而是类似于由其同源物二氢吡啶二羧酸合酶催化的杂环形成。

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