galactosamine 1-phosphate | 41588-64-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: galactosamine 1-phosphate
• 英文别名: D-galactosamine-1-phosphate；D-Galactosamine 1-phosphate；[(3R,4R,5R,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl] dihydrogen phosphate
• CAS: 41588-64-1
• 化学式: C₆H₁₄NO₈P
• 分子量: 259.153
• InChiKey: YMJBYRVFGYXULK-GASJEMHNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  163
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  尿苷(5')二氢二磷酰(1)-alpha-D-葡萄糖 、 galactosamine 1-phosphate 在 Gal-1-P-uridyl transferase 作用下， 生成 尿苷二磷酸酯半乳糖胺
  参考文献：
  名称：

  En route to deoxygenated N-acetyllactosamine analogues employing uridyl and galactosyl transferases

  摘要：

  All monodeoxygenated galactoses were treated with galactokinase, and for the 2-, 3-, and 4-deoxy compounds, transformation into the corresponding galactopyranosyl phosphates could be observed. In case of the 2-deoxy derivative, further reaction via UDP-2-deoxy-D-lyxo-hexose (UDP-2-deoxygalactose), which was also obtained chemically, the multiple enzymatic system could be employed to prepare 2'-deoxy-N-acetyllactosamine. (C) 2009 Elsevier Ltd. Ail rights reserved.

  DOI：

  10.1016/j.carres.2009.05.015
• 作为产物：
  描述：

  Galactosamine 在 magnesium chloride hexahydrate 、 sodium azide 、 2(1H)-喹啉酮,1-丙基- 、 pyruvate kinase 、 磷烯醇丙酮酸 、 potassium chloride 、 5’-三磷酸腺苷 、 Cleland's reagent 、 bovine serum albumin 作用下， 以 三羟甲基氨基甲烷 为溶剂， 生成 galactosamine 1-phosphate
  参考文献：
  名称：

  En route to deoxygenated N-acetyllactosamine analogues employing uridyl and galactosyl transferases

  摘要：

  All monodeoxygenated galactoses were treated with galactokinase, and for the 2-, 3-, and 4-deoxy compounds, transformation into the corresponding galactopyranosyl phosphates could be observed. In case of the 2-deoxy derivative, further reaction via UDP-2-deoxy-D-lyxo-hexose (UDP-2-deoxygalactose), which was also obtained chemically, the multiple enzymatic system could be employed to prepare 2'-deoxy-N-acetyllactosamine. (C) 2009 Elsevier Ltd. Ail rights reserved.

  DOI：

  10.1016/j.carres.2009.05.015

文献信息

• En route to deoxygenated N-acetyllactosamine analogues employing uridyl and galactosyl transferases
  作者：Daniel Lazarevic、Harald Streicher、Joachim Thiem

  DOI：10.1016/j.carres.2009.05.015

  日期：2009.8

  All monodeoxygenated galactoses were treated with galactokinase, and for the 2-, 3-, and 4-deoxy compounds, transformation into the corresponding galactopyranosyl phosphates could be observed. In case of the 2-deoxy derivative, further reaction via UDP-2-deoxy-D-lyxo-hexose (UDP-2-deoxygalactose), which was also obtained chemically, the multiple enzymatic system could be employed to prepare 2'-deoxy-N-acetyllactosamine. (C) 2009 Elsevier Ltd. Ail rights reserved.