Alpha-D-葡糖醛酸-1-磷酸 | 13168-11-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: Alpha-D-葡糖醛酸-1-磷酸
• 中文别名: Α-D-葡糖醛酸-1-磷酸
• 英文名称: α-D-glucopyranuronic acid 1-phosphate
• 英文别名: α-glucuronic acid 1-phosphate；α-D-GlcA-1-P；ClcA-1-P；O¹-phosphono-α-D-glucopyranuronic acid；O¹-Phosphono-α-D-glucopyranuronsaeure；α-D-Glucuronsaeure-1-phosphat；1-phospho-alpha-D-glucuronic acid；(2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-phosphonooxyoxane-2-carboxylic acid
• CAS: 13168-11-1
• 化学式: C₆H₁₁O₁₀P
• 分子量: 274.121
• InChiKey: AIQDYKMWENWVQJ-QIUUJYRFSA-N

物化性质

• 沸点：
  685.1±65.0 °C(Predicted)
• 密度：
  2.05±0.1 g/cm3(Predicted)
• 溶解度：
  溶于甲醇；水
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  Alpha-D-葡糖醛酸-1-磷酸 在 甲酸 、 水 作用下， 生成 葡醛内酯
  参考文献：
  名称：

  Barker et al., Journal of the Chemical Society, 1958, p. 4128,4129

  摘要：

  DOI：
• 作为产物：
  描述：

  D-吡喃葡萄糖醛酸 在 recombinant Arabidopsis thaliana glucuronokinase; molecular weight around 42 kDa 、 5’-三磷酸腺苷 、 magnesium chloride 作用下， 以 aq. buffer 为溶剂， 以100%的产率得到Alpha-D-葡糖醛酸-1-磷酸
  参考文献：
  名称：

  Improved one-pot multienzyme (OPME) systems for synthesizing UDP-uronic acids and glucuronides

  摘要：

  高效的一锅多酶（OPME）系统已经建立起来，用于从简单单糖合成UDP-GlcA、UDP-GalA和葡萄糖醛酸酯。

  DOI：

  10.1039/c4cc10306h

文献信息

• CHEMOENZYMATIC SYNTHESIS OF HEPARIN AND HEPARAN SULFATE ANALOGS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20140235575A1

  公开（公告）日：2014-08-21

  The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.

  本发明提供了一种一锅多酶法，用于从简单糖起始材料制备UDP糖。该发明还提供了一种一锅多酶法，用于从简单糖起始材料制备寡糖。
• Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and "unnatural" UDP- and TDP-nucleotide sugars
  申请人：——

  公开号：US20030055235A1

  公开（公告）日：2003-03-20

  The present invention provides mutant nucleotidylyl-transferases, such as E p , having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.

  本发明提供了一种突变型核苷酸转移酶，如E p ，具有改变的底物特异性；其生产方法；以及利用这些核苷酸转移酶生产核苷酸糖的方法。本发明还提供了使用天然和/或修饰的Ep或其他核苷酸转移酶合成所需的核苷酸糖的方法；以及通过本发明方法合成的核苷酸糖。本发明进一步提供了新的糖基磷酸酯，及其制造方法。
• ACTIVE-SITE ENGINEERING OF NUCLEOTIDYLYLTRANSFERASES AND GENERAL ENZYMATIC METHODS FOR THE SYNTHESIS OF NATURAL AND "UNNATURAL" UDP- AND TDP-NUCLEOTIDE SUGARS
  申请人：THORSON Jon

  公开号：US20070178487A1

  公开（公告）日：2007-08-02

  The present invention provides mutant nucleotidylyl-transferases, such as E p , having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified E p or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.

  本发明提供了突变核苷酸转移酶，例如Ep，具有改变的底物特异性；其生产方法；以及利用这些核苷酸转移酶生产核苷酸糖的方法。本发明还提供了使用天然和/或改性的Epor或其他核苷酸转移酶合成所需核苷酸糖的方法；以及通过本方法合成的核苷酸糖。本发明还提供了新的糖基磷酸酯，以及制备它们的方法。
• Process for selective oxidation of primary alcohols
  申请人：Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNO

  公开号：US06518419B1

  公开（公告）日：2003-02-11

  Primary alcohols, especially in carbohydrates, can be selectively oxidized to aldehydes and carboxylic acids in a low-halogen process by using a peracid in the presence of a catalytic amount of a di-tertiary-alkyl nitroxyl (TEMPO) and a catalytic amount of halide. The halide is preferably bromide and the process can be carried out at nearly neutral to moderately alkaline pH (5-11). The peracid can be produced or regenerated by means of hydrogen peroxide or oxygen. The process is advantageous for producing uronic acids and for introducing aldehyde groups which are suitable for crosslinking and derivatization.

  主要醇类，特别是碳水化合物中的醇类，可以在低卤素过程中选择性地氧化为醛和羧酸，方法是在存在少量二叔丁基亚硝基（TEMPO）催化剂和卤化物催化剂的情况下使用过氧酸。卤化物最好是溴化物，该过程可以在近中性至中等碱性pH（5-11）下进行。过氧酸可以通过过氧化氢或氧气产生或再生。该过程有利于生产糖醛酸并引入适用于交联和衍生化的醛基团。
• METHOD AND APPARATUS FOR ANALYZING AMINO ACID, PEPTIDE, PROTEIN, SACCHARIDE OR LIPID
  申请人：Gl Sciences Incorporated

  公开号：EP1477800A1

  公开（公告）日：2004-11-17

  The present invention aims to easily and simply perform selective detection/identification, extraction, separation, and purification of a phosphorylated amino acid, phosphorylated peptide, or phosphorylated protein from a sample containing any one of them, comprising the steps of: retaining the phosphorylated amino acid, phosphorylated peptide, or phosphorylated protein in a pretreatment column by passing the sample containing the phosphorylated amino acid, phosphorylated peptide, or phosphorylated protein through a reversed phase HPLC column having a titanium dioxide column as the pretreatment column and retaining a non-phosphorylated amino acid, peptide, or protein in the reverse phase HPLC column; eluting the non-phosphorylated amino acid, peptide, or protein that is retained in the reversed phase HPLC column; eluting the phosphorylated amino acid, phosphorylated peptide, or phosphorylated protein retained in the pretreatment column with buffer; and detecting it.

  本发明旨在简单易行地从含有磷酸化氨基酸、磷酸化肽或磷酸化蛋白质的样品中选择性地检测/识别、提取、分离和纯化磷酸化氨基酸、磷酸化肽或磷酸化蛋白质，包括以下步骤：将含有磷酸化氨基酸、磷酸化肽或磷酸化蛋白质的样品通过以二氧化钛柱为预处理柱的反相高效液相色谱柱，将磷酸化氨基酸、磷酸化肽或磷酸化蛋白质保留在预处理柱中，并将非磷酸化氨基酸、肽或蛋白质保留在反相高效液相色谱柱中；洗脱保留在反相高效液相色谱柱中的非磷酸化氨基酸、肽或蛋白质；用缓冲液洗脱保留在预处理柱中的磷酸化氨基酸、磷酸化肽或磷酸化蛋白质；以及检测。