苯并[a]芘 - CAS号 50-32-8

物化性质

熔点：

177-180°C
沸点：

495°C
密度：

1.1549 (estimate)
闪点：

495°C
溶解度：

Soluble in benzene, toluene, and xylene; sparingly soluble in ethanol and methanol (Windholz et al., 1983)
暴露限值：

OSHA: TWA 0.2 mg/m3
物理描述：

Benzo[a]pyrene appears as a liquid. Presents a threat to the environment. Immediate steps should be taken to limits its spread to the environment. Easily penetrates the soil and contaminates groundwater or nearby waterways.
颜色/状态：

Pale yellow monoclinic needles from benzene and methanol
气味：

Faint aromatic odor
蒸汽密度：

8.7 (NTP, 1992) (Relative to Air)
蒸汽压力：

5.49X10-9 mm Hg at 25 °C /extrapolated value/
亨利常数：

4.57e-07 atm-m3/mole
稳定性/保质期：

<b><p></p></b>
分解：

Hazardous decomposition products formed under fire conditions - Carbon oxides.[Sigma-Aldrich; Safety Data Sheet for Benzo
汽化热：

Enthalpy of vaporization: 91.0 kJ/mol (323-473 K)[NIST; NIST Chemistry WebBook. Benzo
相对蒸发率：

Evaporation at 20 °C is negligible
碰撞截面：

152.05 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]
保留指数：

2798;2763;2764;2778;2809;2813;2817;2828;2822;2828;2830;2786.2;2808.6;2829.6;453.4;453.4;453.4;451.8;451.2;453.4;453.9;454.7;455.4;453;453.6

计算性质

辛醇/水分配系数(LogP)：

6
重原子数：

20
可旋转键数：

0
环数：

5.0
sp3杂化的碳原子比例：

0.0
拓扑面积：

0
氢给体数：

0
氢受体数：

0

ADMET

代谢

在脾白细胞制备中，巨噬细胞是能够将苯并[a]芘（BaP）代谢为7,8-二羟基-9,10-环氧-苯并[a]芘（BPDE）的主要细胞类型，BPDE被认为是BaP最终致癌和免疫毒性的反应代谢物。

/It was/ demonstrated that macrophages were the primary cell type in a splenic leukocyte preparation capable of metabolizing /benzo[a]pyrene/ BaP to 7,8-dihydroxy-9,10-epoxy-benzo[a]pyrene (BPDE), the reactive metabolite proposed to be the ultimate carcinogenic and immunotoxic form of BaP.

来源:Hazardous Substances Data Bank (HSDB)

代谢

来自13个不同个体的human liver microsomal fractions（人类肝脏微粒体组分）的特征描述如下：在分子量范围49,000-60,000的微粒体蛋白组成中发现了明显的个体间差异。微粒体蛋白图谱的大部分变异是cytochrome P450（细胞色素P450）的异构酶组成的个体间差异。在人类肝脏微粒体样本中，benzo[a]pyrene（苯并[a]芘）代谢显示了大的变异。结果表明，人类肝脏微粒体中存在7-8种不同形式的cytochrome P450，药物代谢中的个体间差异至少部分可以由这些异构酶分布的变异来解释。

Human liver microsomal fractions from 13 different individuals were characterized ... . Pronounced interindividual differences in the composition of microsomal proteins in the mol wt range of 49,000-60,000 were found. Most of the variations among profiles of microsomal proteins are interindividual differences in the composition of isoenzymes of cytochrome P450. Large variations among the human liver microsomal samples were seen in benzo[a]pyrene metabolism. The results indicate the presence of 7-8 different forms of cytochrome P450 in human liver microsomes and interindividual variations seen in drug metabolism may at least in part be explained by variations in the distribution of these isoenzymes.

来源:Hazardous Substances Data Bank (HSDB)

代谢

来自溃疡性结肠炎患者和正常人的结肠活检标本被研究其对苯并[a]芘的代谢能力。大约73%的来自7名溃疡性结肠炎患者的30个结肠活检标本能够将苯并[a]芘代谢为氧化产物，平均产量为11.6 nmol/mg活检蛋白。相比之下，来自5名正常人的23个活检标本中有39%显示出平均代谢活性，为2.79 nmol。溃疡性结肠炎患者结肠组织的苯并[a]芘氧化活性平均而言是正常人的四倍。这项研究表明，溃疡性结肠炎患者的结肠粘膜对这类化学物质进行氧化的能力可能比正常人更强，可能产生具有更高突变潜力的亲电物质。

Colonic biopsy specimens from patients with ulcerative colitis and normal subjects were studied for the ability to metabolize benzo[a]pyrene. Approx 73% of 30 colonic biopsy specimens from 7 ulcerative colitis patients could metabolize benzo[a]pyrene to oxidized products, with an average production of 11.6 nmol/mg biopsy protein. In contrast, 39% of 23 biopsy specimens from 5 normal persons showed an average metabolic activity, 2.79 nmol. Benzo[a]pyrene oxidation activity in colonic tissue from colitis patients was, on the average, fourfold greater than that in normal subjects. This study suggest that the colonic mucosa of patients with ulcerative colitis has a greater ability than that of normal subjects to oxidize such chemicals possibly to electrophiles with higher mutagenic potential.

来源:Hazardous Substances Data Bank (HSDB)

代谢

苯并[a]芘被代谢成大约20种初级和次级氧化代谢物以及多种结合物。其中几种代谢物可以诱导突变、转化细胞和/或结合到细胞大分子上；然而，目前只有7,8-二醇-9,10-环氧化物被认为是一种终极致癌代谢物。

Benzo[a]pyrene is metabolized to approximately 20 primary and secondary oxidized metabolites and to a variety of conjugates. Several metabolites can induce mutations, transform cells and/or bind to cellular macromolecules; however only a 7,8-diol-9,10-epoxide is presently considered to be an ultimate carcinogenic metabolite.

来源:Hazardous Substances Data Bank (HSDB)

代谢

苯并[a]芘已知的人类代谢物包括苯并[a]芘-4,5-环氧化物、9-羟基苯并[a]芘、1-羟基苯并[a]芘、苯并[a]芘-7,8-环氧化物和3-羟基苯并[a]芘。

Benzo[a]pyrene has known human metabolites that include Benzo[a]pyrene-4,5-epoxide, 9-Hydroxybenzo[a]pyrene, 1-Hydroxybenzo[a]pyrene, Benzo[a]pyrene-7,8-epoxide, and 3-Hydroxybenzo[a]pyrene.

来源:NORMAN Suspect List Exchange

毒理性

毒性总结

识别和使用：苯并[a]芘（BaP）是一种五环多环芳烃（PAH）。苯并[a]芘（连同其他PAHs）作为烟雾的一部分释放到大气中，来源于森林火灾、工业过程、车辆尾气、香烟以及燃料（如木材、煤炭和石油产品）的燃烧。人类暴露和毒性：流行病学研究涉及暴露于PAH混合物，报告了内部生物标志物暴露于苯并[a]芘（苯并[a]芘二醇环氧化物-DNA加合物）与不良出生结果（包括出生体重降低、出生后体重和头围减小）、神经行为效应和生育能力下降之间的关联。此外，有强有力的证据表明，在与含有苯并[a]芘的PAH混合物接触的职业中存在致癌性，例如铝生产、扫烟囱、煤气化、煤焦油蒸馏、焦炭生产、铁和钢铸造以及使用煤焦油沥青铺路和屋顶。越来越多的职业研究表明，累积BaP暴露与肺癌之间存在正向暴露-反应关系。BaP在人类MCL-5细胞中具有突变性。BaP在焦化工人的血液血浆中的积累在淋巴细胞微核的形成中发挥了主要作用。描述了在172名19-95岁正常个体的淋巴细胞培养中，由激活的苯并[a]芘二醇环氧化物（BPDE）诱发的染色体畸变的特点。BPDE诱导的染色体畸变主要是单染色单体断裂，很少有等染色单体断裂或交换图形。苯并[a]芘的遗传毒性作用机制涉及代谢为高度反应性的物种，形成与DNA的共价加合物。这些反苯并[a]芘-7,8-二醇-9,10-氧化物-DNA加合物在人类肺癌肿瘤中诱导K-RAS原癌基因和TP53肿瘤抑制基因的突变，并在小鼠肺癌肿瘤的相应基因中诱导突变。动物研究：动物研究表明，暴露于苯并[a]芘与发育（包括发育神经毒性）、生殖和免疫效应有关。在多种动物物种的研究表明，苯并[a]芘通过所有暴露途径在多个肿瘤部位（消化道、肝脏、肾脏、呼吸道、咽部和皮肤）具有致癌性。BaP主要代谢为二醇环氧化物，它们主要在DNA的N2-dG位置反应。已经证明BaP-N2-dG加合物能诱导多种突变，尤其是G-->T、G-->A、G-->C和-1框移。口服暴露于BaP会在小鼠中引起精原干细胞突变。生态毒性研究：34只鸭子单次气管内给药50-200毫克苯并[a]芘。存活率很低。一只鸭子发展为肺癌，两只出现支气管鳞状上皮化生。对在0.00、0.08、0.21、0.39、1.48、2.40或2.99 ng/mL水溶液苯并[a]芘中养殖的虹鳟鱼卵进行组织学和骨骼检查。在BaP处理的鱼卵中，神经外胚层和间充质衍生物以及肝脏中最常见的核固缩和核破裂。17%的测试鱼出现微眼症，并经常与开放的视神经裂隙相关。在0.21至1.48 ng/mL水溶液BaP中养殖的鱼卵在视网膜和大脑中，但不在肝脏中，观察到减低的有丝分裂率。测试鱼卵在头骨和脊椎柱中显著更高比例的骨骼畸形，脊椎弧形的异常经常与脊柱侧弯区域相对应。在紫色海胆（Strongylocentrotus purpuratus）中，致畸效应与胚胎细胞毒性和遗传毒性有关，表现为有丝分裂期间异常染色体排列的存在。在用1-50 ng/mL初始苯并[a]芘浓度处理的胚胎层中观察到发育异常。

IDENTIFICATION AND USE: Benzo[a]pyrene (BaP) is a five-ring polycyclic aromatic hydrocarbon (PAH). Benzo[a]pyrene (along with other PAHs) is released into the atmosphere as a component of smoke from forest fires, industrial processes, vehicle exhaust, cigarettes, and through the burning of fuel (such as wood, coal, and petroleum products). HUMAN EXPOSURE AND TOXICITY: Epidemiology studies involving exposure to PAH mixtures have reported associations between internal biomarkers of exposure to benzo[a]pyrene (benzo[a]pyrene diol epoxide-DNA adducts) and adverse birth outcomes (including reduced birth weight, postnatal body weight, and head circumference), neurobehavioral effects, and decreased fertility. In addition, there is strong evidence of carcinogenicity in occupations involving exposure to PAH mixtures containing benzo[a]pyrene, such as aluminum production, chimney sweeping, coal gasification, coal-tar distillation, coke production, iron and steel founding, and paving and roofing with coal tar pitch. An increasing number of occupational studies demonstrate a positive exposure-response relationship with cumulative BaP exposure and lung cancer. BaP was mutagenic in human MCL-5 cells. Accumulation of BaP in blood plasma of coking workers played a major role in the formation of lymphocyte micronucleus. The characteristics of chromosomal aberrations induced in vitro by activated benzo[a]pyrene diol epoxide (BPDE) in lymphocyte cultures of 172 normal individuals ages 19-95 years were described. The BPDE-induced chromosomal aberrations were predominantly single chromatid breaks, with few isochromatid breaks or exchange figures. The genotoxic mechanism of action of benzo[a]pyrene involves metabolism to highly reactive species that form covalent adducts to DNA. These anti-benzo[a]pyrene-7,8-diol- 9,10-oxide-DNA adducts induce mutations in the K-RAS oncogene and the TP53 tumorsuppressor gene in human lung tumors, and in corresponding genes in mouse-lung tumors. ANIMAL STUDIES: Animal studies demonstrate that exposure to benzo[a]pyrene is associated with developmental (including developmental neurotoxicity), reproductive, and immunological effects. Studies in multiple animal species demonstrate that benzo[a]pyrene is carcinogenic at multiple tumor sites (alimentary tract, liver, kidney, respiratory tract, pharynx, and skin) by all routes of exposure. BaP is primarily metabolized to diol epoxides, which react principally at N2-dG in DNA. BaP-N2-dG adducts have been shown to induce a variety of mutations, notably G-->T, G-->A, G-->C and -1 frameshifts. Oral exposure to BaP causes spermatogonial stem cell mutations in mice. ECOTOXICITY STUDIES: Thirty-four ducks were given single intratracheal dose of 50-200 mg benzo(a)pyrene. Survival rate was poor. One duck developed a lung carcinoma, and two had bronchial squamous metaplasia. Histological and skeletal examinations were performed on rainbow trout alevins reared in 0.00, 0.08, 0.21, 0.39, 1.48, 2.40, or 2.99 ng/mL aqueous benzo[a]pyrene (BaP). Nuclear pycnosis and karyorrhexis were most common in neuroectodermal and mesodermal derivatives and in liver of BaP-treated alevins. Microphthalmia was noted in 17% of the test fish and was frequently associated with a patent optic fissure. Depressed mitotic rates in the retina and brain, but not liver, were seen in alevins reared in 0.21 to 1.48 ng/mL aqueous BaP. Test alevins had a significantly higher incidence of skeletal malformations in the skull and vertebral column and abnormalities of vertebral arcualia often corresponded to areas of kyphoscoliotic flexures. In the purple sea urchin (Strongylocentrotus purpuratus) teratogenic effect were related to embryonic cytotoxicity and genotoxicity as evidenced by the presence of aberrant chromosome arrangements during mitosis. Developmental abnormalities were observed in gastrulae treated with initial benzo(a)pyrene concentrations of 1-50 ng/mL.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

毒性总结

多环芳烃（PAHs）能够与血液中的蛋白质，如白蛋白结合，从而被输送到全身。许多多环芳烃通过结合芳烃受体或甘氨酸N-甲基转移酶蛋白，诱导细胞色素P450酶的表达，尤其是CYP1A1、CYP1A2和CYP1B1。这些酶将多环芳烃代谢成其有毒的中间产物。多环芳烃的反应性代谢物（环氧化物中间体、二氢二醇、酚、醌及其各种组合）与DNA和其他细胞大分子共价结合，启动突变和致癌作用。苯并(a)芘的主要致癌代谢物是反式-9,10-环氧-7,8-二氢二醇。

The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. The main carcinogenic metabolite of benzo(a)pyrene is the diol-epoxide trans-9,10-epoxy-7,8-dihydrodiol. (L10, L23, A27, A32)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

致癌性证据

分类：对人类致癌。分类依据：根据美国环保署（EPA）的致癌风险评估指南，苯并[a]芘在动物和人类中基于强烈且一致的证据被归类为“对人类致癌”。

CLASSIFICATION: Carcinogenic to humans. BASIS FOR CLASSIFICATION: Under EPA's Guidelines for Carcinogen Risk Assessment, benzo[a]pyrene is "carcinogenic to humans" based on strong and consistent evidence in animals and humans.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

致癌性证据

A2; 怀疑的人类致癌物。

A2; Suspected human carcinogen.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

致癌性证据

芘在实验动物中具有充分的致癌性证据...芘对人类具有致癌性（第1组）。

There is sufficient evidence for the carcinogenicity of benzo[a]pyrene in experimental animals...Benzo[a]pyrene is carcinogenic to humans (Group 1).

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

... 容易从肠道吸收，并倾向于主要定位于体内脂肪和脂肪组织，如乳腺。在大鼠单次静脉注射后，苯并(a)芘从血液和肝脏中消失得非常快，血液中的半衰期小于5分钟，肝脏中的半衰期为10分钟。在...血液和肝脏中...最初的快速消除阶段之后是较慢的消失阶段，持续6小时或更长时间... 血液中的苯并(a)芘与肝脏中的苯并(a)芘之间迅速建立平衡，并且...该化合物在血液中的快速消失是由于...代谢和组织分布。

... Readily absorbed from the intestinal tract and tend to localize primarily in body fat and fatty tissues such as breast. Disappearance of Benzo(a)Pyrene from blood and liver of rats following single IV injection is very rapid, having a half-life in blood of less than 5 min and a half-life in liver of 10 min. In ... blood and liver ... initial rapid elimination phase is followed by slower disappearance phase, lasting 6 hr or more ... A rapid equilibrium is established between BaP in blood and that in liver and ... the cmpd fast disappearance from blood is due to ... metabolism and distribution in tissues.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

BaP 在小鼠和大鼠中穿过胎盘... .

BaP crosses the placenta in mice & rats ... .

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在给予大鼠静脉注射(14)C-苯并[a]芘7分钟内，(14)C代谢物被分泌到胆汁中。用这种致癌物预处理动物...增强了(14)C的胆汁分泌。

(14)C metabolites were secreted into bile of rats within 7 min of iv dose of (14)C-benzo[a]pyrene. Pretreatment of animals with this carcinogen ... enhanced biliary secretion of (14)C.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

通过胆管插管的雄性大鼠接受了静脉注射放射性标记的苯并[a]芘（BaP），它与极低密度、低密度或高密度脂蛋白以等摩尔量非共价结合。与大鼠脂蛋白结合的BaP的累积胆汁排泄量分别为极低密度脂蛋白39.6%，低密度脂蛋白24.6%，高密度脂蛋白21.2%。与大鼠或人脂蛋白结合的BaP的排泄值相当。随着BaP羟基化程度的增加，排泄量增加。在Aroclor诱导的大鼠中，与极低密度、低密度或高密度脂蛋白结合的BaP的排泄量并不比对照组高。因此，在对照组或诱导动物中，注射的BaP的60-80%和注射的BaP代谢物的50-60%并没有立即排泄。因此，BaP可能代表一个缓慢排泄的致癌物池。

Male rats cannulated in the bile duct received iv injections of radiolabeled benzo[a]pyrene (BaP) noncovalently bound to the very-low-density, low-density, or high-density lipoproteins in equimolar amounts. Cumulative biliary excretions of BaP complexed with rat lipoproteins were 39.6, 24.6, and 21.2% for very-low density, low-density, and high-density lipoprotein, respectively. Values for excretion of BaP complexed with rat or human lipoproteins were comparable. Excretion increased as the degree of BaP hydroxylation increased. The excretion of BaP bound to very-low-density, low-density, or high-density lipoproteins in Aroclor-induced rats was not greater than the control. Hence, 60-80% of injected BaP and 50-60% of injected BaP metabolites were not excreted immediately in control or induced animals. Thus BaP may represent a carcinogen pool that is slowly excreted.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

TSCA：

Yes
危险等级：

6.1
危险品标志：

F,T
安全说明：

S26,S45,S53,S60,S61,S62
危险类别码：

R67,R38,R45,R50/53,R11,R65
WGK Germany：

3
海关编码：

2902909090
危险品运输编号：

2811
危险类别：

6.1
RTECS号：

DJ3675000
包装等级：

III
储存条件：

储存于阴凉、通风的库房。远离火种、热源，应与氧化剂、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。严格遵守极毒物品“五双”管理制度。

化学品中文名称：	苯并(a)芘；3，4-苯并芘
化学品英文名称：	Benzo(a)pyrene；3，4-Benzypyrene
中文俗名或商品名：
Synonyms：
CAS No.：	50-32-8
分子式：	C ₂₀ H ₁₂
分子量：	252.30

危险性类别：
侵入途径：	吸入食入经皮吸收
健康危害：	对眼睛、皮肤有刺激作用。是致癌物、致畸原及诱变剂。
环境危害：
燃爆危险：	本品可燃，高毒，为强烈致癌物，具刺激性。

皮肤接触：	脱去污染的衣着，用肥皂水及清水彻底冲洗。
眼睛接触：	立即翻开上下眼睑，用流动清水冲洗15分钟。就医。
吸入：	脱离污染环境，用水漱洗鼻咽部的粉尘。就医。
食入：	误服者充分漱口、饮水，催吐。就医。

危险特性：	遇明火、高热可燃。’受高热分解放出有毒的气体。
有害燃烧产物：	一氧化碳、二氧化碳、成分未知的黑色烟雾。
灭火方法及灭火剂：	二氧化碳、干粉、1211灭火剂、砂土。用水可引起沸溅。
消防员的个体防护：	消防人员须戴好防毒面具，在安全距离以外，在上风向灭火。
禁止使用的灭火剂：
闪点(℃)：	无资料
自燃温度(℃)：	引燃温度(℃)：无资料
爆炸下限[%(V/V)]：	无资料
爆炸上限[%(V/V)]：	无资料
最小点火能(mJ)：
爆燃点：
爆速：
最大燃爆压力(MPa)：
建规火险分级：

最高容许浓度：	中国 MAC：未制订标准前苏联MAC：0．00015mg／m3美国TLV—TWA：未制
监测方法：
工程控制：	密闭操作。提供良好的自然通风条件。
呼吸系统防护：	一般不需特殊防护，但建议特殊情况下，佩带自给式呼吸器。
眼睛防护：	戴安全防护眼镜。
身体防护：	穿聚乙烯薄膜防毒服。穿连衣式胶布防毒衣。
手防护：	必要时戴防化学品手套。戴橡胶手套。
其他防护：	工作后，淋浴更衣。避免长期反复接触。谨防其致癌性。

苯并[a]芘 | 50-32-8

物质功能分类

分子结构分类

物化性质

计算性质

ADMET

安全信息

SDS

制备方法与用途

上下游信息

反应信息

文献信息

表征谱图

同类化合物

相关功能分类

相关结构分类

热门分子

外观与性状：	无色至淡黄色、针状、晶体(纯品)。
pH：
熔点(℃)：	179
沸点(℃)：	495
相对密度(水=1)：	1．35
相对蒸气密度(空气=1)：
饱和蒸气压(kPa)：
燃烧热(kJ/mol)：
临界温度(℃)：
临界压力(MPa)：
辛醇/水分配系数的对数值：
闪点(℃)：	无资料
引燃温度(℃)：	引燃温度(℃)：无资料
爆炸上限%(V/V)：	无资料
爆炸下限%(V/V)：	无资料
分子式：	C ₂₀ H ₁₂
分子量：	252.30
蒸发速率：
粘性：
溶解性：	不溶于水，微溶于乙醇、甲醇，溶于苯、甲苯、二甲苯、氯仿、乙醚、丙酮等。
主要用途：	本品在工业上无生产和使用价值，一般只作为生产过程中形成的副产物随废气排放。

稳定性：	在常温常压下稳定
禁配物：	强氧化剂。
避免接触的条件：
聚合危害：	不能出现
分解产物：	一氧化碳、二氧化碳、成分未知的黑色烟雾。

急性毒性：	是多环芳烃中毒性最大的一种强烈致癌物。 LD50：小鼠腹腔：(MLD)500mg／kg；大鼠皮下：LD50：50mg／kg LC50：
急性中毒：
慢性中毒：
亚急性和慢性毒性：
刺激性：
致敏性：
致突变性：
致畸性：
致癌性：

生态毒理毒性：
生物降解性：
非生物降解性：
生物富集或生物积累性：

废弃物性质：
废弃处置方法：	根据国家和地方有关法规的要求处置。或与厂商或制造商联系，确定处置方法。
废弃注意事项：

危险货物编号：
UN编号：
包装标志：
包装类别：
包装方法：
运输注意事项：	储存于阴凉、干燥、通风良好的库房。远离火种、热源。保持容器密封。应与氧化剂分开存放。轻装轻卸。铁路运输时应严格按照铁道部《危险货物运输规则》中的危险货物配装表进行配装。起运时包装要完整，装载应稳妥。运输过程中要确保容器不泄漏、不倒塌、不坠落、不损坏。严禁与氧化剂、食用化学品等混装混运。运输途中应防曝晒、雨淋，防高温。运输车船必须彻底清洗、消毒，否则不得装运其它物品。
RETCS号：
IMDG规则页码：

国内化学品安全管理法规：	化学危险物品安全管理条例 (1987年2月17日国务院发布)，化学危险物品安全管理条例实施细则 (化劳发[1992] 677号)，工作场所安全使用化学品规定 ([1996]劳部发423号)等法规，针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定。
国际化学品安全管理法规：

参考文献：	1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989
填表时间：	年月日
填表部门：
数据审核单位：
修改说明：
其他信息：	4
MSDS修改日期：	年月日

中文名称	英文名称	CAS号	化学式	分子量
芘	pyrene	129-00-0	C₁₆H₁₀	202.255
萘	naphthalene	91-20-3	C₁₀H₈	128.174

中文名称	英文名称	CAS号	化学式	分子量
二苯并[a,h]蒽	dibenzo[a,h]anthracene	53-70-3	C₂₂H₁₄	278.353
3-甲基屈	3-methylchrysene	3351-31-3	C₁₉H₁₄	242.32
9-羟基苯并(a)芘	9-Hydroxybenzo[a]pyrene	17573-21-6	C₂₀H₁₂O	268.315