acridine-9-carboxylic acid hydrochloride | 158788-57-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: acridine-9-carboxylic acid hydrochloride
• 英文别名: Acridine-9-carboxylic acid hydrochloride；acridine-9-carboxylic acid;hydrochloride
• CAS: 158788-57-9
• 化学式: C₁₄H₉NO₂*ClH
• 分子量: 259.692
• InChiKey: AZWYMVWCEKEQBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.51
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  acridine-9-carboxylic acid hydrochloride 、 氯化亚砜 在 氮气 、 乙醚 作用下， 反应 2.0h， 以to give acridine-9-carbonyl chloride hydrochloride的产率得到9-Acridinecarbonyl chloride hydrochloride
  参考文献：
  名称：

  Long emission wavelength chemiluminescent compounds and their use in

  摘要：

  本文描述了一种至少包含两种不同化学发光化合物的测定方法，用于检测和/或定量测试样品中的至少两种物质。还公开了用于这种方法的化学发光试剂或共轭物的合成，以及包含这种试剂的试剂盒。这些测定方法在临床诊断领域具有特殊应用。

  公开号：

  US05879894A1

文献信息

• Novel compounds for chemiluminescense procedures
  申请人：——

  公开号：US20040214999A1

  公开（公告）日：2004-10-28

  The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converted into the leaving group. The invention also relates to compounds additionally comprising a coupling group to the use of such compounds for labeling of biomolecules and more generally to the use of such compounds in chemiluminescence detection procedures.

  本发明涉及一种化学化合物，包括一个发光基团前体和一个离去基团前体的前体，它们通过酰胺或酯键相互结合，并且其特征在于，当离去基团前体氧化时，将转化为离去基团。本发明还涉及化合物，还包括一个偶联基团，用于标记生物分子，更一般地，用于化学发光检测程序中使用这种化合物。
• Chemiluminescent compounds
  申请人：Weeks Ian

  公开号：US20070166759A1

  公开（公告）日：2007-07-19

  The invention relates to chemiluminescent compounds of general formula: (I) wherein: either: R 1 is a reactive group capable of reacting with an amine or thiol moiety; L 1 is a hydrocarbon linker moiety comprising 2-12 carbon atoms, optionally substituted with hydroxy, halo, nitro or C 1 -C 4 alkoxy; and R 2 is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, aryl, fused aryl, C 1 -C 4 alkoxy, C 1 -C 4 acyl, halide, hydroxy or nitro; or, alternatively: the combination R 1 -L 1 - comprises a C 1 -C 4 alkyl group optionally substituted with hydroxy, halo, nitro or C 1 -C 4 alkoxy; and R 2 comprises a group R 4 -L 1 -, where R 4 is a reactive group capable of reacting with an amine or thiol moiety; and L 1 is as defined above; L 2 is —C(═O)O—, —C(═O)—S— or —C(═O)N(SO 2 R 5 )—, wherein, in each case, the —C(═O) is linked to the ring carbon atom, and R 5 is C 1 -C 8 alkyl, aryl, C 1 -C 8 alkoxy or C 1 -C 8 acyl; R 3 a substituted C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 1 -C 8 alkynyl or aryl group wherein at least one of the said substituents is electron-withdrawing such that the pKa of the conjugate acid of the leaving group formed from R 3 and the —O, —S or —N(SO 2 R 5 ) of the L 2 group is ≦ about 9.5; and X − is an anion formed as the result of the synthesis and processing of the molecule; wherein the compound may contain one or more additional R 2 moieties on either or both outer rings, provided that only one of said R 2 moieties may comprise an R 4 -L 1 -group.

  该发明涉及通式为（I）的化学发光化合物，其中：要么：R1是能够与胺或硫醇基团反应的反应性基团；L1是包含2-12个碳原子的烃链连接基团，可选地被羟基，卤素，硝基或C1-C4烷氧基取代；R2是氢，C1-C4烷基，C1-C4卤代烷基，芳基，融合的芳基，C1-C4烷氧基，C1-C4酰基，卤素，羟基或硝基；或者，R1-L1-的组合包括一个可选地被羟基，卤素，硝基或C1-C4烷氧基取代的C1-C4烷基；R2包括一个R4-L1-基团，其中R4是能够与胺或硫醇基团反应的反应性基团；L1如上所定义；L2是—C(═O)O—，—C(═O)—S—或—C(═O)N(SO2R5)—，其中，在每种情况下，—C(═O)与环上的碳原子连接，并且R5是C1-C8烷基，芳基，C1-C8烷氧基或C1-C8酰基；R3是取代的C1-C8烷基，C2-C8烯基，C1-C8炔基或芳基基团，其中至少一个取代基是电子提取基团，使得由R3和L2中的—O，—S或—N(SO2R5)形成的离去基的共轭酸的pKa≤约9.5；X-是分子合成和处理的结果形成的阴离子；其中化合物可以在一个或两个外环上包含一个或多个额外的R2基团，只有一个该R2基团可以包含一个R4-L1-基团。
• Chemiluminescent Compounds
  申请人：WEEKS Ian

  公开号：US20110082279A1

  公开（公告）日：2011-04-07

  The invention relates to chemiluminescent compounds of general formula (I) wherein: either: R 1 is a reactive group capable of reacting with an amine or thiol moiety; L 1 is a hydrocarbon linker moiety comprising 2-12 carbon atoms, optionally substituted with hydroxy, halo, nitro or C 1 -C 4 alkoxy; and R 2 is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, aryl, fused aryl, C 1 -C 4 alkoxy, C 1 -C 4 acyl, halide, hydroxy or nitro; or, alternatively: the combination R 1 -L 1 - comprises a C 1 -C 4 alkyl group optionally substituted with hydroxy, halo, nitro or C 1 -C 4 alkoxy; and R 2 comprises a group R 4 -L 1 -, where R 4 is a reactive group capable of reacting with an amine or thiol moiety; and L 1 is as defined above; L 2 is —C(═O)O—, —C(═O)—S— or —C(═O)N(SO 2 R 5 )—, wherein, in each case, the —C(═O) is linked to the ring carbon atom, and R 5 is C 1 -C 8 alkyl, aryl, C 1 -C 8 alkoxy or C 1 -C 8 acyl; R 3 is a substituted C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl or aryl group wherein at least one of the said substituents is electron-withdrawing such that the pKa of the conjugate acid of the leaving group formed from R 3 and the —O, —S or —N(SO 2 R 5 ) of the L 2 group is ≦about 9.5; and X − is an anion formed as the result of the synthesis and processing of the molecule; wherein the compound may contain one or more additional R 2 moieties on either or both outer rings, provided that only one of said R 2 moieties may comprise an R 4 -L 1 -group.

  本发明涉及通式（I）的化学发光化合物，其中： 要么： R1是能够与胺或硫醇基团反应的反应性基团； L1是一个含有2-12个碳原子的烃链连接基团，可选地被羟基，卤素，硝基或C1-C4烷氧基取代； R2是氢，C1-C4烷基，C1-C4卤代烷基，芳基，融合芳基，C1-C4烷氧基，C1-C4酰基，卤素，羟基或硝基； 或者，另一种情况是： 组合R1-L1-包括一个C1-C4烷基，可选地被羟基，卤素，硝基或C1-C4烷氧基取代； R2包括一个R4-L1-基团，其中R4是能够与胺或硫醇基团反应的反应性基团；L1如上定义； L2是-C（═O）O-，-C（═O）-S-或-C（═O）N（SO2R5）-，在每种情况下，-C（═O）连接到环碳原子，并且R5是C1-C8烷基，芳基，C1-C8烷氧基或C1-C8酰基； R3是取代的C1-C8烷基，C2-C8烯基，C2-C8炔基或芳基，其中至少一个取代基是电子吸引基团，使得由R3和L2基团的-O，-S或-N（SO2R5）形成的离去基的共轭酸的pKa ≦约9.5； X-是分子合成和处理的结果形成的阴离子；其中化合物可以在一个或两个外环上包含一个或多个额外的R2基团，只有其中一个R2基团可以包含一个R4-L1-基团。
• Base modified nucleosides
  申请人：ABBOTT LABORATORIES

  公开号：EP0407816A2

  公开（公告）日：1991-01-16

  The present invention relates to the preparation and isolation of 5-position modified uracil nucleosides and nucleotides and to their use in the synthesis of labeled oligonucleotides useful as nucleic acid probes. More specifically, the present invention provides for improved methods for the preparation of novel 5-aza uracil nucleoside derivatives wherein a 5-halo-uracil nucleoside is reacted with a bifunctional amine, such as diamines, a sulfhydrylamino compound, or an hydroxyamino compounds, to yield the corresponding 5-(aza-aminoalkyl)uracil nucleoside, 5-(aza-sulfhydrylalkyl)uracil nucleoside or 5-(aza-hydroxyalkyl)uracil nucleoside, respectively, and for improved methods for the isolation of the products formed. These uracil nucleoside derivatives can be used as substrates in a method for preparing novel labeled oligonucleotides of DNA. Reporter groups can be attached either before or after the preparation of the oligonuclectides. These reporter group labeled oligonucleotides are especially useful when incorporated into nucleic acid probes which readily can be used in hybridization studies to form hybrids with either DNA or RNA.

  本发明涉及 5 位修饰尿嘧啶核苷和核苷酸的制备和分离，以及它们在合成用作核酸探针的标记寡核苷酸中的用途。更具体地说，本发明提供了制备新型 5-aza 尿嘧啶核苷衍生物的改进方法，其中 5-卤代尿嘧啶核苷与双官能胺（如二胺、巯基氨基化合物或羟基氨基化合物）反应、或羟基氨基化合物反应，分别得到相应的 5-(偶氮氨基烷基)尿嘧啶核苷、5-(偶氮-巯基烷基)尿嘧啶核苷或 5-(偶氮-羟基烷基)尿嘧啶核苷，并改进分离所形成产物的方法。这些尿嘧啶核苷衍生物可在制备新型标记 DNA 寡核苷酸的方法中用作底物。报告基团可以在制备寡核苷酸之前或之后连接。这些标记了报告基团的寡核苷酸在加入核酸探针时特别有用，因为核酸探针可随时用于杂交研究，与 DNA 或 RNA 形成杂交。
• Novel N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
  申请人：LUMIGEN, INC.

  公开号：EP0625510A2

  公开（公告）日：1994-11-23

  N-alkylacridan carboxylic acid derivative compounds (I) are used to generate chemiluminescence by the action of a peroxidase enzyme and an oxidant. The compounds I are useful in assays of all types.

  N- 烷基吖啶羧酸衍生物化合物（I）可在过氧化物酶和氧化剂的作用下产生化学发光。化合物 I 适用于各种类型的检测。