1-氰基环丁烷羧酸甲酯 | 58920-79-9

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1-氰基环丁烷羧酸甲酯
• 英文名称: methyl 1-cyanocyclobutanecarboxylate
• 英文别名: 1-Cyan-1-methoxycarbonyl-cyclobutan；1-cyano-cyclobutanecarboxylic acid methyl ester；1-cyano-cyclobutyl-carboxylic acid methyl ester；methyl 1-cyanocyclobutane-1-carboxylate
• CAS: 58920-79-9
• 化学式: C₇H₉NO₂
• mdl: MFCD10758063
• 分子量: 139.154
• InChiKey: WCTZTNWBOZFXTE-UHFFFAOYSA-N

物化性质

• 沸点：
  225.7±23.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2926909090
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  室温且干燥

反应信息

• 作为反应物：
  描述：

  1-氰基环丁烷羧酸甲酯 在 硼烷四氢呋喃络合物 、 potassium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 乙腈 为溶剂， 反应 136.0h， 生成 6-carboxymethyl-3-{{[1-(N,N-dicarboxymethyl)-2-aminomethyl]-cyclobut-1-yl}methyl}-3,6-diazaoctanedioic acid
  参考文献：
  名称：

  Ligand and metal complex

  摘要：

  提供了一种Formula (I)的配体： 其中A4代表氢原子、硝基、氨基、硫氰基或—Z—Y，其中Z是二价连接基团，Y是源自生物相容分子的基团，但当X为亚甲基时，A4不能是氢原子或硝基。还提供了具有该配体的金属配合物，可用作血池造影剂或靶向造影剂。

  公开号：

  US20110065905A1
• 作为产物：
  描述：

  1,3-二溴丙烷 、 氰乙酸甲酯 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以62.85%的产率得到1-氰基环丁烷羧酸甲酯
  参考文献：
  名称：

  Ligand and metal complex

  摘要：

  提供了一种Formula (I)的配体： 其中A4代表氢原子、硝基、氨基、硫氰基或—Z—Y，其中Z是二价连接基团，Y是源自生物相容分子的基团，但当X为亚甲基时，A4不能是氢原子或硝基。还提供了具有该配体的金属配合物，可用作血池造影剂或靶向造影剂。

  公开号：

  US20110065905A1
• 作为试剂：
  描述：

  氰乙酸甲酯 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 1,3-二溴丙烷 、 、 、 、 在 氮 、 氯仿 、 1-氰基环丁烷羧酸甲酯 、 SiO2 、 acetone hexane 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.17h， 以yielding 8.74 g (62.81%)的产率得到1-氰基环丁烷羧酸甲酯
  参考文献：
  名称：

  Cycloalkyl triamine pentacarboxylate as ligands for paramagnetic metal complexes

  摘要：

  提供了一种环状烷基三胺五羧酸化合物，它与金属离子配位形成高稳定性金属配合物在血清中。本发明的金属配合物可用作磁共振成像（MRI）的对比剂。

  公开号：

  US08877163B2

文献信息

• Efficient Decarboxylative/Defluorinative Alkylation for the Synthesis of <scp> <i>gem</i> ‐Difluoroalkenes </scp> through an <scp> S _N 2 </scp> ’‐Type Route
  作者：Wei‐Long Xing、Jia‐Xin Wang、Ming‐Chen Fu、Yao Fu

  DOI：10.1002/cjoc.202100709

  日期：2022.2

  An efficient decarboxylative/defluorinative alkylation for synthesizing gem-difluoroalkenes is described, providing a general method for installation of the challenging alkyl fragments containing α-electron-withdrawing groups into α-trifluoromethyl alkenes. Mechanistic studies suggest that this process involves an SN2′-type synthetic route in the absence of transition-metal catalysts or photocatalysis

  描述了一种用于合成偕二氟烯烃的有效脱羧/脱氟烷基化反应，为将含有 α-吸电子基团的具有挑战性的烷基片段安装到 α-三氟甲基烯烃中提供了一种通用方法。机理研究表明，该过程涉及在没有过渡金属催化剂或光催化的情况下的 S N 2' 型合成路线。此外，该协议可以很容易地扩大规模，并成功应用于生物活性分子的修饰，从而补充了获得结构通用的gem-二氟烯烃的方法。
• 含双并环类衍生物、其制备方法和应用
  申请人：上海翰森生物医药科技有限公司

  公开号：CN116444493A

  公开（公告）日：2023-07-18

  本发明涉及含双并环类衍生物、其制备方法和应用。特别地，本发明涉及通式(I)所示的化合物、其制备方法及含有该化合物的药物组合物，及其作为生物调节剂在制备治疗自身免疫疾病、慢性炎性疾病、急性炎症性疾病、自身炎性疾病、动脉粥样硬化、糖尿病、纤维变性疾病、代谢疾病、癌症、肿瘤、白血病和淋巴瘤的药物中的应用，其中通式(I)中的各取代基与说明书中的定义相同。
• Synthesis and Physicochemical Characterization of Carbon Backbone Modified [Gd(TTDA)(H₂O)]²⁻ Derivatives
  作者：Ya-Hui Chang、Chiao-Yun Chen、Gyan Singh、Hsing-Yin Chen、Gin-Chung Liu、Yih-Gang Goan、Silvio Aime、Yun-Ming Wang

  DOI：10.1021/ic101799c

  日期：2011.2.21

  The present study was designed to exploit optimum lipophilicity and high water-exchange rate (k(ex)) on low molecular weight Gd(III) complexs to generate high bound relaxivity (r(1)(b)), upon binding to the lipophilic site of human serum albumin (HSA). Two new carbon backbone modified TTDA (3,6,10-tri(carboxymethyl)-3,6,10-triazadodecanedioic acid) derivatives, CB-TTDA and Bz-CB-TTDA, were synthesized. The complexes [Gd(CB-TTDA)(H2O)](2-) and [Gd(Bz-CB-TTDA)(H2O)](2-) both display high stability constant (log K-GdL = 20.28 and 20.09, respectively). Furthermore, CB-TTDA (log K-(Gd/Zn) = 4.22) and Bz-CB-TTDA (log K-(Gd/Zn) = 4.12) exhibit superior selectivity of Gd(III) against Zn(II) than those of TTDA (log K-(Gd/Zn) = 2.93), EPTPA-bz-NO2 (log K-(Gd/Zn) = 3.19), and DTPA (log K-(Gd/Zn) = 3.76). However, the stability constant values of [Gd(CB-TTDA)(H2O)](2-) and [Gd(Bz-CB-TTDA)(H2O)](2-) are lower than that of MS-325. The parameters that affect proton relaxivity have been determined in a combined variable temperature O-17 NMR and NMRD study. The water exchange rates are comparable for the two complexes, 232 x 10(6) s(-1) for [Gd(CB-TTDA)(H2O)](2-) and 271 x 10(6) s(-1) for [Gd(Bz-CB-TTDA)(H2O)](2-). They are higher than those of [Gd(TTDA)(H2O)](2-) (146 x 10(6) s(-1)), [Gd(DTPA)(H2O)](2-) (4.1 x 10(6) s(-1)), and MS-325 (6.1 x 10(6) s(-1)). Elevated stability and water exchange rate indicate that the presence of cyclobutyl on the carbon backbone imparts rigidity and steric constraint to [Gd(CB-TTDA)(H2O)](2-) and [Gd(Bz-CB-TTDA)(H2O)](2-). In addition, the major objective for selecting the cyclobutyl is to tune the lipophilicity of [Gd(Bz-CB-TTDA)(H2O)](2-). The binding affinity of [Gd(Bz-CB-TTDA)(H2O)](2-) to HSA was evaluated by ultrafiltration study across a membrane with a 30 kDa MW cutoff, and the first three stepwise binding constants were determined by fitting the data to a stoichiometric model. The binding association constants (K-A) for [Gd(CB-TTDA)(H2O)](2-) and [Gd(Bz-CB-TTDA)(H2O)](2-) are 1.1 x 10(2) and 1.5 x 10(3), respectively. Although the K-A value for [Gd(Bz-CB-TTDA)(H2O)](2-) is lower than that of MS-325 (K-A = 3.0 x 10(4)), the r(1)(b) value, r(1)(b) = 66.7 mM(-1) s(-1) for [Gd(Bz-CB-TTDA)(H2O)](2-), is significantly higher than that of MS-325 (r(1)(b) = 47.0 mM(-1) s(-1)). As measured by the Zn(II) transmetalation process, the kinetic stabilities of [Gd(CB-TTDA)(H2O)](2-), [Gd(Bz-CB-TTDA)(H2O)](2-), and [Gd(DTPA)(H2O)](2-) are similar and are significantly higher than that of [Gd(DTPA-BMA)(H2O)](2-) High thermodynamic and kinetic stability and optimized lipophilicity of [Gd(CB-TTDA)(H2O)](2-) make it a favorable blood pool contrast agent for MRI.
• Preparation and Structure ofβ-Peptides Consisting of Geminally Disubstitutedβ2,2- andβ3,3-Amino Acids: A Turn Motif forβ-Peptides
  作者：Dieter Seebach、Stefan Abele、Thierry Sifferlen、Martin Hänggi、Sibylle Gruner、Paul Seiler

  DOI：10.1002/(sici)1522-2675(19981216)81:12<2218::aid-hlca2218>3.0.co;2-0

  日期：1998.12.16

  We report on the synthesis of new and previously described beta-peptides (1-6), consisting of up to twelve beta(2,2-) or beta(3,3)-geminally disubstituted beta-amino acids which do not fit into any of the secondary structural patterns of beta-peptides, hitherto disclosed. The required 2,2- and 3,3-dimethyl derivatives of 3-aminopropanoic acid are readily obtained from 3-methylbut-2-enoic acid and ammonia (Scheme 1) and from Boc-protected methyl 3-aminopropanoate by enolate methylation (Scheme 2). Protected (Boc for solution-, Fmoc for solid-phase syntheses) 1-(aminomethyl)cycloalkanecarboxylic-acid derivatives (with cyclopropane, cyclobutane, cyclopentane, and cyclohexane rings) are obtained from 1-cyanocycloalkanecarboxylates and the corresponding dihaloalkanes (Scheme 3). Fully C-13- and N-15-labeled 3-amino-2,2-dimethylpropanoic-acid derivatives were prepared from the corresponding labeled precursors (see asterixed formula numbers and Scheme 4). Coupling of these amino acids was achieved by methods which we had previously employed for other beta-peptide syntheses ( intermediates 18 - 23). Crystal structures of Boc-protected geminally disubstituted amine acids (16a-d) and of the corresponding tripeptide (23a), as well as NMR and IR spectra of an isotopically labeled beta-hexapeptide (2a*) are presented (Figs. 1-4) and discussed. The tripeptide structure contains a ten-membered H-bonded ring which is proposed to be a turn-forming motif for beta-peptides (Fig. 2).
• Oediger,H.; Moeller,F., Justus Liebigs Annalen der Chemie, 1976, p. 348 - 351
  作者：Oediger,H.、Moeller,F.

  DOI：——

  日期：——