Malonsaeure-bis-isopropylidenhydrazid | 3815-87-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Malonsaeure-bis-isopropylidenhydrazid
• 英文别名: N'~1~,N'~3~-di(propan-2-ylidene)propanedihydrazide；N,N'-bis(propan-2-ylideneamino)propanediamide
• CAS: 3815-87-0
• 化学式: C₉H₁₆N₄O₂
• mdl: MFCD00137183
• 分子量: 212.252
• InChiKey: KJMYPGUTMKXBQM-UHFFFAOYSA-N

物化性质

• 熔点：
  185 °C
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.555
• 拓扑面积：
  82.9
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  Malonsaeure-bis-isopropylidenhydrazid 在 sodium tetrahydroborate 作用下， 生成 Malonsaeure-di-(N'-isopropyl)-hydrazid
  参考文献：
  名称：

  Braeuniger; Moede, Pharmazie, 1969, vol. 24, # 12, p. 720 - 727

  摘要：

  DOI：
• 作为产物：
  描述：

  丙二酰肼 、 丙酮 反应 2.0h， 以98%的产率得到Malonsaeure-bis-isopropylidenhydrazid
  参考文献：
  名称：

  [EN] NANOSTRUCTURE-BETA-BLOCKER CONJUGATES
  [FR] CONJUGUÉS BÊTABLOQUANTS NANOSTRUCTURÉS

  摘要：

  提供了纳米结构-β受体阻滞剂共轭物。此外，还提供了合成纳米结构β受体阻滞剂共轭物的方法，以及它们在骨疾病治疗和预防中的应用，如骨质疏松症。

  公开号：

  WO2011019882A1

文献信息

• A Study of the Inhibitory Effect of Various Hydrazides on Monoamine Oxidase in vitro and in vivo
  作者：Jacob Szmuszkovicz、Margaret E. Greig

  DOI：10.1021/jm50018a004

  日期：1961.9
• Narang, K. K.; Singh, Meena Kumari, Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1987, vol. 17, p. 57 - 78
  作者：Narang, K. K.、Singh, Meena Kumari

  DOI：——

  日期：——
• Conversions of Coumarins Accompanied by Intermediate Opening and Recyclization of the Lactone Ring. 2. Study of the Interaction of Malonic Acid Hydrazide and Amide Derivatives with 3-Acyl(3-cyano, 3-ethoxycarbonyl)Coumarins
  作者：M. P. Nemeryuk、V. D. Dimitrova、O. S. Anisimova、A. L. Sedov、N. P. Solov'eva、V. F. Traven

  DOI：10.1007/s10593-005-0311-4

  日期：2005.10
• Synthesis of mesoionic[1,2,3]triazolo[5,1-d][1,2,5]triazepines
  作者：Elena A Savel'eva、Yury A Rozin、Mikhail I Kodess、Luc Van Meervelt、Wim Dehaen、Yury Yu Morzherin、Vasiliy A Bakulev

  DOI：10.1016/j.tet.2004.04.067

  日期：2004.6

  Intramolecular cyclization of 1-amino-3-phenacyl-4-carbohydrazido-1,2,3-triazolium-5-olates has been shown to take place via selective interaction of the carbonyl group with the terminal amino function of the hydrazido group to form a 1,2,5-triazepine ring. Minor products, resulting from the interaction of the a-nitrogen atom of the hydrazido group with the carbonyl function, having a N-aminopyridazine structure were also detected and isolated. A general method for the synthesis of novel mesoionic 2-amino-7-aryl-4-oxo-2,4,5,8-tetrahydro[1,2,3]triazolo[5,1-d][1,2,5]triazepin-9-ium-3-olates was developed. (C) 2004 Elsevier Ltd. All rights reserved.
• [EN] AQUEOUS POLYMER COMPOSITION<br/>[FR] COMPOSITION AQUEUSE DE POLYMÈRE
  申请人：COMMW SCIENT IND RES ORG

  公开号：WO2018112555A1

  公开（公告）日：2018-06-28

  The present invention relates to a storage stable crosslinkable aqueous polymer composition comprising: (a) an aqueous liquid; (b) a copolymer solubilised in the aqueous liquid by a fugitive non-gas acid, the copolymer comprising polymerised residues of: (i) ethylenically unsaturated monomer comprising a basic functional group that is protonated by the fugitive non-gas acid, the polymerised residues of that monomer being present in an amount of less than 25 mol%, relative to the total number of mols of polymerised monomer residues of the copolymer; (ii) ethylenically unsaturated monomer comprising a functional group for promoting crosslinking of the copolymer; and (iii) hydrophobic ethylenically unsaturated monomer; and (c) (i) a reversibly blocked crosslinking agent for promoting crosslinking of the copolymer, and (ii) a fugitive crosslinking inhibitor for inhibiting crosslinking of the copolymer by the reversibly blocked crosslinking agent.