(S)-6-(tert-butyloxycarbonyl)-1,2,6-triaminohexane | 175660-27-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-6-(tert-butyloxycarbonyl)-1,2,6-triaminohexane
• 英文别名: S-6-N-tert-butyloxycarbonyl-1,2,6-triaminohexane；(S)-tert-butyl (5,6-diaminohexyl)carbamate；tert-butyl N-[(5S)-5,6-diaminohexyl]carbamate
• CAS: 175660-27-2
• 化学式: C₁₁H₂₅N₃O₂
• 分子量: 231.338
• InChiKey: QYOJETPEEKPPLJ-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  90.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-6-(tert-butyloxycarbonyl)-1,2,6-triaminohexane 在 草酰氯 、 potassium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 6-[[(2S)-2-[(5-carboxy-6-oxo-1-phenylmethoxypyridine-2-carbonyl)amino]-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexyl]carbamoyl]-2-oxo-1-phenylmethoxypyridine-3-carboxylic acid
  参考文献：
  名称：

  [EN] THIOHYDROXYPYRIDINE CHELATES
  [FR] CHÉLATES DE THIOHYDROXYPYRIDINE

  摘要：

  提供了一种金属离子螯合剂，能够稳定地结合软路易斯酸金属离子，基于这些螯合剂的金属离子螯合物，并且提供了使用该发明中化合物进行诊断和治疗方法的方法。还提供了隔离软路易斯酸金属离子的方法。软路易斯酸金属离子的示例是放射性核素。

  公开号：

  WO2022087317A1
• 作为产物：
  描述：

  Nε-Boc-Nα-Cbz-L-赖氨酸 在 镍 氨 、 氢气 、 氯甲酸乙酯 、 三乙胺 、 三氟乙酸酐 作用下， 以 四氢呋喃 、 甲醇 为溶剂， -10.0~50.0 ℃ 、5.07 MPa 条件下， 反应 27.75h， 生成 (S)-6-(tert-butyloxycarbonyl)-1,2,6-triaminohexane
  参考文献：
  名称：

  Salen-anthraquinone Conjugates. Synthesis, DNA-binding and cleaving properties, effects on topoisomerases and cytotoxicity

  摘要：

  A series of amidoethylamino-anthraquinone derivatives bearing either one or two salen (bis(salicylidene)ethylenediamine) moieties complexed with Cu-II or Ni-II have been synthesized, and their DNA-binding and cleaving properties examined. The effects of the mono- and di-substituted anthracenedione-salen conjugates on DNA cleavage mediated by topoisomerases I and II have also been determined, as well as their cytotoxicity toward human KB cells. The anthraquinone-salen . Ni-II conjugates bind to CC-rich sequences in DNA, but do not cleave the macromolecule. By contrast, the anthraquinone-salen . Cu-II hybrids do not recognize particular nucleotide sequences but efficiently induce single-strand breaks in DNA after activation. The 5,8-dihydroxy-anthraquinone conjugates are more cytotoxic and more potent toward topoisomerase II than the non-hydroxylated analogues, but they are less cytotoxic than the salen-free anthraquinones. The attachment of a salen . Cu-II complex to the anthra quinone chromophore can confer DNA cleaving properties in vitro, but this is at the expense of cytotoxic activity. Anthraquinone-salen . Cu-II complexes may find useful employ as footprinting probes for investigating ligand-DNA interactions. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0968-0896(96)00082-x

文献信息

• [EN] MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF<br/>[FR] LIGANDS MACROCYCLIQUES AYANT DES FRACTIONS CHÉLATANTES PENDANTES ET LEURS COMPLEXES
  申请人：LUMIPHORE INC

  公开号：WO2019173639A1

  公开（公告）日：2019-09-12

  The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.

  这项发明涉及与金属离子形成的配体和配合物，在各种应用中有用，包括治疗和诊断应用。
• Macrocyclic ligands with pendant chelating moieties and complexes thereof
  申请人：LUMIPHORE, INC.

  公开号：US10239878B2

  公开（公告）日：2019-03-26

  The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.

  本发明涉及配体和金属离子与配体的络合物，可用于各种应用，包括治疗和诊断应用。
• A Ni(Salen)-Biotin Conjugate for Rapid Isolation of Accessible DNA
  作者：Xiang Zhou、Jason Shearer、Steven E. Rokita

  DOI：10.1021/ja0018670

  日期：2000.9.1
• Synthesis of a Functionalized Salen−Copper Complex and Its Interaction with DNA
  作者：Sylvain Routier、Jean-Luc Bernier、Michael J. Waring、Pierre Colson、Claude Houssier、Christian Bailly

  DOI：10.1021/jo951840c

  日期：1996.1.1

  An original procedure for efficient synthesis of a functionalized salen copper complex is reported. The mode of binding to DNA of the salen . Cu-II complex was investigated by viscometry as well as by absorption, circular, and linear dichroism spectroscopy. The complex can induce DNA strand breakage in the presence of a reducing agent as revealed by a plasmid cleavage assay. The spectroscopic and biochemical data indicate that the salen . Cu-II complex induces single-stranded breaks via an interaction within one of the grooves of the double helix.
• Highly preferential cleavage of unpaired guanines in DNA by a functionalized salen-nickel complex
  作者：Sylvain Routier、Jean-Luc Bernier、Jean-Pierre Catteau、Christian Bailly

  DOI：10.1016/s0960-894x(96)00569-0

  日期：1997.1

  In the presence of oxygen donnor compounds, a functionalized salen-nickel complex poorly cuts double-stranded DNA but induces strong cleavages at guanine residues in the single-stranded region of hairpin oligonucleotides. Copyright (C) 1996 Elsevier Science Ltd