7,4',7'',4'''-tetra-O-methylamentoflavone | 22783-08-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7,4',7'',4'''-tetra-O-methylamentoflavone
• 英文别名: amentoflavone 7,7'',4',4'''-tetramethyl ether；7''-O-Methylsciadopitysin；5-hydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-7-methoxy-2-(4-methoxyphenyl)chromen-4-one
• CAS: 22783-08-0
• 化学式: C₃₄H₂₆O₁₀
• 分子量: 594.574
• InChiKey: VXQYICLHHMETFH-UHFFFAOYSA-N

物化性质

• 沸点：
  813.5±65.0 °C(Predicted)
• 密度：
  1.391±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  44
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  7,4',7'',4'''-tetra-O-methylamentoflavone 在 sodium hydride 、 sodium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 mineral oil 为溶剂， 反应 1.08h， 生成
  参考文献：
  名称：

  水溶性异银杏素-磷酸类似物的生物学研究，靶向具有体内抗肿瘤活性的剪接体

  摘要：

  本文报道了天然产物异银杏素以及四种水溶性异银杏素-磷酸类似物的首次全合成。此外，本文公开了IP2磷酸类似物在药理学特性（代谢和血浆稳定性、药代动力学、脱靶等）以及体外和体内生物活性方面的全面研究。

  DOI：

  10.1021/acs.jmedchem.1c01654
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 potassium carbonate 、 丙酮 、 碘甲烷 作用下， 生成 7,4',7'',4'''-tetra-O-methylamentoflavone
  参考文献：
  名称：

  Nakazawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1941, vol. 61, p. 174,178, 183, 228; dtsch. Ref. Nr. 6, S. 72, 90

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS, COMPOSITION AND USES THEREOF FOR TREATING CANCER<br/>[FR] COMPOSÉS, COMPOSITION ET LEURS UTILISATIONS DANS LE TRAITEMENT DU CANCER
  申请人：ROUSSY INST GUSTAVE

  公开号：WO2018189210A1

  公开（公告）日：2018-10-18

  The present invention relates to the fields of medicine and cancer treatment. The invention more specifically relates to new compounds which are typically for use as a medicament. In particular, the invention relates to the use of these new compounds for increasing the presentation, typically the production and presentation, of Pioneer Translation Products (PTPs)-derived antigens by cancer cells in a subject, and inducing or stimulating an immune response in the subject. The present disclosure also relates to uses of such compounds, in particular to prepare a pharmaceutical composition and/or to allow or improve the efficiency of a cancer therapy in a subject in need thereof. The invention also discloses methods for preventing or treating cancer, cancer metastasis and/or cancer recurrence in a subject. The present invention in addition provides kits suitable for preparing a composition according to the present invention and/or for implementing the herein described methods.

  本发明涉及医学和癌症治疗领域。该发明更具体地涉及通常用作药物的新化合物。特别是，该发明涉及利用这些新化合物来增加在受试者的癌细胞中由先驱翻译产物（PTPs）衍生的抗原的表达，通常是生产和展示，并在受试者中诱导或刺激免疫反应。本公开还涉及这些化合物的用途，特别是制备药物组合物和/或允许或改善受试者中癌症治疗的效率。该发明还揭示了用于预防或治疗受试者的癌症、癌症转移和/或癌症复发的方法。此外，本发明还提供了适用于根据本发明制备组合物和/或实施本文所述方法的试剂盒。
• Biflavanoids, norditerpenes and a nortriterpene from Podocarp us urbanii
  作者：Binayak Dasgupta、Basil A. Burke、Kenneth L. Stuartt

  DOI：10.1016/0031-9422(81)85236-3

  日期：1981.1

  Abstract The structures of a biflavanoid, two new norditerpenes, urbalactone and 2,3-dihydropodolide, an ecdysterol, as well as a known biflavanoid, nagilactone C and podolide from Podocarpus urbanii were elucidated.

  摘要 阐明了双黄酮、两种新的降二萜、urbalactone 和 2,3-dihydropodolide、蜕皮甾醇，以及已知的双黄酮、nagilactone C 和 Podocarpus Urbanii 的结构。
• Compounds, composition and uses thereof for treating cancer
  申请人：INSTITUT GUSTAVE ROUSSY

  公开号：US11110105B2

  公开（公告）日：2021-09-07

  The present invention relates to the fields of medicine and cancer treatment. The invention more specifically relates to new compounds which are typically for use as a medicament. In particular, the invention relates to the use of these new compounds for increasing the presentation, typically the production and presentation, of Pioneer Translation Products (PTPs)-derived antigens by cancer cells in a subject, and inducing or stimulating an immune response in the subject. The present disclosure also relates to uses of such compounds, in particular to prepare a pharmaceutical composition and/or to allow or improve the efficiency of a cancer therapy in a subject in need thereof. The invention also discloses methods for preventing or treating cancer, cancer metastasis and/or cancer recurrence in a subject. The present invention in addition provides kits suitable for preparing a composition according to the present invention and/or for implementing the herein described methods.

  本发明涉及医药和癌症治疗领域。更具体地说，本发明涉及通常用作药物的新化合物。特别是，本发明涉及这些新化合物的用途，用于增加受试者体内癌细胞对先锋转化产物（PTPs）衍生抗原的呈现，通常是产生和呈现，并诱导或刺激受试者的免疫反应。本发明还涉及此类化合物的用途，特别是制备药物组合物和/或允许或提高有需要的受试者的癌症治疗效率。本发明还公开了预防或治疗受试者癌症、癌症转移和/或癌症复发的方法。此外，本发明还提供了适用于制备根据本发明的组合物和/或实施本文所述方法的试剂盒。
• Kariyone; Kawano, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1956, vol. 76, p. 453,454
  作者：Kariyone、Kawano

  DOI：——

  日期：——
• Kariyone; Sawada, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1958, vol. 78, p. 1016,1018
  作者：Kariyone、Sawada

  DOI：——

  日期：——