N-β-叔丁氧羰基-L-Alpha,β-二氨基丙酸甲酯盐酸盐

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-β-叔丁氧羰基-L-Alpha,β-二氨基丙酸甲酯盐酸盐
• 中文别名: 甲氧基氨酸盐酸盐；N-β-叔丁氧羰基-L-α,β-二氨基丙酸甲酯盐酸盐；N'-叔丁氧羰基-D-2,3-二氨基丙酸甲酯盐酸盐；BOC保护的甲氧基氨酸盐酸盐
• 英文名称: methyl (S)-2-amino-3-tert-butoxycarbonylaminopropanoate hydrochloride
• 英文别名: (S)-methyl 2-amino-3-((tert-butoxycarbonyl)amino)propanoate hydrochloride；H-Dap(Boc)-OMe·HCl；H-Dap(Boc)-OMe hydrochloride；[(2S)-1-methoxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-1-oxopropan-2-yl]azanium;chloride
• 化学式: C₉H₁₈N₂O₄*ClH
• 分子量: 254.714
• InChiKey: GDJLJNFNXINTHS-RGMNGODLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.43
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  90.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-β-叔丁氧羰基-L-Alpha,β-二氨基丙酸甲酯盐酸盐 在 三乙酰氧基硼氢化钠 、 N,N-二异丙基乙胺 作用下， 以 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 (S)-2-[Benzyl-(2-oxo-butyl)-amino]-3-tert-butoxycarbonylamino-propionic acid methyl ester
  参考文献：
  名称：

  2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists

  摘要：

  We report the discovery and optimization of substituted 2-piperazinecarboxamides as potent and selective agonists of the melanocortin subtype-4 receptor. The 5- and 6-alkylated piperazine compounds exhibit low bioactivation potential as measured by covalent binding in microsome preparations. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.068
• 作为产物：
  描述：

  (S)-2-N-Cbz-3-N-Boc-丙酸甲酯 在 palladium on activated charcoal 盐酸 、 氢气 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以80%的产率得到N-β-叔丁氧羰基-L-Alpha,β-二氨基丙酸甲酯盐酸盐
  参考文献：
  名称：

  Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-Diaminopropionic acid derivatives as surrogates of aspartic acid

  摘要：

  In an effort to discover novel nonpeptide glycoprotein IIb/IIIa (GPIIb/lIIa, alpha(IIb)/beta 3) inhibitors, we investigated RGD mimetics featuring a 3-substituted benzoic acid as the core, benzamidine as the basic moiety, and a series of beta- and alpha-substituted beta-alanine derivatives as aspartic acid surrogates. It was found that the use of beta-methyl beta-alanine slightly improved the anti-aggregant potency in human platelet-rich plasma over the unsubstituted beta-alanine compound, while alpha-substitution with a trifluoromethyl group resulted in considerable loss in activity. Significant enhancement (up to 100-fold) in potency was obtained when the beta-alanine was replaced with N-2-substituted L-2,3-diaminopropionic acid derivatives. Among the three types of cc-substituents (carbamate, amide, and sulfonamide) investigated, no apparent preference was observed with respect to in vitro potency. However, alkyl groups were more favorable than arylalkyl groups (Cbz) in the carbamate analogues. We also investigated piperidine, piperazine, and N-formamidinopiperidine as replacements for the benzamidine moiety. The former two replacements led to a drop in potency while the latter replacement resulted in maintenance of activity as compared with the corresponding benzamidine analogue. (C) 1997 The DuPont Merck Pharmaceutical Company. Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)00013-8

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS<br/>[FR] COMPOSÉS ET MÉTHODES POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2018006063A1

  公开（公告）日：2018-01-04

  Compositions and methods for the treatment of bacterial infections include compounds containing dimers of cyclic heptapeptides conjugated to one or more monosaccharide or oligosaccharide moieties. In particular, compounds can be used in the treatment of bacterial infections caused by Gram-negative bacteria.

  用于治疗细菌感染的组合物和方法包括含有环七肽二聚体与一个或多个单糖或寡糖基团结合的化合物。特别是，这些化合物可用于治疗由革兰氏阴性细菌引起的细菌感染。
• High-Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging α_v β₃ Integrin
  作者：Monica Piras、Andrea Testa、Ian N. Fleming、Sergio Dall'Angelo、Alexandra Andriu、Sergio Menta、Mattia Mori、Gavin D. Brown、Duncan Forster、Kaye J. Williams、Matteo Zanda

  DOI：10.1002/cmdc.201700328

  日期：2017.7.20

  αIIb β3 receptors was investigated by molecular modeling simulations. Lead compound 12 was successfully radiofluorinated and used for in vivo positron emission tomography/computed tomography (PET/CT) studies in U87 tumor models, which showed only modest tumor uptake and retention, owing to rapid excretion. These results demonstrate that the novel click RGD mimics are excellent radiolabeled probes for in vitro

  通过精氨酸-叠氮化物模拟物和天冬氨酸-炔模拟物之间的点击化学设计并合成了非肽Arg-Gly-Asp（RGD）-模拟配体。这些分子中的一些结合了出色的体外特性（高αvβ3亲和力，选择性，类药物logD，高代谢稳定性）和多种放射性标记选项（例如tri和氟-18，以及与放射性碘的相容性），需要使用螯合剂或假肢。通过分子模拟模拟研究了所得三唑RGD模拟物与αvβ3或αIIbβ3受体的结合模式。铅化合物12已成功地被氟化，并用于U87肿瘤模型的体内正电子发射断层扫描/计算机断层扫描（PET / CT）研究，由于快速排泄，该研究仅显示了适度的肿瘤吸收和保留。
• [EN] MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS<br/>[FR] ANTIBIOTIQUES MACROCYCLIQUES À LARGE SPECTRE
  申请人：RQX PHARMACEUTICALS INC

  公开号：WO2018149419A1

  公开（公告）日：2018-08-23

  Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

  本文提供了抗菌化合物，其中在某些实施例中，这些化合物具有广谱生物活性。在各种实施例中，这些化合物通过抑制细菌类型1信号肽酶（SpsB）发挥作用，这是细菌中的一种必需蛋白质。还提供了使用所述化合物的药物组合物和治疗方法。
• [EN] MODULATORS OF CELLULAR ADHESION<br/>[FR] MODULATEURS DE L'ADHESION CELLULAIRE
  申请人：SUNESIS PHARMACEUTICALS INC

  公开号：WO2005044817A1

  公开（公告）日：2005-05-19

  The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).

  本发明提供具有以下式（I）的化合物及其药学上可接受的衍生物，其中R1-R4、n、p、A、B、D、E、L和AR1如本文中一般描述的那样，并且另外提供这些药物组合物以及用于治疗由CD11/CD18细胞粘附分子家族介导的疾病（例如LFA-1）的使用方法。
• NOVEL NITROGEN-CONTAINING COMPOUND OR SALT THEREOF, OR METAL COMPLEX THEREOF
  申请人：FUJIFILM Corporation

  公开号：US20160199520A1

  公开（公告）日：2016-07-14

  The present invention provides a compound represented by the formula (1) or a salt thereof, or a complex of the compound or the salt with a metal, in the formula (1), A 1 represents a chelate group; R 1 represents a hydrogen atom or the like; R 2 represents a hydrogen atom or the like; and Z 1 , Z 2 , Z 3 , Z 4 , and Z 5 are the same or different and each represent a nitrogen atom or CR 3 or the like wherein R 3 represents a hydrogen atom or an optionally substituted C 1-6 alkyl group or the like; L 1 represents a group represented by the formula (3) wherein R 13 , R 14 , R 15 , and R 16 are the same or different and each represent a hydrogen atom or the like; L 2 represents an optionally substituted C 1-6 alkylene group; and L 3 represents an optionally substituted C 1-6 alkylene group.

  本发明提供了由式（1）表示的化合物或其盐，或者该化合物或盐与金属形成的络合物，其中在式（1）中，A1代表螯合基团；R1代表氢原子或类似物；R2代表氢原子或类似物；Z1、Z2、Z3、Z4和Z5相同或不同，每个代表氮原子或CR3或类似物，其中R3代表氢原子或可选择取代的C1-6烷基基团或类似物；L1代表由式（3）表示的基团，其中R13、R14、R15和R16相同或不同，每个代表氢原子或类似物；L2代表可选择取代的C1-6亚烷基基团；L3代表可选择取代的C1-6亚烷基基团。