2,2-Dimethyl-N-[6-(quinolin-8-yloxymethyl)-pyridin-2-yl]-propionamide | 909297-16-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,2-Dimethyl-N-[6-(quinolin-8-yloxymethyl)-pyridin-2-yl]-propionamide
• 英文别名: 2,2-dimethyl-N-[(6-(quinolin-8-yl)oxymethyl)pyridin-2-yl]propionamide
• CAS: 909297-16-1
• 化学式: C₂₀H₂₁N₃O₂
• 分子量: 335.406
• InChiKey: HFWMXYIBPRYWDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.19
• 重原子数：
  25.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  64.11
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-N-[6-(quinolin-8-yloxymethyl)-pyridin-2-yl]-propionamide 在 水 、 三乙胺 、 potassium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 47.0h， 生成
  参考文献：
  名称：

  使用设计的合成受体识别肌酐

  摘要：

  合成了一系列中性非酶受体，以非变性方式识别肌酐。受体含有不同的杂环部分，以促进宿主和客人之间的相互作用。在这些当中，1，4和5是荧光受体肌酸酐。从该研究中发现，含有萘啶部分的受体1和4对客体肌酐的结合亲和力高于含有其他杂环部分的受体。使用宿主的离散傅里叶变换（DFT）及其在气相和乙腈介质中与肌酐的络合进行了计算结合能的理论研究。

  DOI：

  10.1002/poc.4066
• 作为产物：
  描述：

  2-特戊酰氨基-6-甲基吡啶 在 N-溴代丁二酰亚胺(NBS) 、 四丁基溴化铵 、 potassium carbonate 、 potassium iodide 作用下， 以 四氯化碳 、 N,N-二甲基甲酰胺 为溶剂， 生成 2,2-Dimethyl-N-[6-(quinolin-8-yloxymethyl)-pyridin-2-yl]-propionamide
  参考文献：
  名称：

  Fluorescence sensing of tartaric acid: a case of excimer emission caused by hydrogen bond-mediated complexation

  摘要：

  A novel quinoline based receptor that shows monomer emission quenching followed by intramolecular excimer emission upon hydrogen bond mediated complexation of tartaric acid has been designed and synthesized. The excimer emission has been used to confirm the selective recognition of tartaric acid over its nonhydroxy analogue, succinic acid. Binding ability was studied by H-1 NMR, UV-vis and fluorescence spectroscopic methods. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.03.044

文献信息

• A quinoline-based tripodal fluororeceptor for citric acid
  作者：Kumaresh Ghosh、Suman Adhikari

  DOI：10.1016/j.tetlet.2007.11.139

  日期：2008.1

  The quinoline-based tripodal fluororeceptor 1 has been designed and synthesized for the detection of citric acid in less polar solvents. Receptor I shows monomer emission quenching followed by excimer emission upon hydrogen bond-mediated complexation of citric acid. In comparison, receptor 2, in presence of the same acid, gives rise to a decrease in the monomer emission of the naphthyl moiety without showing any peak for the excimer. Receptor 1 is found to bind citric acid more strongly than receptor 2 in CHCl3 (c) 2007 Elsevier Ltd. All rights reserved.
• Metal ion based chiral fluorescence sensor selective for dihydrogenphosphate
  作者：Shyamaprosad Goswami、Debabrata Sen、Nirmal Kumar Das

  DOI：10.1016/j.tetlet.2010.10.034

  日期：2010.12

  A Cu(II) based conformationally restricted chiral fluorescence sensor (receptor 2) has been designed and synthesized for selective sensing of anions. The anion recognition property of the Cu2+-complex has been studied in acetonitrile by fluorescence methods which show remarkable sensitivity toward dihydrogen phosphate via fluorescence modulation of the Cu2+-complex over the other anions examined. (C) 2010 Elsevier Ltd. All rights reserved.