Amentoflavon | 78511-92-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: Amentoflavon
• 英文别名: hexa-O-methylamentoflavone；Hexa-O-methylamentoflavon；amentoflavone hexamethyl ether；Ginkgetin-tetramethylaether；Amentoflavon-hexamethylether；Dioonflavone；8-[5-(5,7-dimethoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
• CAS: 78511-92-9
• 化学式: C₃₆H₃₀O₁₀
• 分子量: 622.628
• InChiKey: MZDGQNFFUITEAB-UHFFFAOYSA-N

物化性质

• 沸点：
  810.1±65.0 °C(predicted)
• 密度：
  1.301±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  46
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  Amentoflavon 在 氢氧化钾 作用下， 生成 3'-acetyl-6,2',4',6'-tetramethoxy-biphenyl-3-carboxylic acid
  参考文献：
  名称：

  Kawano, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1956, vol. 76, p. 457,458

  摘要：

  DOI：
• 作为产物：
  描述：

  3'-Jod-4',5,7-trimethoxy-flavon 在 四(三苯基膦)钯 硫酸 、 三氟化硼乙醚 、 碘 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 、 二甲基亚砜 为溶剂， 反应 25.0h， 生成 Amentoflavon
  参考文献：
  名称：

  A new strategy for the synthesis of biflavonoids via arylboronic acids.

  摘要：

  Amentoflavone derivatives were prepared by catalytic coupling of 8-flavoneboronic acids with iodoflavones. 3-Arylflavones, as biflavonoid synthon, are accessible by the method.

  DOI：

  10.1016/s0040-4039(00)79688-2

文献信息

• [EN] COMPOUNDS, COMPOSITION AND USES THEREOF FOR TREATING CANCER<br/>[FR] COMPOSÉS, COMPOSITION ET LEURS UTILISATIONS DANS LE TRAITEMENT DU CANCER
  申请人：ROUSSY INST GUSTAVE

  公开号：WO2018189210A1

  公开（公告）日：2018-10-18

  The present invention relates to the fields of medicine and cancer treatment. The invention more specifically relates to new compounds which are typically for use as a medicament. In particular, the invention relates to the use of these new compounds for increasing the presentation, typically the production and presentation, of Pioneer Translation Products (PTPs)-derived antigens by cancer cells in a subject, and inducing or stimulating an immune response in the subject. The present disclosure also relates to uses of such compounds, in particular to prepare a pharmaceutical composition and/or to allow or improve the efficiency of a cancer therapy in a subject in need thereof. The invention also discloses methods for preventing or treating cancer, cancer metastasis and/or cancer recurrence in a subject. The present invention in addition provides kits suitable for preparing a composition according to the present invention and/or for implementing the herein described methods.

  本发明涉及医学和癌症治疗领域。该发明更具体地涉及通常用作药物的新化合物。特别是，该发明涉及利用这些新化合物来增加在受试者的癌细胞中由先驱翻译产物（PTPs）衍生的抗原的表达，通常是生产和展示，并在受试者中诱导或刺激免疫反应。本公开还涉及这些化合物的用途，特别是制备药物组合物和/或允许或改善受试者中癌症治疗的效率。该发明还揭示了用于预防或治疗受试者的癌症、癌症转移和/或癌症复发的方法。此外，本发明还提供了适用于根据本发明制备组合物和/或实施本文所述方法的试剂盒。
• Biological Investigation of a Water-Soluble Isoginkgetin-Phosphate Analogue, Targeting the Spliceosome with<i>In Vivo</i>Antitumor Activity
  作者：Boris Letribot、Megane Nascimento、Giulia Cerrato、Romain Darrigrand、Valerie Salgues、Dolor Renko、Alain Pruvost、Mouad Alami、Samir Messaoudi、Sebastien Apcher

  DOI：10.1021/acs.jmedchem.1c01654

  日期：2022.3.24

  The first total synthesis of the natural product Isoginkgetin as well as four water-soluble Isoginkgetin-phosphate analogues is reported herein. Moreover, the full study of the IP2 phosphate analogue with respect to pharmacological properties (metabolic and plasmatic stabilities, pharmacokinetic, off-target, etc.) as well as in vitro and in vivo biological activities are disclosed herein.

  本文报道了天然产物异银杏素以及四种水溶性异银杏素-磷酸类似物的首次全合成。此外，本文公开了IP2磷酸类似物在药理学特性（代谢和血浆稳定性、药代动力学、脱靶等）以及体外和体内生物活性方面的全面研究。
• Nakazawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1941, vol. 61, p. 174,178, 183, 228; dtsch. Ref. Nr. 6, S. 72, 90
  作者：Nakazawa

  DOI：——

  日期：——
• Nakazawa, Chemical and pharmaceutical bulletin, 1959, vol. 7, p. 748,749
  作者：Nakazawa

  DOI：——

  日期：——
• Tetrahydroamentoflavone from nuts of Semecarpus prainii
  作者：Iqbal Ahmad、Khwaja Ishratullah、M. Ilyas、W. Rahman、Otto Seligmann、Hildebert Wagner

  DOI：10.1016/0031-9422(81)83061-0

  日期：1981.1