8-chloro-4-hydroxy-1-oxo-1,2-dihydropyridazino[4,5-b]quinoline | 202808-16-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-chloro-4-hydroxy-1-oxo-1,2-dihydropyridazino[4,5-b]quinoline
• 英文别名: 8-Chloro-2,3-dihydropyridazino[4,5-b]quinoline-1,4-dione
• CAS: 202808-16-0
• 化学式: C₁₁H₆ClN₃O₂
• 分子量: 247.641
• InChiKey: ZFHPMXIDQAEWDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  四乙基氢氧化铵 、 8-chloro-4-hydroxy-1-oxo-1,2-dihydropyridazino[4,5-b]quinoline 以 水 为溶剂， 以83.5%的产率得到tetraethylammonium salt of 8-chloro-4-hydroxy-1-oxo-1,2-dihydropyridazino[4,5-b]quinoline, tetraethylammonium salt
  参考文献：
  名称：

  环状酰肼。2.取代的4-羟基-1-氧代-1,2-二氢吡a酮[4,5-b]喹啉5-氧化物的合成

  摘要：

  DOI：

  10.1007/bf02315189
• 作为产物：
  描述：

  5-氯-2-硝基苯甲醛 在 甲醇 、 sodium 、 一水合肼 、 溶剂黄146 、 三氯化磷 作用下， 以 氯仿 为溶剂， 反应 19.0h， 生成 8-chloro-4-hydroxy-1-oxo-1,2-dihydropyridazino[4,5-b]quinoline
  参考文献：
  名称：

  环状酰肼

  摘要：

  DOI：

  10.1007/bf02290617

文献信息

• PYRIDAZINO 4,5-B]-QUINOLINE 5-OXIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS GLYCINE ANTAGONISTS
  申请人：MERZ + CO. GmbH & Co.

  公开号：EP0931081B1

  公开（公告）日：2002-09-25
• METHODS OF TREATING OR AMELIORATING MIGRAINE
  申请人：Northwestern University

  公开号：EP3157943A1

  公开（公告）日：2017-04-26
• [EN] COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A CANNABINOID AGENT FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE<br/>[FR] COMPOSITIONS RENFERMANT UN INHIBITEUR SELECTIF DE LA CYCLOOXYGENASE-2 ET UN AGENT CANNABINOIDE SERVANT AU TRAITEMENT DE LESIONS DU SYSTEME NERVEUX CENTRAL
  申请人：PHARMACIA CORP

  公开号：WO2004105699A2

  公开（公告）日：2004-12-09

  The present invention provides compositions and methods for the treatment of central nervous system damage in a subject. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic condition or a central nervous system traumatic injury comprising the administration to a subject of a cannabinoid agent in combination with a cyclooxygenase-2 selective inhibitor.
• [EN] METHODS OF TREATING OR AMELIORATING MIGRAINE<br/>[FR] PROCÉDÉS DE TRAITEMENT OU DE SOULAGEMENT DE LA MIGRAINE
  申请人：UNIV NORTHWESTERN

  公开号：WO2015200322A1

  公开（公告）日：2015-12-30

  In certain embodiments, the invention relates to methods for treating migraine (e.g. episodic migraine, chronic migraine, retinal migraine, ophthalmoplegic migraine, acephalgic migraine, migrainous disorder, menstrual migraine, abdominal migraine, childhood periodic syndromes, or cluster headache) by administering a peptide NMDAR partial agonist. In certain embodiments, the invention also relates to methods for treating or ameliorating long-term post migraine sequelae in a patient by administering a peptide NMDAR partial agonist. In certain other embodiments, the invention relates to methods for treating, suppressing, or preventing cortical spreading depression or a disease or condition caused by cortical spreading depression in a patient in need thereof, comprising administering a peptide NMDAR partial agonist. For example, provided herein are methods of treating epilepsy, traumatic brain injury, and/or stroke.
• Cyclic hydrazides
  作者：E. Rozhkov、I. Piskunova、M. Gol'd、I. Kalvin'sh

  DOI：10.1007/bf02290617

  日期：1998.1