(7R,3'R)-lonijapospiroside A

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (7R,3'R)-lonijapospiroside A
• 英文别名: lonjaponspiroside A
• 化学式: C₂₇H₃₁NO₁₂
• 分子量: 561.543
• InChiKey: RTLOXEMMJLUKBN-FVCGQZEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.77
• 重原子数：
  40.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  190.31
• 氢给体数：
  5.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  (7R,3'R)-lonijapospiroside A 在 盐酸 作用下， 以 水 为溶剂， 反应 2.0h， 生成 葡萄糖
  参考文献：
  名称：

  金银花一种新的含氮环烯醚萜苷

  摘要：

  摘要 从金银花的花蕾中分离出一种新的含氮环烯醚萜苷，命名为 (7  R ,3' R) -lonijapospiroside A ( 1 )，以及十三种已知的环烯醚萜苷。这些化合物的结构是在光谱分析的基础上确定的。其中，化合物1-4是四种非对映异构体，它们的绝对构型是通过 NOE 光谱以及它们的实验和计算 ECD 光谱的比较准确确定的。通过测量它们对LPS 刺激的 RAW 264.7 巨噬细胞中NO、IL-6 和 TNF- α产生的抑制作用来评估所有分离物的抗炎活性。化合物14通过与IC抑制IL-6显示出抗炎活性50值的54.70  μ男，比得上阳性对照（氢化可的松，IC的50：62.6±1.7μM）。

  DOI：

  10.1080/14786419.2019.1705819

文献信息

• Secondary metabolites from the flower buds of Lonicera japonica and their in vitro anti-diabetic activities
  作者：Zhixiang Liu、Zhuoyang Cheng、Qingjun He、Bin Lin、Pinyi Gao、Lingzhi Li、Qingbo Liu、Shaojiang Song

  DOI：10.1016/j.fitote.2016.02.011

  日期：2016.4

  Four new compounds (1, 2, 7 and 8) and twenty known compounds were isolated from the flower buds of Lonicerajaponica. Their structures were determined by extensive NMR and HR-ESIMS spectroscopic data analyses. Among them, compounds 1 and 2 are a pair of diastereoisomers possessing a rare chemical structure, and their absolute configurations were determined by comparing their experimental and calculated ECD spectra. Furthermore, all the isolates were evaluated for their inhibitory effects on a-glucosidase and protein tyrosine phosphatase IB (PTP1B), especially 1 and 2, which displayed both significant inhibitions. In addition, the possible action mechanism of the active compounds was also explored by using molecular docking studies. (C) 2016 Elsevier B.V. All rights reserved.
• A new nitrogen-containing iridoid glycoside from <i>lonicera macranthoides</i>
  作者：Yu-Dan Mei、Hai-Bo Li、Ling-Xian Liu、Dan-feng Shi、Da-bo Pan、Xin-Sheng Yao、Yang Yu

  DOI：10.1080/14786419.2019.1705819

  日期：2021.10.18

  Abstract A new nitrogen-containing iridoid glycoside, named (7 R,3′R)-lonijapospiroside A (1), together with thirteen known iridoid glycosides, were isolated from the flower buds of Lonicera macranthoides. The structures of these compounds were established on the basis of spectroscopic analyses. Among them, compounds 1-4 are four diastereoisomers, and their absolute configurations were accurately established

  摘要 从金银花的花蕾中分离出一种新的含氮环烯醚萜苷，命名为 (7  R ,3' R) -lonijapospiroside A ( 1 )，以及十三种已知的环烯醚萜苷。这些化合物的结构是在光谱分析的基础上确定的。其中，化合物1-4是四种非对映异构体，它们的绝对构型是通过 NOE 光谱以及它们的实验和计算 ECD 光谱的比较准确确定的。通过测量它们对LPS 刺激的 RAW 264.7 巨噬细胞中NO、IL-6 和 TNF- α产生的抑制作用来评估所有分离物的抗炎活性。化合物14通过与IC抑制IL-6显示出抗炎活性50值的54.70  μ男，比得上阳性对照（氢化可的松，IC的50：62.6±1.7μM）。