奎尼酸 | 562-73-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 奎尼酸
• 英文名称: 1,3,4,5-tetrahydroxy-cyclohexanecarboxylic acid
• 英文别名: 1,3,4,5-tetrahydroxy-1-cyclohexanecarboxylic acid；1,3,4,5-tetrahydroxycyclohexanecarboxylic acid；quinic acid；1,3,4,5-Tetrahydroxy-cyclohexancarbonsaeure；Cyclohexantetrol-(1.3.4.5)-carbonsaeure-(1)；Chinasaeure；1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid
• CAS: 562-73-2
• 化学式: C₇H₁₂O₆
• mdl: MFCD00065351
• 分子量: 192.169
• InChiKey: AAWZDTNXLSGCEK-UHFFFAOYSA-N

物化性质

• 沸点：
  438.4±45.0 °C(Predicted)
• 密度：
  1.828±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  奎尼酸 生成 苯
  参考文献：
  名称：

  Woehler, Justus Liebigs Annalen der Chemie, 1844, vol. 51, p. 146

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 奎尼酸 、 阿曲库铵杂质N
  参考文献：
  名称：

  Gadamer; Knoch, Archiv der Pharmazie, 1921, vol. 259, p. 149

  摘要：

  DOI：

文献信息

• Water Soluble and Activable Phenolics Derivatives with Dermocosmetic and Therapeutic Applications and Process for Preparing Said Derivatives
  申请人：Auriol Daniel

  公开号：US20090233876A1

  公开（公告）日：2009-09-17

  The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-α-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrhythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic antimutagenic, antineoplastic, anti-thrombotic, and vasodilatory formulations, or in any other field of application.

  该发明涉及通过酶催化将选择自间苯二酚或其衍生物的酚类与蔗糖的葡萄糖部分进行缩合来制备酚类衍生物。所述酚类衍生物的生产是通过葡萄糖转移酶（EC 2.4.1.5）实现的。所选酚类的这些O-α-葡糖苷是新的，其在水中的溶解度高于它们的原始多酚，并且在化妆品和药用组合物中具有有用的应用，如抗氧化、抗病毒、抗菌、免疫刺激、抗过敏、降压、抗缺血、抗心律失常、抗血栓形成、降胆固醇、抗脂质过氧化、肝脏保护、抗炎症、抗癌变突变、抗肿瘤、抗血栓形成和扩血管等配方，或者在任何其他应用领域中。
• pH-Specific synthesis, spectroscopic, structural and magnetic, and aqueous solution studies in the binary Cr(III)–quinato system
  作者：C. Mateescu、C. Gabriel、C.P. Raptopoulou、A. Terzis、V. Tangoulis、A. Salifoglou

  DOI：10.1016/j.poly.2012.08.005

  日期：2013.3

  elemental analysis, spectroscopic (UV–Vis, FT-IR, ESI-MS, EPR), structural, thermal, cyclic voltammetric, and magnetic susceptibility studies. The collective structural and spectroscopic techniques point out the distinct properties of 1 in the solid state and in solution, thus exemplifying the physicochemical profile of that compound in the overall structural speciation scheme of the binary Cr(III)–quinato

  摘要铬广泛存在于环境中，并在非生物和生物系统的大量工业应用中使用。它通过与生物分子的相互作用影响生物过程的能力强调了它的积极作用以及它在高等生物中的毒性表现。为了理解其（生物）化学，进行了研究工作，以探索具有低分子量生理配体奎宁酸的Cr（III）的水化学。在二元Cr（III）-奎纳多体系中特定于pH的合成导致Na [Cr3O（C7H11O6）6（H2O）3]·（NO3）1.5·（OH）0.5·6H2O的分离（1）。1在单斜空间群C2中结晶，a = 32.16（1）A，b = 14.076（7）A，c = 15.083（5）A，β= 95.53（1）°，V = 6796（5）A3， Z =4。结构1揭示了Cr（III）与奎宁酸盐的三核组装体。该组件由一个[Cr3O]核组成，该核包含将三个Cr（III）离子保持在一起的三键结合的氧化O2-配体和六个以外围循环方式连续连接三个Cr（III）中心的
• Method for binding, in solution, a peptide and a lipophilic vector and uses thereof
  申请人：——

  公开号：US20040092015A1

  公开（公告）日：2004-05-13

  The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, said coupling comprising a step which consists in producing a hydrazone bond between said peptide compound and said lipophilic vector. The invention also concerns lipophilic vectors for use in said method, lipopeptides obtained by said method, uses of said lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.

  本发明涉及一种方法，用于在溶液中结合至少一种肽组分和至少一种带有醛功能的亲脂性载体，该偶联包括一步，其中包括在所述肽化合物和所述亲脂性载体之间产生一个肼酮键。本发明还涉及用于该方法的亲脂性载体，通过该方法获得的脂肽，以及用于细胞筛选的所述脂肽的用途，以及本发明的应用，特别是通过生理屏障（如细胞膜）来制备靶向肽类活性原理（例如激素或神经肽）的方法。
• Vitamin D Receptor Agonists and Uses Thereof
  申请人：Kawai Megumi

  公开号：US20120115824A1

  公开（公告）日：2012-05-10

  Disclosed is a compound of Formula (I) in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, and a are defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are a pharmaceutical composition comprising a compound or salt thereof of Formula (I) and a method of treating a disease which benefits from the modulation of the vitamin D receptor, such as a bone disorder, cardiovascular disease, a cardiovascular complication associated with renal disease, endothelial dysfunction, hyperparathyroidism, hypocalcemia, an immune disorder, left ventricular hypertrophy, a proliferative disease, proteinuria, renal disease, and thrombosis.

  本发明公开了一种式（I）的化合物，其中R1、R2、R3、R4、R5、R6、X和a如本文所定义，或其药学上可接受的盐。本发明还公开了一种包括式（I）的化合物或其盐的制药组合物，以及一种治疗需要调节维生素D受体的疾病的方法，例如骨疾病、心血管疾病、与肾脏疾病相关的心血管并发症、内皮功能障碍、甲状旁腺功能亢进、低钙血症、免疫紊乱、左心室肥厚、增生性疾病、蛋白尿、肾脏疾病和血栓形成等疾病。
• Bioavailability and improved delivery of alkaline pharmaceutical drugs
  申请人：——

  公开号：US20040214215A1

  公开（公告）日：2004-10-28

  Embodiments of the invention relate to a composition, a process of making the composition, and to the use of the composition. The compositions include a molecular complex formed between an alkaline pharmaceutical drug and at least one selected from a hydroxyacid, a polyhydroxy acid, a related acid, a lactone, or combinations thereof. The compositions provide improved bioavailability and improved delivery of the drug into the cutaneous tissues.

  本发明实施例涉及一种组合物、制备该组合物的过程以及使用该组合物。该组合物包括碱性药物和至少一种选择自羟酸、多羟酸、相关酸、内酯或其组合物的分子复合物。该组合物提供了改善的生物利用度和将药物输送至皮肤组织的改善输送。

表征谱图