Thiocarvacrol | 3695-37-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Thiocarvacrol
• 英文别名: 2-mercapto-p-cymene；2-Mercapto-p-cymol；2-Methyl-5-isopropyl-phenylmercaptan；2-Sulfhydryl-1-methyl-4-isopropyl-benzol；5-isopropyl-2-methylbenzenethiol；Carvacrylmercaptan；2-Methyl-5-(propan-2-YL)benzene-1-thiol；2-methyl-5-propan-2-ylbenzenethiol
• CAS: 3695-37-2
• 化学式: C₁₀H₁₄S
• mdl: MFCD18451846
• 分子量: 166.287
• InChiKey: LPAXQAHKKBQAEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Thiocarvacrol 在 碘 作用下， 生成 bis-(5-isopropyl-2-methyl-phenyl)-disulfide
  参考文献：
  名称：

  Flesch, Chemische Berichte, 1873, vol. 6, p. 478

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 、 锌 作用下， 生成 Thiocarvacrol
  参考文献：
  名称：

  METHYL ISOPROPYL THIOINDIGOID DYES FROM PARACYMENE. I. DYES FROM AMINOCYMENE¹

  摘要：

  DOI：

  10.1021/ja01368a064

文献信息

• Tobramycin Variants with Enhanced Ribosome-Targeting Activity
  作者：Marina Y. Fosso、Hongkun Zhu、Keith D. Green、Sylvie Garneau-Tsodikova、Kurt Fredrick

  DOI：10.1002/cbic.201500256

  日期：2015.7.27

  On the path against pathogens: The antibacterial, anti‐resistance, and ribosome‐targeting activities of 37 tobramycin derivatives were assessed. Thirteen of these compounds exhibited enhanced antibacterial properties over the parent compound with similar, or even enhanced, ribosome‐targeting activity, thereby providing insights for the design of antibiotics against aminoglycoside‐resistant strains

  在对抗病原体的道路上：评估了37种妥布霉素衍生物的抗菌，抗药性和核糖体靶向活性。这些化合物中的十三种具有比母体化合物更高的抗菌性能，具有相似甚至增强的核糖体靶向活性，从而为针对氨基糖苷抗性菌株的抗生素设计提供了见识。
• PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH CYCLIC AMINO GROUP
  申请人：NAKAZATO Atsuro

  公开号：US20110130364A1

  公开（公告）日：2011-06-02

  An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. This problem can be solved with a pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by formula [I] below which has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  本发明的目的是提供一种CRF受体拮抗剂，该拮抗剂作为治疗或预防CRF参与的疾病的药物，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃病、药物依赖、癫痫、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、皮炎、精神分裂症等方面有效。这个问题可以通过一种代表式[I]下的带有环状氨基基团的吡咯吡咪啉或吡咯吡啶衍生物来解决，该衍生物对CRF受体具有高亲和力，并对CRF参与的疾病有效。
• 1,3-dioxol-2-one derivatives, process for production thereof, and use thereof as substrate for measurement of arylesterase activity
  申请人：KANEBO, LTD.

  公开号：EP0233342A1

  公开（公告）日：1987-08-26

  A l,3-dioxol-2-one derivative represented by the following formula (I) wherein R¹ represents a hydrogen atom or an alkyl group having l to 4 carbon atoms, R², R³, R⁴, R⁵ and R⁶ re­present independently a hydrogen atom, a halogen atom, an alkyl group having l to 4 carbon atoms, an alkoxy group having l to 4 carbon atoms, a nitro group, a carboxyl group, salts of the carboxyl group, a sulfo group and salts of the sulfo group, and a process for producing the l,3-dioxol-2-one derivative. The compound is useful for measuring the activity of arylesterase.

  下式(I)代表的 l,3-二氧戊环-2-酮衍生物 其中 R¹ 代表氢原子或具有 l 至 4 个碳原子的烷基，R²、R³、R⁴、R⁵ 和 R⁶ 独立地代表氢原子、卤素原子、具有 l 至 4 个碳原子的烷基、具有 l 至 4 个碳原子的烷氧基、硝基、羧基、羧基的盐、磺基和磺基的盐，以及生产 l,3-二氧戊环-2-酮衍生物的工艺。该化合物可用于测量芳基酯酶的活性。
• Accelerators for increasing the rate of formation of free radicals and reactive oxygen species
  申请人：Cavalier Discovery

  公开号：US20030082101A1

  公开（公告）日：2003-05-01

  The formation of free radicals is enhanced with photodynamic agents, sonodynamic agents, and systems and therapies utilizing ultrasound by subjecting the agent to light waves or sound waves in the presence of a metal, a reductant, or a chelate, or mixtures thereof.

  光动力药剂、声动力药剂以及利用超声波的系统和疗法，在有金属、还原剂或螯合物或它们的混合物存在的情况下，使药剂受到光波或声波的作用，可促进自由基的形成。
• FR1507899
  申请人：——

  公开号：——

  公开（公告）日：——