rehmaglutin B | 103744-83-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: rehmaglutin B
• 英文别名: (1S,4S,5R,6S,7R,9S,11S)-5-chloro-2,10-dioxatricyclo[5.3.1.04,11]undecane-4,6,9-triol
• CAS: 103744-83-8
• 化学式: C₉H₁₃ClO₅
• 分子量: 236.652
• InChiKey: IRXIOTLCTXBESO-ZKXBHBSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  rehmaglutin B 在 吡啶 、 甲醇 作用下， 反应 7.0h， 生成 (1S,2R,2aS,2a1S,4aS,7aR)-2-chloro-6-((1,1,3,3-tetraisopropyl-3-methoxydisiloxaneyl)oxy)hexahydro-2H-4,5-dioxacyclopenta[cd]indene-1,2a(3H)-diol
  参考文献：
  名称：

  Absolute stereostructures of rehmaglutins A, B, and D three new iridoids isolated from Chinese Rehmanniae Radix.

  摘要：

  从生地黄中分离出了四种新的虹苷类化合物，即生地黄苷 A、B、C 和 D。根据化学和物理化学证据，包括苯甲酸手性法的应用，阐明了地黄苷 A（2__∼）、B（3__∼）和 D（4__∼）的绝对立体结构。

  DOI：

  10.1248/cpb.34.1399
• 作为产物：
  描述：

  梓醇 在 盐酸 、 甲醇 作用下， 反应 34.0h， 生成 rehmaglutin B
  参考文献：
  名称：

  Chemical Studies on Crude Drug Processing. VIII. On the Constituents of Rehmanniae Radix. (2): Absolute Stereostructures of Rehmaglutin C and Glutinoside Isolated from Chinese Rehmanniae Radix, the Dried Root of Rehmannia glutinosa Libosch.

  摘要：

  本文全面介绍了一种鸢尾内酯--地黄苷 C 和一种氯化三环鸢尾苷--谷苷的结构阐释。Rehmaglutin C（10）和 glutinoside（11）是从中国地黄中分离出来的。10 和 11 的绝对立体结构是根据化学和物理化学证据确定的，其中包括烯丙基苯甲酰基衍生物的激发子手性方法。

  DOI：

  10.1248/cpb.43.1096

文献信息

• Chemical Studies on Crude Drug Processing. VII. On the Constituents of Rehmanniae Radix. (1): Absolute Stereostructures of Rehmaglutins A, B, and D Isolated from Chinese Rehmanniae Radix,the Dried Root of Rehmannia glutinosa Libosch.
  作者：Isao KITAGAWA、Youichi FUKUDA、Toshio TANIYAMA、Masayuki YOSHIKAWA

  DOI：10.1248/cpb.39.1171

  日期：——

  An iridoid alcohol, rehmaglutin A, and two chlorinated iridoids, rehmaglutins B and D, were isolated from the less polar fraction of Chinese Rehmanniae Radix [the dried root of Rehmannia glutinosa LIBOSCH. (Kan-jio in Japanese)], together with rehmaglutin C, rehmaionoside C, jio-cerebroside, and acteoside. The absolute configurations of rehmaglutins A, B, and D were established on the basis of chemical and spectral evidence which included the chemical derivations of rehmaglutins from the known iridoid glycoside catalpol and the application of the bezoate chirality method.

  从地黄（地黄的干燥根）的极性较低的部分中分离出了一种鸢尾醇--地黄甙 A 和两种氯化鸢尾甙--地黄甙 B 和 D，以及地黄甙 C、地黄甙 C、地黄脑苷脂和地黄甙。雷公藤苷 A、B 和 D 的绝对构型是根据化学和光谱证据确定的，其中包括从已知的鸢尾苷梓醇中化学衍生出的雷公藤苷，以及苯甲酸酯手性方法的应用。
• Five cyclopentanoid monoterpenes from Rehmannia glutinosa
  作者：Takashi Morota、Hiroaki Nishimura、Hiroshi Sasaki、Masao Chin (Chen Zhengxiong)、Kô Sugama、Takao Katsuhara、Hiroshi Mitsuhashi

  DOI：10.1016/s0031-9422(00)97989-5

  日期：1989.1

  Abstract Five new cyclopentanoid monoterpenes named jioglutins A, B, C, jioglutolide and jiofuran, along with other known compounds, have been isolated from the steamed roots of Rehmannia glutinosa var. hueichingensis and their structures elucidated on the basis of chemical and spectroscopic methods.

  摘要 从熟地黄的蒸根中分离到了五种新的环戊烷单萜类化合物，称为胶凝素 A、B、C、胶鲁内酯和 jiofuran，以及其他已知化合物。Huichingensis 及其结构在化学和光谱方法的基础上阐明。
• MOROTA, TAKASHI;NISHIMURA, HIROAKI;SASAKI, HIROSHI;CHIN, MASAO;SUGAMA, KO+, PHYTOCHEMISTRY, 28,(1989) N, C. 2385-2391
  作者：MOROTA, TAKASHI、NISHIMURA, HIROAKI、SASAKI, HIROSHI、CHIN, MASAO、SUGAMA, KO+

  DOI：——

  日期：——
• Chemical Studies on Crude Drug Processing. VIII. On the Constituents of Rehmanniae Radix. (2): Absolute Stereostructures of Rehmaglutin C and Glutinoside Isolated from Chinese Rehmanniae Radix, the Dried Root of Rehmannia glutinosa Libosch.
  作者：Isao KITAGAWA、Youichi FUKUDA、Toshio TANIYAMA、Masayuki YOSHIKAWA

  DOI：10.1248/cpb.43.1096

  日期：——

  A full account of the structure elucidation of an iridoid lactone, rehmaglutin C, and a chlorinated tricyclic iridoid glucoside, glutinoside, is presented. Rehmaglutin C (10) and glutinoside (11) were isolated from Chinese Rehmanniae Radix, the dried root of Rehmannia glutinosa LIBOSCH. from China, called Kan-jio in Japanese. The absolute stereostructures 10 and 11 have been determined on the basis of chemical and physicochemical evidence which included application of the exciton chirality method for the allylic benzoyl derivative.

  本文全面介绍了一种鸢尾内酯--地黄苷 C 和一种氯化三环鸢尾苷--谷苷的结构阐释。Rehmaglutin C（10）和 glutinoside（11）是从中国地黄中分离出来的。10 和 11 的绝对立体结构是根据化学和物理化学证据确定的，其中包括烯丙基苯甲酰基衍生物的激发子手性方法。
• Absolute stereostructures of rehmaglutins A, B, and D three new iridoids isolated from Chinese Rehmanniae Radix.
  作者：Isao Kitagawa、Youichi Fukuda、Toshio Taniyama、Masayuki Yoshikawa

  DOI：10.1248/cpb.34.1399

  日期：——

  Four new iridoids, rehmaglutins A, B, C, and D, were isolated from Chinese Rehmanniae Radix, the dried root of Rehmannia glutinosa Li__=b__=o__=s__=c__=h__=. [Kan-jio (in Japanese) from China]. The absolute stereostructures of rehmaglutins A (2__∼), B (3__∼), and D (4__∼) were elucidated on the basis of chemical and physicochemical evidence which included the application of the benzoate chirality method.

  从生地黄中分离出了四种新的虹苷类化合物，即生地黄苷 A、B、C 和 D。根据化学和物理化学证据，包括苯甲酸手性法的应用，阐明了地黄苷 A（2__∼）、B（3__∼）和 D（4__∼）的绝对立体结构。